This peptide is derived from amino acid residues 57-68 of a9-gliadin and represents an immunodominant epitope that has been shown to elicit HLA-DQ2-restricted T-cell responses in celiac patients. This epitope is resistant to pancreatic proteolysis.
Registration of APIs CMC information required for an IND
IND and NDA support Drug master files (DMF) filing
M.W/Mr. | 1455.8 |
Sequence | One Letter Code: QLQPFPQPQLPY Three Letter Code: H-Gln-Leu-Gln-Pro-Phe-Pro-Gln-Pro-Gln-Leu-Pro-Tyr-OH |
References | 1. Arentz-Hansen, H. et al. J Exp Med 191, 603 (2000). 2. Hausch, F. et al. Am J Physiol Gastrointest Liver Physiol 283, 996 (2002). 3. Mamone, G. et al. J Chromatogr B 855, 236 (2007). |
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