Phosphorylation Site-Detector Connexin 43

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Peptide Library Construction and Screening

Powerful screening tools in biological and chemical research

ApplicationPhosphosite detection, Substrate identification
PurityFree of truncated sequences
Areas of InterestKinase
Size1 peptide microarray (each peptide is deposited 3x per subarray, 4 subarrays per slide) + dummy slide and spacers (needed for incubation)
SwissProt IDP17302
FormatPeptides immobilized onto glass slide (3 x 1 inches; 75 by 25 mm)
NumberOfPeptides94
OrganismHomo sapiens (Human)
SpecificationsPeptide scan (13 mers with 10 aa overlap)
Protein Length382
Protein NameConnexin 43
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    Carbetocin is a long-acting synthetic agonist analogue of human oxytocin, with antihemorrhagic and uterotonic activities. Upon administration, carbetocin targets, binds to and activates peripheral oxytocin receptors that are present on the smooth musculature of the uterus. This causes uterus contractions and prevents excessive bleeding after childbirth, particularly following Cesarean section, and may be used to decrease blood loss during hysteroscopic myomectomy.

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    Cetrorelix Acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist (IC50 = 1.21 nM). It can suppress production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland which inhibits ovulation, exhibit antiproliferative effects and display efficacy against hormone-sensitive cancers in vivo. It is often used to treat hormone-sensitive cancers of the prostate and breast.

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    Teriparatide(recombinant human parathyroid hormone) /PTH (1-34) (human) corresponds to the N-terminal part of human parathyroid hormone, a peptide consisting of 84 amino acids.

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    Elcatonin acetate inhibits the absorption and autolysis of bones, thus leads to blood calcium descending. In addition, it inhibits the bone salts dissolving and transferring and promotes the excretion of calcium and phosphorus in urine.

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    Icatibant (Firazyr) is a synthetic peptidomimetic drug consisting of ten amino acids, and acts as an effective and specific antagonist of bradykinin B2 receptors. It has been approved in the EU for use in hereditary angioedema, and is under investigation for a number of other conditions in which bradykinin is thought to play a significant role.

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