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Xipamide

Xipamide acts on the kidneys to reduce sodium reabsorption in the distal convoluted tubule. This increases the osmolarity in the lumen, causing less water to be reabsorbed by the collecting ducts. Additionally, it increases the secretion of potassium in the distal tubule and collecting ducts.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: 10-101-127

CAS No:14293-44-8

Synonyms/Alias:Be-1293; MJF 10938; 5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-benzamide; 4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoyl-benzamide; 4-Chloro-5-sulfamoyl-2',6'-salicyloxylidide

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cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
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  • Drug master files (DMF) filing
M.F/Formula
C15H15ClN2O4S
M.W/Mr.
354.8
Labeling Target
Carbonic anyydrase (CA)
Application
Xipamide (marketed under the tradename Aquaphor and Aquaphoril) is a sulfonamide diuretic drug. It is used for the treatment of oedema and hypertension.
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Activity
Agonist
Biological Activity
Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE).
Areas of Interest
Hypertension & Edema
Functions
Toxic substance binding
Source#
Synthetic
Long-term Storage Conditions
Soluble in DMSO.
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions
Dry, dark and at 0 - 4 °C
Solubility
-20 °C
Organism
Human
InChI
InChI=1S/C15H15ClN2O4S/c1-8-4-3-5-9(2)14(8)18-15(20)10-6-13(23(17,21)22)11(16)7-12(10)19/h3-7,19H,1-2H3,(H,18,20)(H2,17,21,22)
InChI Key
MTZBBNMLMNBNJL-UHFFFAOYSA-N
BoilingPoint
N/A
ShelfLife
>2 years if stored properly
Melting Point
255-256ºC

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