Xipamide

Xipamide acts on the kidneys to reduce sodium reabsorption in the distal convoluted tubule. This increases the osmolarity in the lumen, causing less water to be reabsorbed by the collecting ducts. Additionally, it increases the secretion of potassium in the distal tubule and collecting ducts.

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CAT No: 10-101-127

CAS No: 14293-44-8

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Synonyms/AliasBe-1293; MJF 10938; 5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-benzamide; 4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoyl-benzamide; 4-Chloro-5-sulfamoyl-2',6'-salicyloxylidide
M.F/FormulaC15H15ClN2O4S
M.W/Mr.354.8
Labeling TargetCarbonic anyydrase (CA)
ApplicationXipamide (marketed under the tradename Aquaphor and Aquaphoril) is a sulfonamide diuretic drug. It is used for the treatment of oedema and hypertension.
AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
ActivityAgonist
Biological ActivityXipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE).
Areas of InterestHypertension & Edema
FunctionsToxic substance binding
Source#Synthetic
Long-term Storage ConditionsSoluble in DMSO.
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage ConditionsDry, dark and at 0 - 4 °C
Solubility-20 °C
OrganismHuman
InChIInChI=1S/C15H15ClN2O4S/c1-8-4-3-5-9(2)14(8)18-15(20)10-6-13(23(17,21)22)11(16)7-12(10)19/h3-7,19H,1-2H3,(H,18,20)(H2,17,21,22)
InChI KeyMTZBBNMLMNBNJL-UHFFFAOYSA-N
BoilingPointN/A
ShelfLife>2 years if stored properly
Melting Point255-256ºC
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