Ganirelix acetate (or diacetate), sold under the brand names Orgalutran and Antagon among others, is an injectable competitive gonadotropin-releasing hormone antagonist (GnRH antagonist). It is primarily used in assisted reproduction to control ovulation.
CAT No: HB00123
CAS No:129311-55-3
Synonyms/Alias:Ganirelix acetate;129311-55-3;Ganirest;Antagon;Ganirelix Acetate Injection;Ganirelix acetate [USAN];Ganirelix (acetate);UNII-56U7906FQW;RS-26306;56U7906FQW;D-Alaninamide,N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]-L-lysyl-L-prolyl-, diacetate (salt);RS-26306-298;Orgalutran;N-Acetyl-3-(2-naphthyl)-D-alanyl-p-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-N(sup 6)-(N,N'-diethylamidino)-D-lysyl-L-leucyl-N(sup 6)-(N,N'-diethylamidino)-L-lysyl-L-prolyl-D-alaninamide diacetate (salt);GANIRELIX ACETATE (MART.);GANIRELIX ACETATE [MART.];Fyremadel;ganirelix diacetate;Ganirest (TN);Orgalutran TFA Salt;Ganirelix (acetate)?;GANIRELIX ACETATE [MI];Ganirelix acetate (JAN/USAN);GANIRELIX ACETATE [JAN];Org-37462;CHEMBL5314377;GANIRELIX ACETATE [VANDF];Ganirelix acetate injection (TN);GANIRELIX ACETATE [WHO-DD];AKOS025394292;AT41856;FG23647;GANIRELIX ACETATE [ORANGE BOOK];HY-109532;D04302;Q27261435;D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N(sup 6)-((ethylamino)(ethylimino)methyl)-D-lysyl-L-leucyl-N(sup 6)-((ethylamino)(ethylimino)methyl)-L-lysyl-L-prolyl-, diacetate (salt);N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene ]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]-L-lysyl-L-prolyl-D-alaninamide;N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-N6-(N,N'diethycarbamimidoyl)-D-lysyl-L-leucyl-N6-(N,N'diethycarbamimidoyl)-L-lysyl-L-prolyl-D-alaninamide diacetate;
Ganirelix Acetate is a synthetic decapeptide belonging to the class of gonadotropin-releasing hormone (GnRH) antagonists, distinguished by its high affinity and specificity for the GnRH receptor. Structurally modified to enhance stability and biological activity, it effectively inhibits the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by competitively blocking endogenous GnRH action at the pituitary level. Its unique biochemical properties make it a valuable tool in reproductive biology, endocrinology, and peptide receptor studies, where precise modulation of the hypothalamic-pituitary-gonadal axis is required for experimental investigation.
Endocrine Regulation Studies: As a potent GnRH antagonist, Ganirelix Acetate is widely employed in research focused on the physiological regulation of the hypothalamic-pituitary-gonadal axis. By selectively suppressing the release of gonadotropins, it enables researchers to dissect the molecular mechanisms underlying feedback loops and hormonal control within the reproductive system. Its use facilitates the investigation of downstream effects resulting from acute or chronic inhibition of GnRH signaling, supporting studies in both basic and applied endocrinology.
Peptide Receptor Pharmacology: The compound serves as a model antagonist for examining the structure-activity relationships and binding dynamics of GnRH receptors. Its well-characterized interaction profile allows for detailed pharmacological profiling, including affinity measurements, receptor occupancy studies, and competitive binding assays. Researchers utilize it to benchmark novel GnRH analogs, validate receptor-targeted screening assays, and explore the nuances of peptide-receptor engagement in vitro and ex vivo systems.
Reproductive Biology Research: In experimental protocols seeking to modulate reproductive hormone levels, Ganirelix Acetate provides a reliable means of inducing reversible suppression of LH and FSH secretion. This property is particularly valuable in studies investigating follicular development, ovulation mechanisms, and the temporal dynamics of gonadotropin-dependent processes. By enabling controlled manipulation of the reproductive axis, it supports the elucidation of hormonal regulation and gametogenesis pathways in animal and cellular models.
Peptide Synthesis and Analytical Method Development: As a chemically defined synthetic peptide, Ganirelix Acetate is utilized as a reference standard and positive control in analytical method validation for peptide quantification and purity assessment. Its consistent structure and robust chromatographic properties make it suitable for calibrating high-performance liquid chromatography (HPLC), mass spectrometry, and related peptide analysis techniques. Laboratories leverage its predictable behavior to optimize peptide detection protocols and ensure data reproducibility across diverse analytical workflows.
Signal Transduction and Cellular Pathway Analysis: The ability of Ganirelix Acetate to modulate GnRH receptor-mediated signaling cascades makes it a valuable reagent for probing downstream cellular pathways. Researchers employ it to selectively inhibit GnRH-induced intracellular events, such as calcium mobilization, kinase activation, and gene expression changes. These studies contribute to a deeper understanding of G protein-coupled receptor (GPCR) signaling mechanisms, receptor desensitization, and the broader landscape of peptide hormone action in cellular systems.
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