Disitertide

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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CAT#10-101-282
ExplanationDisitertide (P144) is a TGF-β1 antagonist peptide; induces apoptosis in GBM cell lines and reduces SMAD2 phosphorylation with downregulation of SKI and upregulation of SMAD7 at both transcriptional and translational levels; active in vivo.
Synonyms/AliasP144;P144 Peptide
M.F/FormulaC68H109N17O22S2
M.W/Mr.1580.8
SequenceOne Letter Code: TSLDASIIWAMMQN
Three Letter Code: H-Thr-Ser-Leu-Asp-Ala-Ser-Ile-Ile-Trp-Ala-Met-Met-Gln-Asn-OH
Purity>97% (by HPLC)
ActivityInhibitor
Biological ActivityDisitertide (P144) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) is also a PI3K inhibitor and an apoptosis inducer
TargetTGF-beta/Smad
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