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Antagonist G

Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Antagonist G(CAS 115150-59-9)

CAT No: 10-101-206

CAS No:115150-59-9

Synonyms/Alias:Antagonist G;115150-59-9;(2S)-2-[[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]-methylamino]-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]-4-methylpentanamide;L-Methioninamide, L-arginyl-D-tryptophyl-N-methyl-L-phenylalanyl-D-tryptophyl-L-leucyl-;antagonist-g;RWFWLM;RW-N(Me)F-Wlm-NH2;Arg-trp-N-methyl-phe-trp-leu-met-NH2;H-Arg-D-trp-N(Me)phe-D-trp-leu-met-NH2;an-tagonist g;Antagonist G?;Arginyl-tryptophyl-N-methylphenylalanyl-tryptophyl-leucyl-methioninamide;L-Arginyl-O-tryptophyl-N-methyl-L-phenylalanyl-D-tryptophyl-L-leucyl-L-methioninamide;(Arg6,D-Trp7.9,N-Me-Phe8)-Substance P (6-11);CHEMBL4303227;HY-P1185;MFCD00133831;AKOS024456877;L-Methioninamide, L-arginyl-O-tryptophyl-N-methyl-L-phenylalanyl-D-tryptophyl-L-leucyl-;DA-59542;MS-31778;CS-0028917;ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2;G12365;(Arg6,D-Trp7?9,N-Me-Phe8)-Substance P (6-11);BRD-K25863791-001-01-8;(S)-N-((5S,8S,11R,14S,17R)-11-((1H-indol-3-yl)methyl)-14-benzyl-5-carbamoyl-18-(1H-indol-3-yl)-8-isobutyl-15-methyl-7,10,13,16-tetraoxo-2-thia-6,9,12,15-tetraazaoctadecan-17-yl)-2-amino-5-guanidinopentanamide;

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M.F/Formula
C49H66N12O6S
M.W/Mr.
951.2
Sequence
One Letter Code:RWFWLM
Three Letter Code:H-Arg-D-Trp-N(Me)Phe-D-Trp-Leu-Met-NH2
Activity
Antagonist
Biological Activity
Antagonist G is a substance P analog that is a broad spectrum neuropeptide antagonist and antiproliferative agent.
Target
vasopressin
Length
11
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C49H66N12O6S/c1-29(2)23-39(45(64)57-38(43(51)62)20-22-68-4)58-46(65)40(25-31-27-55-36-18-10-8-15-33(31)36)59-47(66)42(24-30-13-6-5-7-14-30)61(3)48(67)41(26-32-28-56-37-19-11-9-16-34(32)37)60-44(63)35(50)17-12-21-54-49(52)53/h5-11,13-16,18-19,27-29,35,38-42,55-56H,12,17,20-26,50H2,1-4H3,(H2,51,62)(H,57,64)(H,58,65)(H,59,66)(H,60,63)(H4,52,53,54)/t35-,38-,39-,40+,41+,42-/m0/s1
InChI Key
CUCSSYAUKKIDJV-FAXBSAIASA-N

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