Ramoplanin is used as a treatment for multiple antibiotic-resistant Clostridium difficile infection of the gastrointestinal tract.
CAT# | 10-101-105 |
CAS | 76168-82-6 |
Background | Ramoplanin, a potent cyclic lipoglycodepsipeptide antibiotic, has been reported to be active against aerobic and anaerobic gram-positive bacteria. Mechanistic studies show that Ramoplanin prevents cell wall peptidoglygan formation and further enzymatic processing via binding to lipid II, a key intermediate moeity. Ramoplanin has also displayed a low affinity for Lipid I, a substrate for the MurG step of cell wall formation. >> Read More |
Synonyms/Alias | Ramoplanin; A 16686; A16686; A-16686; MD 62198; MD62198; MD-62198; MDL62198 |
M.F/Formula | C106H170ClN21O30 |
M.W/Mr. | 2254.06 |
Application | Ramoplanin (INN) is a glycolipodepsipeptide antibiotic drug derived from strain ATCC 33076 of Actinoplanes. It exerts its bacteriocidal effect by inhibiting cell wall biosynthesis, acting by inhibiting the transglycosylation step of peptidoglycan synthesis. |
Biological Activity | Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic derived from the Actinoplanes spp with with activity against gram-positive bacteria. |
Areas of Interest | Infection |
Target | Bacterial |
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