Rotigaptide
Rotigaptide, also called ZP-123, is a peptide analog, which has been shown to increase gap junction intercellular conductance in cardiac muscle cells. Gap junctions are protein channels that are responsible for conducting electrical impulses between cells in the heart to maintain normal rhythm.
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| CAT# | 10-101-55 |
| CAS | 355151-12-1 |
| Synonyms/Alias | CHEMBL450656; GAP-486; ZP-123; ZP 123; ZP123 peptide; ZP-123 (ZEALAND); acetyl-tyrosyl-prolyl-hydroxyprolyl-glycyl-alanyl-glycinamide; GAP486; GAP 486; Rotigaptide. |
| M.F/Formula | C28H39N7O9 |
| M.W/Mr. | 617.65 |
| Sequence | Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2 |
| Labeling Target | Gap junction modulator |
| Application | Rotigaptide is currently under clinical investigation for the treatment of cardiac arrhythmias–specifically atrial fibrillation. |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Biological Activity | Rotigaptide, also known as GAP-486; ZP-123, is a gap junction modulator potentially for the treatment of ventricular tachycardia and atrial. |
| Areas of Interest | Cardiovascular System & Diseases
Pituitary & Hypothalamic Hormones |
| Solubility | Soluble in DMSO |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Short-term Storage Conditions | Dry, dark and at 0 - 4 °C |
Long-term Storage Conditions | -20 °C |
BoilingPoint | 1187.3±65.0 °C at 760 mmHg |
ShelfLife | >2 years if stored properly |
Melting Point | N/A |
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