Hepcidin-25 (human) is a peptide hormone commonly used in the biomedical industry to regulate iron metabolism. It plays a significant role in the treatment of iron-related disorders such as anemia and hemochromatosis. This product helps control iron absorption and release from cells, maintaining overall iron homeostasis in the body.
CAT No: R2027
CAS No:1356390-47-0
Synonyms/Alias:Hepcidin;Hepcidin-25 (human);1356390-47-0;UNII-XUH21YGS7O;Hepcidin [USAN];hepcidin-25;XUH21YGS7O;WHO 11354;Asp-thr-his-phe-pro-ile-cys-ile-phe-cys-cys-gly-cys-cys-his-arg-ser-lys-cys-gly-met-cys-cys-lys-thr (7->23),(10->13),(11->19),(14->22)-tetrakis(disulfide);Hepcidin-25 (human) trifluoroacetate salt;FH109655;LEAP-1 (human), Hepc25 (human), Liver-Expressed Antimicrobial Peptide (human), PLTR (human), Putative Liver Tumor Regressor (human);
Chemical Name:(3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
Hepcidin-25 (human) is a synthetic peptide that represents the biologically active, 25-amino acid form of the human hepcidin hormone. As a key regulator of systemic iron homeostasis, this peptide modulates iron absorption and distribution by binding to the iron exporter ferroportin, leading to its internalization and degradation. The resulting decrease in iron efflux from enterocytes, hepatocytes, and macrophages plays a central role in the maintenance of iron balance in the body. Due to its pivotal function in iron metabolism, Hepcidin-25 is of significant interest in biochemical research, particularly in studies investigating iron-related disorders, regulatory pathways, and the molecular mechanisms underlying iron transport.
Iron Metabolism Research: Hepcidin-25 is widely utilized in studies focused on elucidating the molecular mechanisms governing iron homeostasis. Researchers employ this peptide to investigate regulatory feedback loops between hepcidin expression and systemic iron levels, as well as to model the peptide's impact on cellular iron export via ferroportin. These studies contribute to a deeper understanding of iron overload and deficiency conditions, enabling the dissection of pathways responsible for iron absorption, recycling, and storage.
Disease Mechanism Elucidation: The peptide serves as a valuable tool in the exploration of pathophysiological processes associated with iron dysregulation, such as hereditary hemochromatosis, anemia of inflammation, and chronic kidney disease. By modulating hepcidin signaling in cell-based and animal models, scientists can delineate the consequences of altered hepcidin activity on tissue iron distribution and identify molecular targets implicated in disease progression. Such research supports the identification of novel biomarkers and therapeutic strategies in iron-related disorders.
Peptide-Protein Interaction Studies: Hepcidin-25 is frequently employed in binding assays and structural analyses to characterize its interaction with ferroportin and other iron-transport proteins. These investigations provide insights into the structural determinants of peptide-receptor specificity, affinity, and downstream signaling events. Understanding these interactions at the molecular level is crucial for advancing knowledge of iron trafficking and for guiding the design of peptide analogs or inhibitors with tailored biological activities.
Analytical Standards Development: In the context of bioanalytical research, synthetic Hepcidin-25 is used as a reference standard for the quantification of endogenous hepcidin levels in biological samples. Its well-defined sequence and physicochemical properties make it suitable for use in mass spectrometry-based assays, immunoassays, and other quantitative techniques. Accurate measurement of hepcidin concentrations is essential for clinical research and for the validation of diagnostic assays aimed at evaluating iron status and related metabolic conditions.
Peptide Stability and Pharmacokinetics: The synthetic form of the peptide is also instrumental in studies evaluating peptide stability, degradation pathways, and pharmacokinetic properties. By subjecting Hepcidin-25 to various physiological and experimental conditions, researchers can assess its susceptibility to proteolytic enzymes, characterize degradation products, and model its distribution and clearance in biological systems. These data are valuable for the development of more stable analogs and for optimizing experimental protocols in peptide-based research.
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