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Triptorelin pamoate is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
| CAT# | 10-101-101 |
| CAS | 57773-63-4 (net), 124508-66-3 (pamoate salt) |
| Synonyms/Alias | 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycine amide, 4,4'-methylenebis(3-hydroxy-2-naphthoate) (salt); Decapeptyl; Diphereline; Gonapeptyl; Luteinizing hormone-releasing factor (swine), 6-D-tryptophan-, 4,4'-methylenebis(3-hydroxy-2-naphthalenecarboxylate) (salt); Pamorelin; Trelstar; Trelstar depot; Trelstar LA; Triptorelin embonate; UNII-08AN7WA2G0 |
| M.F/Formula | C64H82N18O13 |
| M.W/Mr. | 1744.96 |
| Sequence | Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 |
| Labeling Target | Gonadotropin-releasing hormone (GNRH) Receptor |
| Application | Triptorelin pamoate is classified as a gonadotropin releasing hormone (GnRH) agonist. In adult men with advanced prostate cancer, triptorelin pamoate can be used to help lower testosterone levels, which can be beneficial in stopping or slowing the growth of abnormal prostate tissue. |
| Activity | Agonist |
| Biological Activity | Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. |
| Areas of Interest | Cancer Research Pituitary & Hypothalamic Hormones Veterinary Medicine |
| Functions | Peptide binding |
| Disease | Advanced Prostatic Carcinoma |
| Target | Gonadotropin-releasing hormone (GnRH) |
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