Pramlintide is an analogue of amylin, a small peptide hormone that is released into the bloodstream by the β-cells of the pancreas along with insulin, after a meal. Like insulin, amylin is completely absent in individuals with Type I diabetes.

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Synonyms/AliasAC 0137; AC 137; Symlin; Tripro-Amylin; riproamylin; Pramlintide; LS-181996; LS181996; Amylin
SequenceLys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2(Disulfide bridge cys2 and cys7)
Labeling TargetAmylin receptor
ApplicationPramlintide (Symlin) has been approved by the FDA as a new injectable drug for diabetes (both type 1 and 2).
Biological ActivityPramlintide is a polypeptide analogue of human amylin. Pramlintide, an antidiabetic agent, is antineoplastic in colorectal cancer.
Areas of InterestMetabolic Disease
FunctionsReceptor activity
DiseaseType 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
TargetCalcitonin receptor
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