Peptide YY (PYY) is a gut hormone which is primarily released from endocrine cells of the distal digestive tract in proportion to both the calorie content of a meal and its energy source composition.
CAT No: 10-101-97
CAS No:118997-30-1 (net)
Synonyms/Alias:PYY; Peptide YY; C16118
The gut-brain axis refers to the bidirectional communication between the gut and the brain. Four information carriers (vagal and spinal afferent neurons, immune mediators such as cytokines, gut hormones and gut microbiota-derived signalling molecules) transmit information from the gut to the brain, while autonomic neurons and neuroendocrine factors carry outputs from the brain to the gut. The members of the neuropeptide Y (NPY) family of biologically active peptides, NPY, peptide YY (PYY) and pancreatic polypeptide (PP), are expressed by cell systems at distinct levels of the gut-brain axis. PYY and PP are exclusively expressed by endocrine cells of the digestive system, whereas NPY is found at all levels of the gut-brain and brain-gut axis.
Holzer, P., Reichmann, F., & Farzi, A. (2012). Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut–brain axis. Neuropeptides, 46(6), 261-274.
2. High fat diet and GLP-1 drugs induce pancreatic injury in mice
4. Implications of ligand-receptor binding kinetics on GLP-1R signalling
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