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Tetracosactide Acetate

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Tetracosactide Acetate(CAS 16960-16-0)

CAT No: 10-101-01

CAS No:16960-16-0

Synonyms/Alias:Tetracosactide;COSYNTROPIN;16960-16-0;Tetracosactida;Tetracosactrin;VICOTROPE;Cortrosyn;Tetracosapeptide;CHEBI:3901;CORTICOTROPIN TETRACOSAPEPTIDE;Tetracosactide acetate;Cortrosinta;Tetracosactid;Actholain;ACTH(1-24);Cosyntropin acetate;Synthetic ACTH;1-24-Corticotropin;Corticotropin S;Corticotropin (1-24)-Peptide;1-24-ACTH;tetracosactrin zinc;Corticotropin (1-24)-Tetracosapeptide;Tetracosactide hexacetate;alpha(1-24)-ACTH;beta(1-24)-ACTH;tetracosactide for bioassay;beta(1-24)-Corticotropin;alpha(1-24)-Corticotropin;SCHEMBL33366;TETRACOSACTIDE (MART.);CHEMBL2103784;H01AA02;DTXCID501437057;COSYNTROPIN (USP MONOGRAPH);EX-A8105;BDBM50017180;TETRACOSACTIDE (EP MONOGRAPH);AKOS015994630;Tetracosactide Acetate (ACTH 1-24);AC-8933;HS-2001;Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro;241-031-1;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C136H210N40O31S
M.W/Mr.
2933.4
Sequence
One Letter Code:SYSMEHFRWGKPVGKKRRPVKVYP
Three Letter Code:H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
Application
Tetracosactide is used for diagnostic purposes. It is suitable for treatment of adrenal insufficiency of central origin. It can also be used to diagnose Addison's disease.
Activity
Agonist
Target
Adrenocorticotropic hormone receptor
Long-term Storage Conditions
H2O : 100 mg/mL (34.09 mM; Need ultrasonic)
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-/m0/s1
InChI Key
ZOEFCCMDUURGSE-SQKVDDBVSA-N

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