ω-Conotoxin MVIIC

Like ω-conotoxin GVIA, this Conus magus peptide inhibits presynaptic Ca²⁺ channels. However, ω-conotoxin MVIIC clearly inhibits additional Ca²⁺ channel subtypes in the mammalian central nervous system. Thus, it should become a standard pharmacological reagent for investigating synaptic transmission in the mammalian nervous system.

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CAT#C27002
CAS147794-23-8
Synonyms/Aliasomega-conotoxin MVIIC; omega-Ctx-mviic
Chemical Name2-[(1R,4S,7S,10S,13S,16S,19S,22R,27R,30S,36S,39S,45R,48S,54S,57R,62R,65S,71S,77S,83S)-62-amino-7,30,65,71-tetrakis(4-aminobutyl)-4,36,39-tris(3-carbamimidamidopropyl)-27-carbamoyl-10-[(1R)-1-hydroxyethyl]-48,54-bis(hydroxymethyl)-16-[(4-hydroxyphenyl)methyl]-77-methyl-13-(2-methylsulfanylethyl)-2,5,8,11,14,17,20,29,32,35,38,41,44,47,50,53,56,63,66,69,72,75,78,84,91-pentacosaoxo-24,25,59,60,87,88-hexathia-3,6,9,12,15,18,21,28,31,34,37,40,43,46,49,52,55,64,67,70,73,76,79,85,90-pentacosazatetracyclo[43.40.4.222,57.079,83]hennonacontan-19-yl]acetic acid
M.F/FormulaC106H178N40O32S7
M.W/Mr.2749.3
SequenceOne Letter Code: CKGKGAPCRKTMYDCCSGSCGRRGKC
Three Letter Code: H-Cys(1)-Lys-Gly-Lys-Gly-Ala-Pro-Cys(2)-Arg-Lys-Thr-Met-Tyr-Asp-Cys(3)-Cys(1)-Ser-Gly-Ser-Cys(2)-Gly-Arg-Arg-Gly-Lys-Cys(3)-NH2
ActivityInhibitor
Biological ActivityPeptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.
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