Asp-Phe

L-Aspartyl-L-phenylalanine is a dipeptide inhibitor of angiotensin-converting enzyme (ACE) and a metabolite of the synthetic non-caloric sweetener aspartame. It is formed from aspartame by intestinal intracellular esterases. L-Aspartyl-L-phenylalanine inhibits ACE with a Ki value of 11 µM for the rabbit enzyme. Serum levels of L-aspartyl-L-phenylalanine are positively associated with pancreatic ductal adenocarcinoma.

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Asp-Phe(CAS 13433-09-5)

CAT No: 10-101-305

CAS No: 13433-09-5

Synonyms/Alias: L-Aspartyl-L-phenylalanine;13433-09-5;H-ASP-PHE-OH;ASP-PHE;Aspartyl-phenylalanine;Aspartylphenylalanine;Demethylaspartame;l-a-aspartyl-l-phenylalanine;CHEBI:73830;L-alpha-Aspartyl-L-phenylalanine;(S)-3-Amino-4-(((S)-1-carboxy-2-phenylethyl)amino)-4-oxobutanoic acid;a-Aspartylphenylalanine;alpha-L-Aspartyl-L-phenylalanine;EINECS 236-557-3;(3S)-3-amino-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acid;a-L-Aspartyl-L-phenylalanine;N-L-aspartyl-L-PhenylAlanine;CHEMBL170376;N-L-a-aspartyl-L-PhenylAlanine;N-L-alpha-aspartyl-L-PhenylAlanine;alpha-Aspartylphenylalanine;3-amino-N-(carboxyphenethyl)-Succinamic acid stereoisomer;3.Aspartame acid;3-amino-N-(a-carboxyphenethyl)-Succinamic acid stereoisomer;(S)-3-amino-4-((S)-1-carboxy-2-phenylethylamino)-4-oxobutanoic acid;MFCD00063155;.alpha.L-Aspartyl-L-phenylalanine;DF dipeptide;(3S)-3-amino-4-(((1S)-1-carboxy-2-phenylethyl)amino)-4-oxobutanoic acid;L-Aspartyl-L-phenylalanine; Aspartame Imp. B (EP); Aspartame Impurity B;alpha-Asp-Phe;D-F Dipeptide;L-a-Asp-L-phe;L-alpha-Asp-L-Phe;L-Asp-L-Phe;N-L-alpha-Aspartyl-3-phenyl-L-alanine;N-Aspartylphenylalanine;Asp-Phe, 96%;N-alpha-Aspartylphenylalanine;SCHEMBL135366;alphaL-Aspartyl-L-phenylalanine;N-L-alpha-Aspartylphenylalanine;Aspartate Phenylalanine dipeptide;Aspartate-Phenylalanine dipeptide;DTXSID20928570;YZQCXOFQZKCETR-UWVGGRQHSA-N;n-alpha-l-aspartyl-l-phenylalanine;13433-09-5 (free amine);Aspartic acid phenylalanine dipeptide;Aspartic acid-phenylalanine dipeptide;BDBM50049759;MSK001019;AKOS022180930;AS-46818;FA108005;1ST001019;CS-0044366;NS00014795;L-alpha-Aspartyl-L-phenylalanine Hydrochloride;F10617;N-L-alpha-Aspartyl-L-phenylalanine Hydrochloride;Q27144148;

Chemical Name: (3S)-3-amino-4-[[(1S)-1-carboxy-2-phenylethyl]amino]-4-oxobutanoic acid

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Specification Technical Data Publications Customer reviews and Q&A
M.F/FormulaC13H16N2O5
M.W/Mr.280.28
SequenceOne Letter Code:DF
Three Letter Code:H-Asp-Phe-OH
Purity>98 %
ActivityInhibitor
TargetAngiotensin-converting Enzyme (ACE)
Shipping Condition+20°C (International: -20°C)
InChIInChI=1S/C13H16N2O5/c14-9(7-11(16)17)12(18)15-10(13(19)20)6-8-4-2-1-3-5-8/h1-5,9-10H,6-7,14H2,(H,15,18)(H,16,17)(H,19,20)/t9-,10-/m0/s1
InChI KeyYZQCXOFQZKCETR-UWVGGRQHSA-N
Canonical SMILESC1=CC=C(C=C1)CC(C(=O)O)NC(=O)C(CC(=O)O)N
Isomeric SMILESC1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)O)N

1. Peptides as Active Ingredients: A Challenge for Cosmeceutical Industry

2. Odorant binding protein based biomimetic sensors for detection of alcohols associated with Salmonella contamination in packaged beef

3. Effect of Probiotic Lactobacillus plantarum on Streptococcus mutans and Candida albicans Clinical Isolates from Children with Early Childhood Caries

4. The effect of sex on immune responses to a homocitrullinated peptide in the DR4-transgenic mouse model of Rheumatoid Arthritis

5. Exosomes-mediated Transfer of miR-125a/b in Cell-to-cell Communication: A Novel Mechanism of Genetic Exchange in the Intestinal Microenvironment

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