PG 106 is a selective antagonist of human melanocortin receptor 3 (hMC3R), and shows no activity at hMC4 receptors and hMC5 receptors. Therefore, it may be used to differentiate the substructural features responsible for selectivity at the hMC3R, hMC4R, and hMC5R.
CAT No: R0980
CAS No:944111-22-2
Synonyms/Alias:944111-22-2;PG106;(3S,6S,9R,16S,24S)-16-(2-Acetamidohexanoylamino)-6-[3-(diaminomethylideneamino)propyl]-3-(1H-indol-3-ylmethyl)-9-(naphthalen-2-ylmethyl)-2,5,8,11,15,18-hexaoxo-1,4,7,10,14,19-hexazacyclotetracosane-24-carboxamide;PG 106 TFA;AKOS024458418;DA-66643;PD079778;
PG 106 is a synthetic peptide compound recognized for its utility in biochemical and molecular research applications. Structurally, it is composed of a defined amino acid sequence, making it a valuable tool for investigating peptide-driven biological processes, receptor interactions, and signaling pathways. Its sequence specificity and stability enable researchers to employ it in controlled experimental systems, facilitating the elucidation of complex molecular mechanisms. PG 106 has gained attention in the scientific community for its role in advancing peptide-based studies, supporting both fundamental research and the development of novel analytical techniques.
Peptide receptor binding studies: PG 106 is frequently utilized in receptor-ligand binding assays to characterize the specificity and affinity of peptide-receptor interactions. By serving as a model ligand, it allows researchers to dissect the molecular determinants of binding, quantify receptor occupancy, and map binding sites. These studies contribute to a deeper understanding of receptor pharmacology, signal transduction, and the design of selective receptor modulators.
Signal transduction research: As a defined peptide sequence, PG 106 is instrumental in probing cellular signaling pathways. Researchers employ it to activate or inhibit specific signaling cascades in vitro, enabling the dissection of downstream molecular events. Its use in these contexts aids in identifying key regulatory nodes, characterizing pathway dynamics, and elucidating the roles of peptide-mediated signaling in cellular physiology.
Peptide synthesis validation: PG 106 serves as a reference standard in the optimization and validation of solid-phase peptide synthesis protocols. Its well-characterized sequence and physicochemical properties make it suitable for benchmarking synthesis efficiency, assessing peptide purity via analytical techniques, and calibrating instrumentation. This application is critical for laboratories seeking to refine synthesis workflows and ensure reproducibility in peptide production.
Analytical method development: The compound is valuable in the development and validation of analytical methods such as high-performance liquid chromatography (HPLC) and mass spectrometry. By providing a defined analyte, PG 106 facilitates the calibration of detection systems, the evaluation of separation parameters, and the establishment of quantitative assays. These efforts support the accurate identification and quantification of peptides in complex biological samples.
Structure-activity relationship (SAR) studies: PG 106 is employed in SAR investigations to explore how specific sequence modifications influence biological activity. Researchers can introduce targeted alterations to the peptide and assess the resulting changes in function, binding affinity, or stability. Insights gained from these studies inform the rational design of novel peptide analogs with optimized properties for research and industrial applications.
1. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
3. High fat diet and GLP-1 drugs induce pancreatic injury in mice
4. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
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