Corticorelin ovine triflutate is a 41 amino-acid peptide similar to human corticotropin-releasing hormone (CRH). It is a potent stimulator of adrenocorticotropic hormone (ACTH).
CAT No: 10-101-76
CAS No:79804-71-0 (net)
Synonyms/Alias:Corticorelin ovine; Ovine CRH; Ovine CRF 41; Ovine corticotropin-releasing factor;Corticotropin-releasing factor (Ovine) (acetate); Ovine CRF acetate; Ovine corticotropin-releasing factor acetate
Chemical Name:(4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoic acid
CRF (ovine) Trifluoroacetate, also known as Corticotropin-Releasing Factor from ovine sources in its trifluoroacetate salt form, is a synthetic peptide that plays a pivotal role in neuroendocrinology and stress-related biochemical research. As a highly conserved neuropeptide, CRF is fundamental to the regulation of the hypothalamic-pituitary-adrenal (HPA) axis, orchestrating the body's response to stress by stimulating the release of adrenocorticotropic hormone (ACTH). The ovine sequence is frequently utilized in laboratory settings due to its well-characterized structure and robust biological activity, making it a standard reference material for experimental studies involving peptide hormones and neuroregulation.
Neuroendocrine research: CRF (ovine) Trifluoroacetate is extensively applied in neuroendocrine studies to elucidate the mechanisms governing stress response and hormonal regulation. By serving as a reliable agonist of CRF receptors, it enables researchers to probe the activation and downstream signaling pathways of the HPA axis. The peptide's ability to mimic endogenous CRF activity facilitates investigations into the molecular and cellular processes underlying neurohormonal communication, offering valuable insights into stress physiology and adaptive responses.
Receptor binding assays: In pharmacological and biochemical research, this peptide is frequently utilized in receptor binding studies to characterize the affinity, specificity, and functional properties of CRF receptors, particularly CRF1 and CRF2 subtypes. Through competitive binding experiments and radioligand displacement assays, it provides a benchmark for evaluating novel ligands, antagonists, or receptor modulators, supporting drug discovery and receptor pharmacology efforts.
Peptide functional studies: CRF (ovine) Trifluoroacetate serves as a crucial tool in functional assays aimed at dissecting peptide-mediated signaling events. Its defined sequence and reproducible activity allow for precise modulation of CRF receptor pathways in vitro and ex vivo systems. Researchers leverage these properties to study intracellular signaling cascades, gene expression changes, and peptide-induced physiological responses, advancing the understanding of neuropeptide function and regulation.
In vivo modeling: The compound is instrumental in animal models designed to investigate stress, anxiety, and neurobehavioral phenomena. Administration of the peptide in controlled experimental settings enables the simulation of acute or chronic stress paradigms, facilitating the study of behavioral, endocrine, and neurochemical outcomes. Such models are foundational for exploring the biological basis of stress-related disorders and for validating hypotheses about neuropeptide involvement in complex behaviors.
Analytical method development: CRF (ovine) Trifluoroacetate is often employed as a reference standard or calibration material in the development and validation of analytical methods for peptide quantification. Its well-characterized properties support the optimization of high-performance liquid chromatography (HPLC), mass spectrometry, and immunoassay protocols, ensuring accuracy and reproducibility in peptide detection and measurement. This role is essential for laboratories establishing robust workflows for neuropeptide analysis in various biological matrices.
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