Xipamide acts on the kidneys to reduce sodium reabsorption in the distal convoluted tubule. This increases the osmolarity in the lumen, causing less water to be reabsorbed by the collecting ducts. Additionally, it increases the secretion of potassium in the distal tubule and collecting ducts.
Registration of APIs CMC information required for an IND
IND and NDA support Drug master files (DMF) filing
Synonyms/Alias | Be-1293; MJF 10938; 5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-benzamide; 4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoyl-benzamide; 4-Chloro-5-sulfamoyl-2',6'-salicyloxylidide |
M.F/Formula | C15H15ClN2O4S |
M.W/Mr. | 354.8 |
Labeling Target | Carbonic anyydrase (CA) |
Application | Xipamide (marketed under the tradename Aquaphor and Aquaphoril) is a sulfonamide diuretic drug. It is used for the treatment of oedema and hypertension. |
Appearance | Solid powder |
Purity | >98% (or refer to the Certificate of Analysis) |
Activity | Agonist |
Biological Activity | Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE). |
Areas of Interest | Hypertension & Edema |
Functions | Toxic substance binding |
Source# | Synthetic |
Long-term Storage Conditions | Soluble in DMSO. |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Short-term Storage Conditions | Dry, dark and at 0 - 4 °C |
Solubility | -20 °C |
Organism | Human |
InChI | InChI=1S/C15H15ClN2O4S/c1-8-4-3-5-9(2)14(8)18-15(20)10-6-13(23(17,21)22)11(16)7-12(10)19/h3-7,19H,1-2H3,(H,18,20)(H2,17,21,22) |
InChI Key | MTZBBNMLMNBNJL-UHFFFAOYSA-N |
BoilingPoint | N/A |
ShelfLife | >2 years if stored properly |
Melting Point | 255-256ºC |
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us. We will endeavor to provide highly satisfying products and services.