Bremelanotide

Bremelanotide, formerly known as PT-141, is a peptide drug. Bremelanotide acts as a non-selective agonist of all of the melanocortin receptors except MC2.

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Bremelanotide(CAS 189691-06-3)

CAT No: 10-101-112

CAS No: 189691-06-3

Synonyms/Alias: Bremelanotide;189691-06-3;PT-141;UNII-6Y24O4F92S;Bremelanotida;6Y24O4F92S;Bremelanotide [USAN:INN];PT-141 FREE BASE;PT 141;(3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxylic acid;DTXSID40893711;PT141;Vyleesi (TN);L-Lysine, N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, (2->7)-lactam;N-Acetyl-L-2-aminohexanoyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysine-(2->7)-lactam;(3S,6S,9R,12S,15S,23S)-12-((1H-imidazol-5-yl)methyl)-3-((1H-indol-3-yl)methyl)-15-((S)-2-acetamidohexanamido)-9-benzyl-6-(3-guanidinopropyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxylic acid;Bremelanotidum;Bremelanotide?;Bremelanotide PT 141;Bremelanotide, PT-141;N-Acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysine (2-7)-lactam;PT141;BREMELANOTIDE [MI];BREMELANOTIDE [INN];PT-141 (Bremelanotide);Bremelanotide (USAN/INN);BREMELANOTIDE [USAN];BREMELANOTIDE [WHO-DD];CHEMBL2070241;SCHEMBL13574795;SCHEMBL20337333;GTPL10408;CHEBI:177849;DTXCID701323799;189691-06-3 (free base);BDBM50389769;AKOS005145807;AT41880;DB11653;HS-2024;DA-61875;FB159119;HY-18678;CS-0013839;D06569;Q415353;BRD-K06328344-015-01-7;L-LYSINE, N-ACETYL-L-NORLEUCYL-L-.ALPHA.-ASPARTYL-L-HISTIDYL-D-PHENYLALANYL-L-ARGINYL-L-TRYPTOPHYL-, (2->7)-LACTAM;N-ACETYL-L-2-AMINOHEXANOYL-L-.ALPHA.-ASPARTYL-L-HISTIDYL-D-PHENYLALANYL-L-ARGINYL-L-TRYPTOPHYL-L-LYSINE-(2->7)-LACTAM;

Chemical Name: (3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxylic acid

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Specification Technical Data Publications Customer reviews and Q&A
M.F/FormulaC50H68N14O10
M.W/Mr.1025.2
SequenceOne Letter Code:XDHFRWK
Three Letter Code:Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-OH
ApplicationErectile dysfunction & Female sexual dysfunction & Hemorrhagic shock & Reperfusion injury
AppearanceWhite Powder
ActivityAgonist
TargetMelanocortin Receptor
Length7
Shipping ConditionRoom temperature in continental US; may vary elsewhere.
InChIInChI=1S/C50H68N14O10/c1-3-4-16-35(58-29(2)65)43(67)64-41-25-42(66)54-20-11-10-18-37(49(73)74)60-46(70)39(23-31-26-56-34-17-9-8-15-33(31)34)62-44(68)36(19-12-21-55-50(51)52)59-45(69)38(22-30-13-6-5-7-14-30)61-47(71)40(63-48(41)72)24-32-27-53-28-57-32/h5-9,13-15,17,26-28,35-41,56H,3-4,10-12,16,18-25H2,1-2H3,(H,53,57)(H,54,66)(H,58,65)(H,59,69)(H,60,70)(H,61,71)(H,62,68)(H,63,72)(H,64,67)(H,73,74)(H4,51,52,55)/t35-,36-,37-,38+,39-,40-,41-/m0/s1
InChI KeyFFHBJDQSGDNCIV-MFVUMRCOSA-N
Canonical SMILESCCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)O)NC(=O)C
Isomeric SMILESCCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)O)NC(=O)C

1. Glucagonlike peptide 2 analogue teduglutide: stimulation of proliferation but reduction of differentiation in human Caco-2 intestinal epithelial cells

2. Myotropic activity of allatostatins in tenebrionid beetles

3. A possible role of tachykinin-related peptide on an immune system activity of mealworm beetle, Tenebrio molitor L

4. Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

5. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function

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