Plecanatide is a minimally absorbed agonist of guanylate cyclase C receptors in the intestine and is used for treatment of chronic constipation and irritable bowel syndrome. Plecanatide has not been linked to serum enzyme elevations during treatment or to episodes of clinically apparent liver injury.
CAT No: 10-101-170
CAS No:467426-54-6
Synonyms/Alias:PLECANATIDE;Trulance;Guanilib;467426-54-6;UNII-7IK8Z952OK;plecanatida;Plecanatide [USAN:INN];7IK8Z952OK;HSDB 8405;SP-304 (SYNERGY);DTXSID60196933;(3-Glutamic acid(D>E))human uroguanylin (UGN);467426-54-6 (free base);L-Leucine, L-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-cysteinyl-L-alpha-glutamyl-L-leucyl-L- cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4->12),(7->15)-bis(disulfide);(3-Glutamic acid(D>E))human uroguanylin;[3-glutamic acid(D>E)]human uroguanylin;plecanatidum;Plecanatide (Standard);TrulanceImmediate release;GTPL9069;CHEMBL2103867;A06AX07;DTXCID00119424;GLXC-26182;EX-A4131;AT41877;DB13170;HY-108741R;DA-56928;ASN-ASP-GLU-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU CYCLIC (4->12),(7->15)-BIS(DISULFIDE);L-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-cysteinyl-L-alpha-Glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-leucine cyclic (4-->12),(7-->15)-bis(disulfide);L-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-cysteinyl-L-alpha-Glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-leucine cyclic (4adagger?2),(7adagger?5)-bis(disulfide);L-LEUCINE, L-ASPARAGINYL-L-alpha-ASPARTYL-L-alpha-GLUTAMYL-L-CYSTEINYL-L-alpha-GLUTAMYL-L-LEUCYL-L-CYSTEINYL-L-VALYL-L-ASPARAGINYL-L-VALYL-L-ALANYL-L-CYSTEINYL-L-THREONYLGLYCYL-L-CYSTEINYL-, CYCLIC (4-12),(7-15)-BIS(DISULFIDE);
Plecanatide is a synthetic peptide analog structurally related to uroguanylin, a member of the guanylate cyclase-C (GC-C) agonist family. As a 16-amino acid peptide, it mimics endogenous peptide hormones involved in regulating intestinal fluid and electrolyte homeostasis via the GC-C receptor pathway. Its biochemical architecture and receptor specificity make plecanatide a valuable tool for probing cyclic GMP-mediated signaling and epithelial ion transport mechanisms. Researchers and industry professionals utilize plecanatide in various experimental models to dissect enteric physiology, evaluate receptor pharmacology, and support the development of novel peptide-based technologies.
Receptor Pharmacology: In vitro studies often employ plecanatide to characterize the pharmacodynamics of GC-C receptor activation. By selectively stimulating this receptor, it enables detailed analysis of downstream signaling events, including cyclic GMP production and protein kinase G activation. Such investigations are critical for elucidating the molecular basis of epithelial ion transport, barrier function, and fluid balance, thereby advancing the understanding of gastrointestinal physiology and related disorders at the cellular level.
Signal Transduction Research: Plecanatide serves as a model peptide for dissecting the molecular mechanisms underlying cGMP-dependent signal transduction. Its well-defined structure and receptor selectivity allow researchers to map the cascade of events triggered by GC-C engagement, from second messenger generation to transcriptional regulation and cellular response. These studies contribute to the broader knowledge of peptide hormone signaling and its implications for epithelial cell biology and mucosal homeostasis.
Peptide Structure-Activity Relationship (SAR) Studies: The analog's defined sequence and functional motifs make it a valuable standard in SAR investigations. Researchers utilize plecanatide to systematically modify peptide domains and assess the impact on receptor affinity, efficacy, and metabolic stability. Such work informs the rational design of next-generation peptide agonists, supports the optimization of bioactive peptides for research applications, and enhances the understanding of structure-function relationships in the guanylin family.
Analytical Method Development: Plecanatide is frequently used as a reference standard in the development and validation of analytical assays for peptide quantification, purity assessment, and stability testing. Its physicochemical properties and reproducible chromatographic behavior facilitate the calibration of liquid chromatography-mass spectrometry (LC-MS) and high-performance liquid chromatography (HPLC) methods. These analytical platforms are essential for quality control in peptide synthesis, formulation, and research reagent manufacturing.
Peptide Formulation and Delivery Research: Due to its stability profile and receptor specificity, plecanatide is employed in studies focused on peptide formulation, encapsulation, and targeted delivery. Investigators examine its compatibility with various excipients, delivery vehicles, and release systems to optimize bioavailability and functional retention. Insights gained from these experiments inform the advancement of peptide-based delivery technologies and contribute to the broader field of biopharmaceutical formulation science.
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