Rotigaptide

Rotigaptide, also called ZP-123, is a peptide analog, which has been shown to increase gap junction intercellular conductance in cardiac muscle cells. Gap junctions are protein channels that are responsible for conducting electrical impulses between cells in the heart to maintain normal rhythm.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Rotigaptide(CAS 355151-12-1)

CAT No: 10-101-55

CAS No:355151-12-1

Synonyms/Alias:Rotigaptide;355151-12-1;ZP-123;ZP-123 (ZEALAND);GAP (WYETH);UNII-GFA1W6KO7N;GFA1W6KO7N;Rotigaptide [USAN:INN];Rotigaptide [USAN];rotigaptida;GAP 484;GAP 486;ZP123;ZP 123;Rotigaptide (USAN);ROTIGAPTIDE [INN];(2R,4S)-1-[(2R)-1-[(2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]-N-[2-[[(2R)-1-[(2-amino-2-oxoethyl)amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]-4-hydroxypyrrolidine-2-carboxamide;Ac-d-Tyr-d-Pro-d-Hyp-Gly-d-Ala-Gly-NH2;Glycinamide, N-acetyl-D-tyrosyl-D-prolyl-(4S)-4-hydroxy-D-prolylglycyl-D-alanyl-;Dipeptide 9f [PMID 19175320];Dipeptide 9f (PMID 19175320);CHEMBL450656;rotigaptidum;GAP-486;(2R)-N-(carbamoylmethyl)-2-(2-(((2R,4S)-1-((2R)-1-((2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl)pyrrolidine-2-carbonyl)-4-hydroxypyrrolidin-2-yl)formamido)acetamido)propanamide;(2R)-N-(carbamoylmethyl)-2-(2-{[(2R,4S)-1-[(2R)-1-[(2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidin-2-yl]formamido}acetamido)propanamide;(2R,4S)-1-((2R)-1-((2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl)pyrrolidine-2-carbonyl)-N-(2-(((2R)-1-((2-amino-2-oxoethyl)amino)-1-oxopropan-2-yl)amino)-2-oxoethyl)-4-hydroxypyrrolidine-2-carboxamide;ZP123 peptide;zp1-23;GTPL9214;DTXCID10111515;CHEBI:230093;Ac-Tyr-Pro-Hyp-Gly-Ala-Gly-NH2;AKOS040742576;DB13067;DA-67291;MS-30756;HY-106225;CS-0025346;NS00071051;D05767;G17110;Q7370547;acetyl-tyrosyl-prolyl-hydroxyprolyl-glycyl-alanyl-glycinamide;N-Acetyl-d-tyrosyl-d-prolyl-(4S)-4-hydroxy-d-prolylglycyl-d-alanylglycinamide;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C28H39N7O9
M.W/Mr.
617.7
Sequence
One Letter Code:YPXGAG
Three Letter Code:Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2
Labeling Target
Gap junction modulator
Application
Rotigaptide is currently under clinical investigation for the treatment of cardiac arrhythmias–specifically atrial fibrillation.
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Biological Activity
Rotigaptide, also known as GAP-486; ZP-123, is a gap junction modulator potentially for the treatment of ventricular tachycardia and atrial.
Areas of Interest
Cardiovascular System & Diseases
Pituitary & Hypothalamic Hormones
Long-term Storage Conditions
Soluble in DMSO
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions
Dry, dark and at 0 - 4 °C
Solubility
-20 °C
InChI
InChI=1S/C28H39N7O9/c1-15(25(41)30-12-23(29)39)32-24(40)13-31-26(42)22-11-19(38)14-35(22)28(44)21-4-3-9-34(21)27(43)20(33-16(2)36)10-17-5-7-18(37)8-6-17/h5-8,15,19-22,37-38H,3-4,9-14H2,1-2H3,(H2,29,39)(H,30,41)(H,31,42)(H,32,40)(H,33,36)/t15-,19+,20-,21-,22-/m1/s1
InChI Key
GFJRASPBQLDRRY-TWTQBQJDSA-N
BoilingPoint
1187.3±65.0 °C at 760 mmHg
ShelfLife
>2 years if stored properly
Melting Point
N/A

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