This peptide is a fragment of the human aquaporin-2 (AQP2) phosphorylated at Ser261. Protein phosphorylation plays a key role in vasopressin signaling in renal-collecting duct. Phosphorylation at several AQP2 residues including Ser256 and Ser261, is altered in response to vasopressin. It is possible that both sites are involved in vasopressin-dependent AQP2 trafficking.
Registration of APIs CMC information required for an IND
IND and NDA support Drug master files (DMF) filing
M.W/Mr. | 1713.8 |
Sequence | One Letter Code: RQSVELH-pS-PQSLPR Three Letter Code: H-Arg-Gln-Ser-Val-Glu-Leu-His-pSer-Pro-Gln-Ser-Leu-Pro-Arg-OH |
References | 1. Nielsen, S. et al. PNAS 90, 11663 (1993); 2. Hoffert, J. et al. PNAS 103, 7159 (2006). |
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