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FC131

FC 131 is an antagonist of CXCR4 with anti-HIV activity

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CAT#	10-101-256
CAS	606968-52-9
Synonyms/Alias	Cyclo[2-Nal-Gly-D-Tyr-Arg-Arg]
Chemical Name	cyclo[3-(2-naphthalenyl)-L-alanylglycyl-D-tyrosyl-L-arginyl-L-arginyl]
M.F/Formula	C36H47N11O6
M.W/Mr.	729.8
Sequence	One Letter Code: XGYRR (Modifications: Cyclic peptide, X = 2-Nal, Tyr-3 = D-Tyr] Three Letter Code: Nal-Gly-Tyr-Arg-Arg
Labeling Target	C-X-C chemokine receptor type 4 (CXCR4)
Application	CXCR4 antagonist (IC50 = 126 nM). Displays anti-HIV activity in assays using NL4-3 and IIIB strains (EC50 = 21 nM for both strains).
Appearance	Crystalline solid
Purity	≥95%
Activity	Antagonist
Biological Activity	FC131 (cyclo (-D-Tyr-Arg-Arg-Nal-Gly-)) is a selective, cyclopentapeptide CXCR4 antagonist with IC50 of 126nM, exhibits anti-HIV activity in assays using NL4-3 and IIIB strains with EC50 of 21nM.
Target	CXCR

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