Disitertide (P144) is a TGF-β1 antagonist peptide; induces apoptosis in GBM cell lines and reduces SMAD2 phosphorylation with downregulation of SKI and upregulation of SMAD7 at both transcriptional and translational levels; active in vivo.
CAT# | 10-101-282 |
CAS | 272105-42-7 |
Synonyms/Alias | P144;P144 Peptide |
M.F/Formula | C68H109N17O22S2 |
M.W/Mr. | 1580.8 |
Sequence | One Letter Code: TSLDASIIWAMMQN Three Letter Code: H-Thr-Ser-Leu-Asp-Ala-Ser-Ile-Ile-Trp-Ala-Met-Met-Gln-Asn-OH |
Purity | >97% (by HPLC) |
Activity | Inhibitor |
Biological Activity | Disitertide (P144) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) is also a PI3K inhibitor and an apoptosis inducer |
Target | TGF-beta/Smad |
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