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Splenopentin Acetate

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SP-5; splenin pentapeptide (32-36); splenin pentapeptide(32-36); splenin pentapeptide 32-36; splenin pentapeptide32-36; thymopoietin III pentapeptide (32-36); thymopoietin III pentapeptide(32-36); thymopoietin III pentapeptide 32-36; thymopoietin III pentapeptide32-36; Splenopentin; CID121827
75957-60-7 (net), 105184-37-0 (acetate)
H-Arg-Lys-Glu-Val-Tyr-OH acetate salt
Molecular Formula
Long-term Storage Conditions
Splenopentin is an immunomodulatory pentapeptide which corresponds to the amino acids 32-36 (Arg-Lys-Glu-Val-Tyr) of the splenic hormone splenin.
Splenopentin exhibits the full bioactivity of the hormone splenin. Splenopentin increases white blood-cell production if suppressed, in addition to other immune-regulating compounds, which includes interleukin-3 and macrophage colony-stimulating factors.
Areas of Interest
Hormonal therapy
  • Background
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  • References

Splenopentin Acetate is a pentapeptide corresponding to the amino acid sequence 32 – 36 (Arg - Lys - Glu - Val - Tyr) of the splenic hormone splenin.

CAS: 90779-69-4
Sequence: 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-NH2 (Disulfide bond)
M.W: 994.2
Molecular Formula: C45H71N11O14S2
CAS: 103300-74-9
Sequence: (1-methyl-4,5-dihydroorotyl)- His-Pro-NH2
M.W: 477.46
Molecular Formula: C17H23N7O5
CAS: 16960-16-0
Sequence: H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH acetate salt
M.W: 2933.5
Molecular Formula: C136H210N40O31S
CAS: 57773-63-4 (net), 124508-66-3 (pamoate salt)
Sequence: Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 pamoate salt
M.W: 1744.96
Molecular Formula: C64H82N18O13
CAS: 581-05-5 (net)
Sequence: Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 acetate salt
M.W: 1664.91
Molecular Formula: C77H109N21O19S

Splenopentin (SP-5, Arg-Lys-Glu-Val-Tyr) and thymopentin (TP-5, Arg-Lys-Asp-Val-Tyr) are synthetic immunomodulating peptides corresponding to the region 32-34 of a splenic product called splenin (SP) and the thymic hormone thymopoietin (TP), respectively. TP was originally isolated as a 5-kDa (49-amino acids) protein from bovine thymus while studying effects of the thymic extracts on neuromuscular transmission and was subsequently observed to affect T cell differentiation and function. TP I and II are two closely related polypeptides isolated from bovine thymus. A radioimmunoassay for TP revealed a crossreaction with a product found in spleen and lymph node. This product, named splenin, differs from TP only in position 34, aspartic acid for bovine TP and glutamic acid for bovine splenin and it was called TP III as well. Synthetic pentapeptides (TP-5) and (SP-5), reproduce the biological activities of TP and SP, respectively. It is now evident that various forms of TPs were created by proteolytic cleavage of larger proteins during isolation, cDNA clones have been isolated for three alternatively spliced mRNAs that encodes three distinct human T cell TPs. The immunomodulatory properties of TP, SP, TP-5, SP-5 and some of their synthetic analogs reported in the literature have been briefly reviewed.

Singh, V. K., Biswas, S., Mathur, K. B., Haq, W., Garg, S. K., & Agarwal, S. S. (1998). Thymopentin and splenopentin as immunomodulators. Immunologic research, 17(3), 345-368.

Splenopentin, Arg-Lys-Glu-Val-Tyr (SP-5) and its synthetic analogs; Arg-d-Lys-Glu-Val-Tyr (pentapeptide 1), Lys-Lys-Glu-Val-Tyr (2), d-Lys-Lys-Glu-Val-Tyr (3), Arg-Lys-Gly-Val-Tyr (4), and Arg-Lys-Gln-Val-Tyr (5) have been examined for augmentation of human natural killer (NK) cell activity and human T-cell transformation response. Pentapeptides 2 and 3 were found to significantly augment the in vitro human NK cell activity. However, none of them had any effect on lymphocyte proliferative responses.

Rastogi, A., Singh, V. K., Biswas, S., Haq, W., Mathur, K. B., & Agarwal, S. S. (1993). Augmentation of human natural killer cells by splenopentin analogs. FEBS letters, 317(1-2), 93-95.

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