Antagonist G

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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Chemical Structure
ExplanationAntagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy.
SequenceOne Letter Code: RW-{Me-Phe}-WLM-NH2
Biological ActivityAntagonist G is a substance P analog that is a broad spectrum neuropeptide antagonist and antiproliferative agent.
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