Pergolide Mesylate Salt

Pergolide mesylate salt is a methanesulfonate salt obtained from pergolide by mixing eqimolar amount of pergolide and methanesulfonic acid. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used in the management of Parkinson's disease and hyperprolactinemia.

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Pergolide Mesylate is a semi-synthetic ergot derivative and a dopamine agonist with antiparkinson property. Pergolide mesylate binds to and activates dopamine receptor subtypes D1 and D2, resulting in prolactin secretion inhibition, transient increase in serum concentration of growth hormone, and decrease in serum concentration of luteinizing hormone. Direct stimulation of postsynaptic dopamine receptors in the nigrostriatal system, may account for this agent's antiparkinson activity.  >> Read More

Synonyms/AliasPergolide Mesilate; LY 127809; (8β)-8-[(Methylthio)methyl]-6-propylergoline monomethanesulfonate; 8-Methylsulfanylmethyl-6-propyl-ergoline methanesulfonate
Labeling TargetDopamine Receptor
ApplicationDopaminergic agonist & Suppress pituitary secretion of prolactin & Anti-Parkinsonian agent.
Areas of InterestNeurological Disease
TargetDopamine Receptor
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