Rotigaptide

Rotigaptide, also called ZP-123, is a peptide analog, which has been shown to increase gap junction intercellular conductance in cardiac muscle cells. Gap junctions are protein channels that are responsible for conducting electrical impulses between cells in the heart to maintain normal rhythm.

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CAT#	10-101-55
CAS	355151-12-1
Background	Rotigaptide (formerly ZP123) is a novel antiarrhythmic peptide that prevents uncoupling of connexin 43 (Cx43)-mediated, gap junction communication during acute metabolic stress. Since rotigaptide's long-term effects on Cx43 are unknown, we studied its effect on Cx43 protein levels at 24 h in neonatal ventricular myocytes. As determined by Western blot analysis, rotigaptide produced a dose-dependent increase in Cx43 protein expression that reached a maximum level at 100 nM. Furthermore, 100 nM rotigaptide markedly increased Cx43 immunoreactivity and Cx43-positive gap junctions as observed in immunocytochemical studies. >> Read More
Synonyms/Alias	CHEMBL450656; GAP-486; ZP-123; ZP 123; ZP123 peptide; ZP-123 (ZEALAND); acetyl-tyrosyl-prolyl-hydroxyprolyl-glycyl-alanyl-glycinamide; GAP486; GAP 486; Rotigaptide.
M.F/Formula	C28H39N7O9
M.W/Mr.	617.65
Sequence	Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2
Labeling Target	Gap junction modulator
Application	Rotigaptide is currently under clinical investigation for the treatment of cardiac arrhythmias–specifically atrial fibrillation.
Appearance	Solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Biological Activity	Rotigaptide, also known as GAP-486; ZP-123, is a gap junction modulator potentially for the treatment of ventricular tachycardia and atrial.
Areas of Interest	Cardiovascular System & Diseases Pituitary & Hypothalamic Hormones

CAT#	Product Name	M.W	Molecular Formula	Inquiry
10-101-25	Brain Natriuretic Peptide, Human	3464.09	C143H244N50O42S4	Inquiry
10-101-53	Eledoisin	1188.4	C54H85N13O15S	Inquiry
10-101-55	Rotigaptide	617.65	C28H39N7O9	Inquiry
10-101-70	Argipressin	1084.21	C46H65N15O12S2	Inquiry
10-101-82	Endothelin-1 (human, bovine, dog, mouse, porcine, rat) Acetate	2491.94	C109H159N25O32S5	Inquiry
10-101-90	Lepirudin	6979.52	C287H440N80O111S6	Inquiry

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Solubility	Soluble in DMSO
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions	Dry, dark and at 0 - 4 °C
Long-term Storage Conditions	-20 °C
BoilingPoint	1187.3±65.0 °C at 760 mmHg
ShelfLife	>2 years if stored properly
Melting Point	N/A