Plecanatide

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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CAT#10-101-170
ExplanationPlecanatide is a minimally absorbed agonist of guanylate cyclase C receptors in the intestine and is used for treatment of chronic constipation and irritable bowel syndrome. Plecanatide has not been linked to serum enzyme elevations during treatment or to episodes of clinically apparent liver injury.
Synonyms/Alias(Des-Gly10,D-His(Bzl)6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt Supprelin la Vantas Histrelin acetate
M.F/FormulaC66H86N18O12.XC2H4O2
M.W/Mr.1383.58
ActivityAgonist
Biological ActivityPlecanatide is a guanylate cyclase C agonist mechanistically similar to linaclotide.
TargetGuanylate Cyclase-C
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