Tetracosactide Acetate

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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CAT No: 10-101-01

CAS No: 16960-16-0

Synonyms/Alias: Tetracosactide;COSYNTROPIN;16960-16-0;Tetracosactida;Tetracosactrin;VICOTROPE;Cortrosyn;Tetracosapeptide;CHEBI:3901;CORTICOTROPIN TETRACOSAPEPTIDE;Tetracosactide acetate;Cortrosinta;Tetracosactid;Actholain;ACTH(1-24);Cosyntropin acetate;Synthetic ACTH;1-24-Corticotropin;Corticotropin S;Corticotropin (1-24)-Peptide;1-24-ACTH;tetracosactrin zinc;Corticotropin (1-24)-Tetracosapeptide;Tetracosactide hexacetate;alpha(1-24)-ACTH;beta(1-24)-ACTH;tetracosactide for bioassay;beta(1-24)-Corticotropin;alpha(1-24)-Corticotropin;SCHEMBL33366;TETRACOSACTIDE (MART.);CHEMBL2103784;H01AA02;DTXCID501437057;COSYNTROPIN (USP MONOGRAPH);EX-A8105;BDBM50017180;TETRACOSACTIDE (EP MONOGRAPH);AKOS015994630;Tetracosactide Acetate (ACTH 1-24);AC-8933;HS-2001;Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro;241-031-1;

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Specification Technical Data Publications Customer reviews and Q&A
M.F/FormulaC136H210N40O31S
M.W/Mr.2933.4
SequenceOne Letter Code:SYSMEHFRWGKPVGKKRRPVKVYP
Three Letter Code:H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
ApplicationTetracosactide is used for diagnostic purposes. It is suitable for treatment of adrenal insufficiency of central origin. It can also be used to diagnose Addison's disease.
ActivityAgonist
TargetAdrenocorticotropic hormone receptor
Long-term Storage ConditionsH2O : 100 mg/mL (34.09 mM; Need ultrasonic)
Shipping ConditionRoom temperature in continental US; may vary elsewhere.
InChIInChI=1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-/m0/s1
InChI KeyZOEFCCMDUURGSE-SQKVDDBVSA-N

1. Proinsulin C-peptide and insulin: Limited pattern similarities of interest in inter-peptide interactions but no C-peptide effect on insulin and IGF-1 receptor signaling

2. Implications of ligand-receptor binding kinetics on GLP-1R signalling

3. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die

4. cRGD-functionalized, DOX-conjugated, and 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging

5. Crystal Structure of BamB from Pseudomonas aeruginosa and Functional Evaluation of Its Conserved Structural Features

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