Octreotide acetate is a longer acting synthetic octapeptide analog of naturally occurring somatostatin. It inhibits the secretion of gastro-entero-pancreatic peptide hormones and the release of growth hormone.
CAT No: 10-101-200
CAS No:173606-11-6
Synonyms/Alias:D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-N6-acetyl-L-lysyl-L-threonyl-N-[(1R, 2R)-2-hydroxy-1-(hydroxymethyl)propyl]-L-Cysteinamide cyclic (2→7)-disulfide
N-Acetyl-Lys-Octreotide is a synthetic peptide analog derived from the naturally occurring hormone somatostatin. Characterized by its distinctive sequence modifications, including an N-acetylated lysine residue, this compound exhibits enhanced metabolic stability and unique receptor-binding properties compared to its parent molecule. Its structural features make it a valuable tool in peptide research, particularly in the study of somatostatin receptor interactions, signal transduction pathways, and peptide engineering. The compound's robust biochemical profile has positioned it as an important resource for scientists investigating peptide-based modulation of cellular processes and receptor pharmacology.
Receptor Binding Studies: N-Acetyl-Lys-Octreotide serves as a reliable probe for elucidating the binding affinities and selectivity profiles of somatostatin receptor subtypes. Its modified structure enables researchers to dissect the nuances of ligand-receptor interactions, facilitating detailed mapping of receptor-ligand interfaces. By employing this analog in binding assays, scientists can generate comparative data to inform the design of next-generation receptor agonists or antagonists, ultimately advancing the understanding of G protein-coupled receptor (GPCR) biology.
Peptide Structure-Activity Relationship (SAR) Analysis: The compound's incorporation of an N-acetylated lysine residue offers a unique vantage point for structure-activity relationship investigations. Researchers utilize it to systematically evaluate how specific sequence alterations influence biological activity, receptor selectivity, and metabolic degradation. Such studies are instrumental in optimizing peptide therapeutics and in the rational design of analogs with tailored pharmacokinetic properties.
Peptide Synthesis and Engineering: N-Acetyl-Lys-Octreotide is frequently employed as a reference standard or template in solid-phase peptide synthesis protocols. Its well-characterized sequence and physicochemical properties provide a benchmark for evaluating synthetic methodologies, purification strategies, and analytical techniques. Additionally, its use as a scaffold in peptide engineering projects supports the generation of novel analogs with improved receptor selectivity, stability, or bioactivity.
Cellular Signaling Research: The compound is a valuable tool for interrogating downstream signaling pathways activated by somatostatin receptors. By applying it to cultured cell systems, investigators can monitor changes in second messenger levels, phosphorylation events, or gene expression profiles in response to receptor engagement. These experiments yield insights into the molecular mechanisms by which somatostatin analogs modulate cellular physiology, informing both basic research and the development of new molecular probes.
Peptide Functional Studies: Beyond its role in receptor pharmacology, N-Acetyl-Lys-Octreotide is utilized in functional assays to assess peptide-mediated effects on cellular proliferation, secretion, and differentiation. Its stability and receptor affinity make it suitable for long-term studies where consistent bioactivity is required. Scientists leverage these properties to explore the broader implications of somatostatin analogs in cell biology, neuroendocrine regulation, and signal modulation, thereby expanding the utility of peptide tools in advanced biochemical research.
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