CYN 154806 is a potent and selective antagonist of somatostatin sst2 receptor.
CAT No: R0860
CAS No:183658-72-2
Synonyms/Alias:CYN 154806;183658-72-2;CYN-154806;(4R,7S,10S,13R,16S,19S)-19-[[(2S)-2-Acetamido-3-(4-nitrophenyl)propanoyl]amino]-10-(4-aminobutyl)-N-[(2R)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide;CYN154806;CYN 154806 trifluoroacetate;BDBM85671;Cyanamid 154806 trifluoroacetate;EX-A5981;HY-P1202;IHA65872;AKOS024456810;CYN 154806?;acetyl-4-nitrophenylalanyl-cyclo(cysteinyl-tyrosyl-tryptophyl-lysyl-threonyl-cysteinyl)-tyrosinamide;DA-72499;CAS_183658-72-2;CS-0028994;
CYN 154806 is a synthetic peptide compound recognized for its role as a selective antagonist of the growth hormone secretagogue receptor (GHS-R1a), also known as the ghrelin receptor. Structurally derived from peptide frameworks, it has become an important research tool for probing the physiological and biochemical pathways regulated by ghrelin signaling. Its ability to modulate receptor activity with high specificity enables detailed studies into the mechanisms of energy balance, appetite regulation, and neuroendocrine function. The compound's selective antagonism and well-characterized receptor interactions make it invaluable for dissecting complex signaling networks within both in vitro and in vivo research contexts.
Receptor Pharmacology: CYN 154806 is extensively utilized in receptor pharmacology studies to characterize the binding dynamics and functional consequences of GHS-R1a inhibition. By selectively blocking ghrelin receptor activation, it allows researchers to delineate the downstream signaling pathways and assess receptor-ligand interactions with precision. This application is particularly valuable in elucidating the molecular basis of receptor-mediated processes, providing insights that inform the development of novel modulators and enhancing our understanding of peptide-receptor pharmacodynamics.
Metabolic Regulation Research: The compound serves as a critical tool for investigating the role of ghrelin signaling in metabolic homeostasis. In cellular and animal models, CYN 154806 enables the targeted suppression of ghrelin-induced effects, facilitating studies on appetite control, energy expenditure, glucose metabolism, and lipid mobilization. Researchers employ it to dissect the contribution of GHS-R1a to metabolic disorders and to explore the physiological consequences of modulating this pathway, thereby advancing knowledge in endocrinology and metabolic disease research.
Neuroendocrine Function Studies: As a peptide antagonist, CYN 154806 is applied in the exploration of neuroendocrine regulatory mechanisms, particularly those involving the hypothalamic-pituitary axis. By inhibiting ghrelin receptor activity, it allows for the assessment of neuropeptide signaling in hormone secretion, stress response, and circadian rhythm regulation. Its use in these studies provides a controlled means to investigate the interplay between central and peripheral signals in neuroendocrine physiology.
Peptide Antagonist Validation: The compound is frequently employed as a reference antagonist in the validation of new peptide-based modulators of the GHS-R1a receptor. Its well-defined inhibitory profile enables comparative studies, assay calibration, and benchmarking of novel compounds. This application supports the development and optimization of next-generation peptide ligands, contributing to advancements in peptide drug discovery and receptor-targeted research.
Signal Transduction Analysis: CYN 154806 is instrumental in dissecting intracellular signaling cascades initiated by ghrelin receptor activation. By selectively blocking receptor function, it enables researchers to map downstream effector pathways, quantify second messenger responses, and identify key molecular intermediates. The compound's specificity enhances the accuracy of signal transduction studies, supporting the identification of novel therapeutic targets and deepening the mechanistic understanding of peptide hormone signaling.
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