Spinorphin

Name: Spinorphin
Brand: Creative Peptides
SKU: R1871
Availability: MadeToOrder

Spinorphin is an endogenous opioid heptapeptide that exhibits inhibitory effects on enkephalin-degrading enzymes. The mechanism of action of spinophin has not been fully elucidated but it has been found to act as an antagonist of the P2X3 receptor, and as a weak partial agonist/antagonist of the FP1 receptor.

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CAT No: R1871

CAS No: 137201-62-8

Synonyms/Alias: Spinorphin;137201-62-8;LVVYPWT;Leu-val-val-tyr-pro-trp-thr;(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoic acid;Leucyl-valyl-valyl-tyrosyl-prolyl-tryptophyl-threonine;L-Threonine, L-leucyl-L-valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-;L-Threonine, N-(N-(1-(N-(N-(N-L-leucyl-L-valyl)-L-valyl)-L-tyrosyl)-L-prolyl)-L-tryptophyl)-;CHEMBL395493;DTXSID70160105;LVV-hemorphin-4;L-leucyl-L-valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-L-threonine;(2S,3R)-2-(((2S)-2-(((2S)-1-((2S)-2-(((2S)-2-(((2S)-2-(((2S)-2-amino-4-methylpentanoyl)amino)-3-methylbutanoyl)amino)-3-methylbutanoyl)amino)-3-(4-hydroxyphenyl)propanoyl)pyrrolidine-2-carbonyl)amino)-3-(1H-indol-3-yl)propanoyl)amino)-3-hydroxybutanoic acid;GTPL1026;leucyl--valyl-valyl-tyrosyl-prolyl-tryptophyl-threonine;DTXCID3082596;SCHEMBL25217672;CHEBI:172845;HY-P1044;BDBM50219120;AKOS024457342;AC-33668;TS-09808;DB-230577;CS-0025001;Q7577645;

Chemical Name: (2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoic acid

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Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C45H64N8O10
M.W/Mr.	877
Sequence	One Letter Code:LVVYPWT Three Letter Code:H-Leu-Val-Val-Tyr-Pro-Trp-Thr-OH
Appearance	White lyophilised solid

Shipping Condition	Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
InChI	InChI=1S/C45H64N8O10/c1-23(2)19-31(46)39(56)50-37(25(5)6)43(60)51-36(24(3)4)42(59)49-34(20-27-14-16-29(55)17-15-27)44(61)53-18-10-13-35(53)41(58)48-33(40(57)52-38(26(7)54)45(62)63)21-28-22-47-32-12-9-8-11-30(28)32/h8-9,11-12,14-17,22-26,31,33-38,47,54-55H,10,13,18-21,46H2,1-7H3,(H,48,58)(H,49,59)(H,50,56)(H,51,60)(H,52,57)(H,62,63)/t26-,31+,33+,34+,35+,36+,37+,38+/m1/s1
InChI Key	BXIFNVGZIMFBQB-DYDSHOKNSA-N
Canonical SMILES	CC(C)CC(C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N2CCCC2C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(C(C)O)C(=O)O)N
Isomeric SMILES	C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N)O

1. A possible role of tachykinin-related peptide on an immune system activity of mealworm beetle, Tenebrio molitor L

2. The spatiotemporal control of signalling and trafficking of the GLP-1R

3. Effect of Short-Term Desiccation, Recovery Time, and CAPA-PVK Neuropeptide on the Immune System of the Burying Beetle Nicrophorus vespilloides

4. Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L

5. An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I

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