Xipamide
Xipamide acts on the kidneys to reduce sodium reabsorption in the distal convoluted tubule. This increases the osmolarity in the lumen, causing less water to be reabsorbed by the collecting ducts. Additionally, it increases the secretion of potassium in the distal tubule and collecting ducts.
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| CAT# | 10-101-127 |
| CAS | 14293-44-8 |
| Background | Like the structurally related thiazide diuretics, xipamide acts on the kidneys to reduce sodium reabsorption in the distal convoluted tubule. This increases the osmolarity in the lumen, causing less water to be reabsorbed by the collecting ducts. This leads to increased urinary output. Unlike the thiazides, xipamide reaches its target from the peritubular side (blood side). |
| Synonyms/Alias | Be-1293; MJF 10938; 5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-benzamide; 4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoyl-benzamide; 4-Chloro-5-sulfamoyl-2',6'-salicyloxylidide |
| M.F/Formula | C15H15ClN2O4S |
| M.W/Mr. | 354.8 |
| Labeling Target | Carbonic anyydrase (CA) |
| Application | Xipamide (marketed under the tradename Aquaphor and Aquaphoril) is a sulfonamide diuretic drug. It is used for the treatment of oedema and hypertension. |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Activity | Agonist |
| Biological Activity | Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE). |
| Areas of Interest | Hypertension & Edema |
| Functions | Toxic substance binding |
| Source# | Synthetic |
Solubility | Soluble in DMSO. |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Short-term Storage Conditions | Dry, dark and at 0 - 4 °C |
Long-term Storage Conditions | -20 °C |
Organism | Human |
InChI | InChI=1S/C15H15ClN2O4S/c1-8-4-3-5-9(2)14(8)18-15(20)10-6-13(23(17,21)22)11(16)7-12(10)19/h3-7,19H,1-2H3,(H,18,20)(H2,17,21,22) |
InChI Key | MTZBBNMLMNBNJL-UHFFFAOYSA-N |
BoilingPoint | N/A |
ShelfLife | >2 years if stored properly |
Melting Point | 255-256ºC |
| CAT# |
Product Name |
M.W |
Molecular Formula |
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| 10-101-125 |
Trandolapril |
430.53 |
C24H34N2O5 |
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