Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.
CAT No: 10-101-01
CAS No:16960-16-0
Synonyms/Alias:Tetracosactide;COSYNTROPIN;16960-16-0;Tetracosactida;Tetracosactrin;VICOTROPE;Cortrosyn;Tetracosapeptide;CHEBI:3901;CORTICOTROPIN TETRACOSAPEPTIDE;Tetracosactide acetate;Cortrosinta;Tetracosactid;Actholain;ACTH(1-24);Cosyntropin acetate;Synthetic ACTH;1-24-Corticotropin;Corticotropin S;Corticotropin (1-24)-Peptide;1-24-ACTH;tetracosactrin zinc;Corticotropin (1-24)-Tetracosapeptide;Tetracosactide hexacetate;alpha(1-24)-ACTH;beta(1-24)-ACTH;tetracosactide for bioassay;beta(1-24)-Corticotropin;alpha(1-24)-Corticotropin;SCHEMBL33366;TETRACOSACTIDE (MART.);CHEMBL2103784;H01AA02;DTXCID501437057;COSYNTROPIN (USP MONOGRAPH);EX-A8105;BDBM50017180;TETRACOSACTIDE (EP MONOGRAPH);AKOS015994630;Tetracosactide Acetate (ACTH 1-24);AC-8933;HS-2001;Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro;241-031-1;
Tetracosactide Acetate is a synthetic peptide analog corresponding to the first 24 amino acids of adrenocorticotropic hormone (ACTH). As a chemically defined peptide, it mimics the biologically active N-terminal fragment of endogenous ACTH, a key regulator of adrenal cortex function and steroidogenesis. Owing to its stable structure and preserved bioactivity, this compound serves as a valuable tool in biochemical research focused on endocrine signaling, peptide-receptor interactions, and the molecular mechanisms underlying adrenal physiology. Its defined sequence and robust activity profile make it particularly relevant for studies requiring precise modulation of ACTH pathways, as well as for peptide synthesis and functional assays in the context of peptide hormone research.
Endocrine signaling research: Tetracosactide Acetate is widely utilized in investigations of the hypothalamic-pituitary-adrenal (HPA) axis, providing a controlled means to stimulate adrenal steroidogenesis in vitro and in vivo models. By binding to melanocortin 2 receptors (MC2R) on adrenocortical cells, it enables researchers to dissect the downstream biochemical cascades involved in cortisol and aldosterone synthesis. This application is particularly important for elucidating the regulatory dynamics of stress response pathways and for characterizing the molecular determinants of ACTH receptor activation.
Peptide-receptor interaction studies: The defined sequence of Tetracosactide Acetate makes it an ideal ligand for probing the structure-function relationships of ACTH receptors. Researchers employ this peptide to assess binding affinities, receptor activation thresholds, and signal transduction mechanisms in diverse cellular systems. Such studies contribute to a deeper understanding of G protein-coupled receptor (GPCR) pharmacology and facilitate the identification of critical residues involved in ligand recognition and receptor specificity.
Peptide synthesis and analytical method development: As a reference standard, Tetracosactide Acetate supports the validation and optimization of peptide synthesis protocols, including solid-phase peptide synthesis (SPPS) and chromatographic purification techniques. Its well-characterized properties allow for the calibration of analytical methods such as high-performance liquid chromatography (HPLC) and mass spectrometry, ensuring accurate quantification and structural verification of synthetic peptides. This role is essential for quality control and the development of robust workflows in peptide chemistry laboratories.
Cell signaling pathway elucidation: The ability of Tetracosactide Acetate to selectively activate ACTH-dependent signaling cascades makes it an indispensable tool for mapping intracellular events following receptor engagement. Scientists use it to trigger cyclic AMP (cAMP) production, protein kinase A (PKA) activation, and downstream transcriptional responses in adrenocortical and heterologous expression systems. These studies advance knowledge of second messenger systems and the integration of extracellular peptide signals with cellular gene expression programs.
Comparative peptide pharmacology: The synthetic nature and defined activity profile of Tetracosactide Acetate enable its use in comparative studies alongside native ACTH and related melanocortin peptides. Researchers leverage this compound to delineate the contributions of specific peptide fragments to receptor selectivity, potency, and efficacy. Such comparative analyses inform the rational design of novel peptide analogs and support the development of selective modulators for basic research and potential industrial applications.
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5. The spatiotemporal control of signalling and trafficking of the GLP-1R
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