Potent C5a receptor peptide antagonist (IC50 = 31 nM). Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's Disease. Orally active and brain penetrant.
CAT# | 10-101-154 |
CAS | 514814-49-4 |
Synonyms/Alias | PMX-205;Hydrocinnamate |
M.F/Formula | C45H62N10O6 |
M.W/Mr. | 839.05 |
Sequence | Cyclo[N2-(1-Oxo-3-phenylpropyl)-Orn-Pro-D-Cha-Trp-Arg] |
Labeling Target | Complement C5a receptor |
Application | PMX-205 is a potent antagonist of C5a receptor. It is used as anti-inflammatory drug. |
Appearance | Solid powder |
Purity | >98% (or refer to the Certificate of Analysis) |
Activity | Agonist |
Biological Activity | PMX 205 is a potent C5a receptor peptide antagonist (IC50 = 31 nM). |
Areas of Interest | Alzheimer's Disease,Anti-inflammatory |
Functions | Toxic substance binding |
Disease | Irritable bowel syndrome Chronic idiopathic constipation Irritable bowel syndrome characterized by constipation |
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