Mecasermin, also known as recombinant human insulin-like growth factor-1 (rhIGF-1), is a recombinant form of human insulin-like growth factor 1 (IGF-I) which is used in the long-term treatment of growth failure and short stature in children with severe primary IGF-I deficiency, for instance due to growth hormone deficiency or Laron syndrome (growth hormone insensitivity).
CAT No: 10-101-335
CAS No:68562-41-4
Synonyms/Alias:FK-780; Recombinant human insulin-like growth factor-1; rhIGF-1; Somatomedin-1
Mecasermin is a recombinant human insulin-like growth factor 1 (rhIGF-1), a peptide compound that plays a pivotal role in cellular growth, differentiation, and metabolic regulation. As a bioactive analog of endogenous IGF-1, it is structurally and functionally relevant to a range of physiological processes, especially those mediated by the IGF signaling axis. The molecule's ability to engage with the IGF-1 receptor and modulate downstream pathways has made it a valuable tool in fundamental and applied biochemical research. Its recombinant production ensures high sequence fidelity, enabling precise studies of IGF-1-dependent mechanisms across diverse experimental models.
Cellular signaling research: Mecasermin is widely utilized as a reference molecule for dissecting IGF-1 receptor-mediated signaling cascades in cell biology. By providing a consistent and bioactive IGF-1 stimulus, it facilitates the investigation of receptor activation, phosphorylation events, and downstream effectors such as the PI3K/Akt and MAPK/ERK pathways. Researchers employ it to elucidate the molecular basis of cell proliferation, survival, and differentiation, thereby advancing the understanding of growth factor-regulated cellular physiology.
Metabolic regulation studies: The compound serves as a critical reagent in exploring the metabolic effects of IGF-1 in hepatic, muscular, and adipose tissue models. Its application allows scientists to probe mechanisms underlying glucose uptake, glycogen synthesis, and lipid metabolism, particularly in contexts where insulin and IGF-1 pathways intersect. These studies provide insights into anabolic processes, energy homeostasis, and the interplay between growth factors and metabolic health.
Tissue development and regeneration models: Mecasermin is frequently employed in experimental systems designed to study tissue growth, repair, and regeneration. By acting as a potent mitogen, it supports investigations into the proliferation and differentiation of various cell types, including myocytes, chondrocytes, and osteoblasts. Its use in organoid cultures and tissue engineering platforms enables researchers to model developmental processes and assess the impact of IGF-1 signaling on tissue architecture and function.
Peptide structure-function analysis: As a well-characterized recombinant peptide, Mecasermin provides a benchmark for structure-activity relationship (SAR) studies within the IGF protein family. Researchers leverage its defined sequence and bioactivity to compare native and modified IGF-1 analogs, evaluate receptor binding affinities, and investigate the influence of specific amino acid substitutions on biological function. These analyses are essential for advancing peptide engineering and understanding the determinants of IGF-1 receptor specificity.
Pharmacological screening and assay development: The compound is instrumental in the development and validation of bioassays targeting the IGF-1 axis. It is used as a standard in high-throughput screening platforms to assess the efficacy of small molecules, antibodies, or other modulators that influence IGF-1 receptor activity. By providing a reproducible and quantifiable growth factor stimulus, it underpins robust assay design and facilitates the discovery of novel agents that modulate IGF-1-dependent pathways for research purposes.
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