Peptide YY (PYY) is a gut hormone which is primarily released from endocrine cells of the distal digestive tract in proportion to both the calorie content of a meal and its energy source composition.
CAT No: 10-101-97
CAS No:118997-30-1 (net)
Synonyms/Alias:PYY; Peptide YY; C16118
Peptide YY (human) Acetate is a synthetic form of the naturally occurring gut hormone Peptide YY, which is predominantly secreted by L-cells in the distal gastrointestinal tract. This peptide is composed of 36 amino acids and exhibits a high degree of structural homology with other members of the pancreatic polypeptide family. Known for its role in modulating digestive processes and appetite regulation, Peptide YY (human) Acetate has become a valuable tool in biochemical and physiological research. Its unique sequence and biological activity make it an essential compound for investigating the intricate signaling pathways that govern energy homeostasis, gastrointestinal function, and metabolic regulation.
Appetite Regulation Studies: Researchers utilize Peptide YY (human) Acetate to investigate the molecular mechanisms underlying appetite control and satiety signaling. By administering this peptide to in vitro or in vivo models, scientists can observe its interaction with Y2 receptors in the hypothalamus and other regions of the brain. These studies elucidate how Peptide YY influences food intake, meal size, and feeding behaviors, providing insights into the central and peripheral pathways that mediate hunger and fullness. Such research is fundamental for advancing the understanding of obesity, eating disorders, and metabolic syndrome.
Gastrointestinal Motility Research: PYY Acetate plays a significant role in the study of gastrointestinal motility and transit. It is frequently employed in experimental models to assess its inhibitory effects on gastric emptying and intestinal transit time. By modulating the release and action of various gut peptides and neurotransmitters, Peptide YY helps clarify the complex regulatory networks that coordinate digestive processes. These investigations are critical for identifying potential therapeutic targets for gastrointestinal motility disorders, such as irritable bowel syndrome and functional dyspepsia.
Endocrine and Metabolic Pathway Analysis: Scientists leverage Peptide YY (human) Acetate to dissect its impact on endocrine signaling and metabolic regulation. Studies often focus on its ability to influence insulin secretion, glucose homeostasis, and lipid metabolism through interactions with pancreatic islets and peripheral tissues. By mapping the downstream effects of PYY on hormonal cascades, researchers gain a deeper understanding of its role in metabolic diseases, energy expenditure, and nutrient partitioning. These findings contribute valuable knowledge to the broader field of endocrinology and metabolic research.
Neurobiology of Feeding Behavior: The use of Peptide YY in neurobiology extends to examining its effects on neural circuits involved in reward, motivation, and behavioral responses to food stimuli. Experimental approaches may involve electrophysiological recordings, imaging techniques, or behavioral assays to track how PYY modulates neuronal activity and synaptic plasticity. This line of inquiry sheds light on the neurochemical basis of feeding behavior, the interplay between gut hormones and the central nervous system, and the potential for targeting these pathways in the context of addiction or maladaptive eating patterns.
Pharmacological and Receptor Binding Studies: Peptide YY (human) Acetate serves as a reference ligand in pharmacological research aimed at characterizing Y receptor subtypes and their physiological relevance. Radiolabeled or fluorescently tagged versions of the peptide enable quantitative binding assays and receptor mapping in various tissues. These studies are instrumental in the development and screening of novel receptor agonists or antagonists, facilitating the discovery of compounds with potential applications in appetite modulation, metabolic control, and gastrointestinal therapeutics.
Through its diverse applications, Peptide YY (human) Acetate continues to drive innovation and discovery in the fields of endocrinology, neuroscience, and gastrointestinal biology. Its versatility as a research reagent allows for the exploration of fundamental physiological processes and the identification of novel molecular targets. By enabling detailed studies on appetite regulation, gut motility, metabolic pathways, neural circuits, and receptor pharmacology, this peptide provides a robust platform for advancing scientific knowledge and informing future therapeutic strategies.
The gut-brain axis refers to the bidirectional communication between the gut and the brain. Four information carriers (vagal and spinal afferent neurons, immune mediators such as cytokines, gut hormones and gut microbiota-derived signalling molecules) transmit information from the gut to the brain, while autonomic neurons and neuroendocrine factors carry outputs from the brain to the gut. The members of the neuropeptide Y (NPY) family of biologically active peptides, NPY, peptide YY (PYY) and pancreatic polypeptide (PP), are expressed by cell systems at distinct levels of the gut-brain axis. PYY and PP are exclusively expressed by endocrine cells of the digestive system, whereas NPY is found at all levels of the gut-brain and brain-gut axis.
Holzer, P., Reichmann, F., & Farzi, A. (2012). Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut–brain axis. Neuropeptides, 46(6), 261-274.
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