Rotigaptide

Rotigaptide, also called ZP-123, is a peptide analog, which has been shown to increase gap junction intercellular conductance in cardiac muscle cells. Gap junctions are protein channels that are responsible for conducting electrical impulses between cells in the heart to maintain normal rhythm.

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Rotigaptide(CAS 355151-12-1)

CAT No: 10-101-55

CAS No: 355151-12-1

Synonyms/Alias: Rotigaptide;355151-12-1;ZP-123;ZP-123 (ZEALAND);GAP (WYETH);UNII-GFA1W6KO7N;GFA1W6KO7N;Rotigaptide [USAN:INN];Rotigaptide [USAN];rotigaptida;GAP 484;GAP 486;ZP123;ZP 123;Rotigaptide (USAN);ROTIGAPTIDE [INN];(2R,4S)-1-[(2R)-1-[(2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]-N-[2-[[(2R)-1-[(2-amino-2-oxoethyl)amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]-4-hydroxypyrrolidine-2-carboxamide;Ac-d-Tyr-d-Pro-d-Hyp-Gly-d-Ala-Gly-NH2;Glycinamide, N-acetyl-D-tyrosyl-D-prolyl-(4S)-4-hydroxy-D-prolylglycyl-D-alanyl-;Dipeptide 9f [PMID 19175320];Dipeptide 9f (PMID 19175320);CHEMBL450656;rotigaptidum;GAP-486;(2R)-N-(carbamoylmethyl)-2-(2-(((2R,4S)-1-((2R)-1-((2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl)pyrrolidine-2-carbonyl)-4-hydroxypyrrolidin-2-yl)formamido)acetamido)propanamide;(2R)-N-(carbamoylmethyl)-2-(2-{[(2R,4S)-1-[(2R)-1-[(2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidin-2-yl]formamido}acetamido)propanamide;(2R,4S)-1-((2R)-1-((2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl)pyrrolidine-2-carbonyl)-N-(2-(((2R)-1-((2-amino-2-oxoethyl)amino)-1-oxopropan-2-yl)amino)-2-oxoethyl)-4-hydroxypyrrolidine-2-carboxamide;ZP123 peptide;zp1-23;GTPL9214;DTXCID10111515;CHEBI:230093;Ac-Tyr-Pro-Hyp-Gly-Ala-Gly-NH2;AKOS040742576;DB13067;DA-67291;MS-30756;HY-106225;CS-0025346;NS00071051;D05767;G17110;Q7370547;acetyl-tyrosyl-prolyl-hydroxyprolyl-glycyl-alanyl-glycinamide;N-Acetyl-d-tyrosyl-d-prolyl-(4S)-4-hydroxy-d-prolylglycyl-d-alanylglycinamide;

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M.F/FormulaC28H39N7O9
M.W/Mr.617.7
SequenceOne Letter Code:YPXGAG
Three Letter Code:Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2
Labeling TargetGap junction modulator
ApplicationRotigaptide is currently under clinical investigation for the treatment of cardiac arrhythmias–specifically atrial fibrillation.
AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
Biological ActivityRotigaptide, also known as GAP-486; ZP-123, is a gap junction modulator potentially for the treatment of ventricular tachycardia and atrial.
Areas of InterestCardiovascular System & Diseases
Pituitary & Hypothalamic Hormones
Long-term Storage ConditionsSoluble in DMSO
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage ConditionsDry, dark and at 0 - 4 °C
Solubility-20 °C
InChIInChI=1S/C28H39N7O9/c1-15(25(41)30-12-23(29)39)32-24(40)13-31-26(42)22-11-19(38)14-35(22)28(44)21-4-3-9-34(21)27(43)20(33-16(2)36)10-17-5-7-18(37)8-6-17/h5-8,15,19-22,37-38H,3-4,9-14H2,1-2H3,(H2,29,39)(H,30,41)(H,31,42)(H,32,40)(H,33,36)/t15-,19+,20-,21-,22-/m1/s1
InChI KeyGFJRASPBQLDRRY-TWTQBQJDSA-N
BoilingPoint1187.3±65.0 °C at 760 mmHg
ShelfLife>2 years if stored properly
Melting PointN/A
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