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Peptide YY (human) Acetate

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PYY; Peptide YY; C16118
118997-30-1 (net)
H-Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2 acetate salt
Molecular Formula
Long-term Storage Conditions
Peptide YY (PYY) plays an important role in regulating gastrointestinal secretion and motility.
Peptide YY (PYY) is a gut hormone which is primarily released from endocrine cells of the distal digestive tract in proportion to both the calorie content of a meal and its energy source composition.
Areas of Interest
Hormonal therapy
  • Background
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Peptide YY (PYY) also known as peptide tyrosine tyrosine is a peptide that in humans is encoded by the PYY gene. Peptide YY is a short (36-amino acid) peptide released from cells in the ileum and colon in response to feeding. In the blood, gut, and other elements of periphery, PYY acts to reduce appetite; similarly, when injected directly into the central nervous system, PYY is also anorexigenic, i.e., it reduces appetite. Peptide YY can be produced as the result of enzymatic breakdown of crude fish proteins and ingested as a food product.

CAS: 24305-27-9
Sequence: Pyr-His-Pro-NH2
M.W: 362.41
Molecular Formula: C16H22N6O4
CAS: 25126-32-3 (net)
Sequence: H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 ammonium salt
M.W: 1143.3
Molecular Formula: C49H62N10O16S3
CAS: 38916-34-6 (net), 51110-01-1 (acetate)
Sequence: H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH acetate salt (Disulfide bond)
M.W: 1637.88
Molecular Formula: C76H104N18O19S2
CAS: 75957-60-7 (net), 105184-37-0 (acetate)
Sequence: H-Arg-Lys-Glu-Val-Tyr-OH acetate salt
M.W: 813.89
Molecular Formula: C35H59N9O13
CAS: 103300-74-9
Sequence: (1-methyl-4,5-dihydroorotyl)- His-Pro-NH2
M.W: 477.46
Molecular Formula: C17H23N7O5

The gut-brain axis refers to the bidirectional communication between the gut and the brain. Four information carriers (vagal and spinal afferent neurons, immune mediators such as cytokines, gut hormones and gut microbiota-derived signalling molecules) transmit information from the gut to the brain, while autonomic neurons and neuroendocrine factors carry outputs from the brain to the gut. The members of the neuropeptide Y (NPY) family of biologically active peptides, NPY, peptide YY (PYY) and pancreatic polypeptide (PP), are expressed by cell systems at distinct levels of the gut-brain axis. PYY and PP are exclusively expressed by endocrine cells of the digestive system, whereas NPY is found at all levels of the gut-brain and brain-gut axis.

Holzer, P., Reichmann, F., & Farzi, A. (2012). Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut–brain axis. Neuropeptides, 46(6), 261-274.

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