DAMME
DAMME is a stable synthetic analog of methionine enkephalin. Actions are similar to those of methionine enkephalin. It can be reversed by narcotic antagonists such as naloxone. It is one of the best-known analogs that has undergone fairly extensive clinical testing.
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| CAT# | 10-101-79 |
| CAS | 64854-64-4 (net) |
| Synonyms/Alias | D-Ala(2); MePhe(4); Met(0)-ol-enkephalin; FK 33-824; FK-33-824; FK-33824; CID11758339; DL-tyrosyl-DL-alanyl-glycyl-N-methyl-DL-phenylalanyl-S-oxo-DL-methioninol;Tyr Ala Gly MePhe Met OH; Tyr-Ala-Gly-MePhe-Met-OH |
| Chemical Name | 2-amino-N-[1-[[2-[[1-[(1-hydroxy-4-methylsulfinylbutan-2-yl)amino]-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide |
| M.F/Formula | C29H41N5O7S |
| M.W/Mr. | 603.73 |
| Sequence | One Letter Code: YAGFX
Three Letter Code: H-DL-Tyr-DL-Ala-Gly-DL-N(Me)Phe-DL-Met(O)-ol |
| Application | DAMME exerts a potent analgesic effect after systemic administration. |
| Areas of Interest | Analgesics |
| Source# | Synthetic |
Long-term Storage Conditions | ?20°C |
InChI | InChI=1S/C29H41N5O7S/c1-19(32-28(39)24(30)15-21-9-11-23(36)12-10-21)27(38)31-17-26(37)34(2)25(16-20-7-5-4-6-8-20)29(40)33-22(18-35)13-14-42(3)41/h4-12,19,22,24-25,35-36H,13-18,30H2,1-3H3,(H,31,38)(H,32,39)(H,33,40) |
InChI Key | HYZHONGSQNXMPH-UHFFFAOYSA-N |
Canonical SMILES | CC(C(=O)NCC(=O)N(C)C(CC1=CC=CC=C1)C(=O)NC(CCS(=O)C)CO)NC(=O)C(CC2=CC=C(C=C2)O)N |
BoilingPoint | 1033.4±65.0 °C at 760 mmHg |
Melting Point | N/A |
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