Tetracosactide Acetate

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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CAT No: 10-101-01

CAS No: 16960-16-0

Synonyms/Alias: Tetracosactide;COSYNTROPIN;16960-16-0;Tetracosactida;Tetracosactrin;VICOTROPE;Cortrosyn;Tetracosapeptide;CHEBI:3901;CORTICOTROPIN TETRACOSAPEPTIDE;Tetracosactide acetate;Cortrosinta;Tetracosactid;Actholain;ACTH(1-24);Cosyntropin acetate;Synthetic ACTH;1-24-Corticotropin;Corticotropin S;Corticotropin (1-24)-Peptide;1-24-ACTH;tetracosactrin zinc;Corticotropin (1-24)-Tetracosapeptide;Tetracosactide hexacetate;alpha(1-24)-ACTH;beta(1-24)-ACTH;tetracosactide for bioassay;beta(1-24)-Corticotropin;alpha(1-24)-Corticotropin;SCHEMBL33366;TETRACOSACTIDE (MART.);CHEMBL2103784;H01AA02;DTXCID501437057;COSYNTROPIN (USP MONOGRAPH);EX-A8105;BDBM50017180;TETRACOSACTIDE (EP MONOGRAPH);AKOS015994630;Tetracosactide Acetate (ACTH 1-24);AC-8933;HS-2001;Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro;241-031-1;

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M.F/FormulaC136H210N40O31S
M.W/Mr.2933.4
SequenceOne Letter Code:SYSMEHFRWGKPVGKKRRPVKVYP
Three Letter Code:H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
ApplicationTetracosactide is used for diagnostic purposes. It is suitable for treatment of adrenal insufficiency of central origin. It can also be used to diagnose Addison's disease.
ActivityAgonist
TargetAdrenocorticotropic hormone receptor
Long-term Storage ConditionsH2O : 100 mg/mL (34.09 mM; Need ultrasonic)
Shipping ConditionRoom temperature in continental US; may vary elsewhere.
InChIInChI=1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-/m0/s1
InChI KeyZOEFCCMDUURGSE-SQKVDDBVSA-N
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