Rotigaptide, also called ZP-123, is a peptide analog, which has been shown to increase gap junction intercellular conductance in cardiac muscle cells. Gap junctions are protein channels that are responsible for conducting electrical impulses between cells in the heart to maintain normal rhythm.
CAT No: 10-101-55
CAS No: 355151-12-1
Synonyms/Alias: Rotigaptide;355151-12-1;ZP-123;ZP-123 (ZEALAND);GAP (WYETH);UNII-GFA1W6KO7N;GFA1W6KO7N;Rotigaptide [USAN:INN];Rotigaptide [USAN];rotigaptida;GAP 484;GAP 486;ZP123;ZP 123;Rotigaptide (USAN);ROTIGAPTIDE [INN];(2R,4S)-1-[(2R)-1-[(2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]-N-[2-[[(2R)-1-[(2-amino-2-oxoethyl)amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]-4-hydroxypyrrolidine-2-carboxamide;Ac-d-Tyr-d-Pro-d-Hyp-Gly-d-Ala-Gly-NH2;Glycinamide, N-acetyl-D-tyrosyl-D-prolyl-(4S)-4-hydroxy-D-prolylglycyl-D-alanyl-;Dipeptide 9f [PMID 19175320];Dipeptide 9f (PMID 19175320);CHEMBL450656;rotigaptidum;GAP-486;(2R)-N-(carbamoylmethyl)-2-(2-(((2R,4S)-1-((2R)-1-((2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl)pyrrolidine-2-carbonyl)-4-hydroxypyrrolidin-2-yl)formamido)acetamido)propanamide;(2R)-N-(carbamoylmethyl)-2-(2-{[(2R,4S)-1-[(2R)-1-[(2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidin-2-yl]formamido}acetamido)propanamide;(2R,4S)-1-((2R)-1-((2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl)pyrrolidine-2-carbonyl)-N-(2-(((2R)-1-((2-amino-2-oxoethyl)amino)-1-oxopropan-2-yl)amino)-2-oxoethyl)-4-hydroxypyrrolidine-2-carboxamide;ZP123 peptide;zp1-23;GTPL9214;DTXCID10111515;CHEBI:230093;Ac-Tyr-Pro-Hyp-Gly-Ala-Gly-NH2;AKOS040742576;DB13067;DA-67291;MS-30756;HY-106225;CS-0025346;NS00071051;D05767;G17110;Q7370547;acetyl-tyrosyl-prolyl-hydroxyprolyl-glycyl-alanyl-glycinamide;N-Acetyl-d-tyrosyl-d-prolyl-(4S)-4-hydroxy-d-prolylglycyl-d-alanylglycinamide;
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M.F/Formula | C28H39N7O9 |
M.W/Mr. | 617.7 |
Sequence | One Letter Code:YPXGAG Three Letter Code:Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2 |
Labeling Target | Gap junction modulator |
Application | Rotigaptide is currently under clinical investigation for the treatment of cardiac arrhythmias–specifically atrial fibrillation. |
Appearance | Solid powder |
Purity | >98% (or refer to the Certificate of Analysis) |
Biological Activity | Rotigaptide, also known as GAP-486; ZP-123, is a gap junction modulator potentially for the treatment of ventricular tachycardia and atrial. |
Areas of Interest | Cardiovascular System & Diseases Pituitary & Hypothalamic Hormones |
Long-term Storage Conditions | Soluble in DMSO |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Short-term Storage Conditions | Dry, dark and at 0 - 4 °C |
Solubility | -20 °C |
InChI | InChI=1S/C28H39N7O9/c1-15(25(41)30-12-23(29)39)32-24(40)13-31-26(42)22-11-19(38)14-35(22)28(44)21-4-3-9-34(21)27(43)20(33-16(2)36)10-17-5-7-18(37)8-6-17/h5-8,15,19-22,37-38H,3-4,9-14H2,1-2H3,(H2,29,39)(H,30,41)(H,31,42)(H,32,40)(H,33,36)/t15-,19+,20-,21-,22-/m1/s1 |
InChI Key | GFJRASPBQLDRRY-TWTQBQJDSA-N |
BoilingPoint | 1187.3±65.0 °C at 760 mmHg |
ShelfLife | >2 years if stored properly |
Melting Point | N/A |
1. The spatiotemporal control of signalling and trafficking of the GLP-1R
2. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
3. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
4. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die
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