FC131

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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CAT#10-101-256
ExplanationFC 131 is an antagonist of CXCR4 with anti-HIV activity
Synonyms/AliasCyclo[2-Nal-Gly-D-Tyr-Arg-Arg]
Chemical Namecyclo[3-(2-naphthalenyl)-L-alanylglycyl-D-tyrosyl-L-arginyl-L-arginyl]
M.F/FormulaC36H47N11O6
M.W/Mr.729.8
SequenceOne Letter Code: XGYRR (Modifications: Cyclic peptide, X = 2-Nal, Tyr-3 = D-Tyr] 
Three Letter Code: Nal-Gly-Tyr-Arg-Arg
Labeling TargetC-X-C chemokine receptor type 4 (CXCR4)
ApplicationCXCR4 antagonist (IC50 = 126 nM). Displays anti-HIV activity in assays using NL4-3 and IIIB strains (EC50 = 21 nM for both strains).
AppearanceCrystalline solid
Purity≥95%
ActivityAntagonist
Biological ActivityFC131 (cyclo (-D-Tyr-Arg-Arg-Nal-Gly-)) is a selective, cyclopentapeptide CXCR4 antagonist with IC50 of 126nM, exhibits anti-HIV activity in assays using NL4-3 and IIIB strains with EC50 of 21nM.
TargetCXCR
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