- Home
- COVID-19
- Services
- Products
- Research Areas
- Company
- Resources
- Ordering
Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.
| CAT# | 10-101-256 |
| Explanation | FC 131 is an antagonist of CXCR4 with anti-HIV activity |
| Synonyms/Alias | Cyclo[2-Nal-Gly-D-Tyr-Arg-Arg] |
| Chemical Name | cyclo[3-(2-naphthalenyl)-L-alanylglycyl-D-tyrosyl-L-arginyl-L-arginyl] |
| M.F/Formula | C36H47N11O6 |
| M.W/Mr. | 729.8 |
| Sequence | One Letter Code: XGYRR (Modifications: Cyclic peptide, X = 2-Nal, Tyr-3 = D-Tyr] Three Letter Code: Nal-Gly-Tyr-Arg-Arg |
| Labeling Target | C-X-C chemokine receptor type 4 (CXCR4) |
| Application | CXCR4 antagonist (IC50 = 126 nM). Displays anti-HIV activity in assays using NL4-3 and IIIB strains (EC50 = 21 nM for both strains). |
| Appearance | Crystalline solid |
| Purity | ≥95% |
| Activity | Antagonist |
| Biological Activity | FC131 (cyclo (-D-Tyr-Arg-Arg-Nal-Gly-)) is a selective, cyclopentapeptide CXCR4 antagonist with IC50 of 126nM, exhibits anti-HIV activity in assays using NL4-3 and IIIB strains with EC50 of 21nM. |
| Target | CXCR |
| Source# | Synthetic | Long-term Storage Conditions | Soluble in 20% acetonitrile/water (2 mg/ml). | Shipping Condition | Shipped at room temperature | Short-term Storage Conditions | Dry, dark and at 0 - 4 °C | Solubility | -20 °C | InChI | InChI=1S/C36H47N11O6/c37-35(38)41-15-3-7-26-32(51)45-27(8-4-16-42-36(39)40)33(52)47-28(19-22-9-12-23-5-1-2-6-24(23)17-22)31(50)43-20-30(49)44-29(34(53)46-26)18-21-10-13-25(48)14-11-21/h1-2,5-6,9-14,17,26-29,48H,3-4,7-8,15-16,18-20H2,(H,43,50)(H,44,49 | InChI Key | MBXBICVKLVYNKD-XFTNXAEASA-N | Canonical SMILES | O=C(NCC(N[C@@H]1CC2=CC=C(O)C=C2)=O)[C@@H](NC([C@@H](NC([C@@H](NC1=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC3=CC(C=CC=C4)=C4C=C3 | Isomeric SMILES | C1C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC2=CC3=CC=CC=C3C=C2)CCCN=C(N)N)CCCN=C(N)N)CC4=CC=C(C=C4)O | BoilingPoint | N/A | ShelfLife | >2 years if stored properly | Melting Point | N/A |
| CAT# | Product Name | M.W | Molecular Formula | Inquiry |
|---|---|---|---|---|
| 10-101-320 | [Des-octanoyl]-Ghrelin (rat) | Inquiry | ||
| 10-101-154 | PMX 205 | Inquiry | ||
| 10-101-204 | TFLLR-NH2(TFA) | Inquiry | ||
| 10-101-33 | Thymopentin Acetate | Inquiry | ||
| 10-101-198 | Octreotide-phenylalanine-d8 di-Trifluoroacetic Acid Salt | Inquiry |
* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).
