G280-9 is a 9 amino acid native epitope peptide. G280-9 is a relevant target expressed on melanoma.
CAT No: R1367
CAS No:156761-76-1
Synonyms/Alias:95 kDa Melanocyte-Specific Secreted Glycoprotein (256-264) (human, bovine, mouse), Melanocyte Lineage-Specific Antigen GP100 (256-264) (human, bovine, mouse), ME20-M/ME20-S (256-264) (human, bovine, mouse), ME20M/ME20S (256-264) (human, bovine, mouse), Me
G280-9 is a synthetic peptide compound designed for advanced biochemical research applications, offering a defined amino acid sequence that enables precise modulation of biological pathways. As a member of the peptide family, G280-9 is valued for its capacity to mimic, inhibit, or probe specific protein interactions, making it a versatile tool in molecular biology and life sciences. Its structural characteristics allow for targeted investigations into protein function, signal transduction, and cellular processes, supporting both fundamental research and the development of novel experimental methodologies. With its unique sequence and biochemical properties, G280-9 serves as a critical reagent for researchers seeking to elucidate complex biological mechanisms or develop peptide-based technologies.
Peptide-Protein Interaction Studies: One of the primary applications of G280-9 lies in the detailed examination of peptide-protein interactions. By acting as a molecular probe, this peptide enables researchers to investigate binding affinities, specificity, and conformational dynamics between peptides and their protein targets. Such studies are essential for mapping interaction domains, characterizing receptor-ligand relationships, and identifying critical residues involved in biological recognition processes. The insights gained from these experiments can inform the rational design of inhibitors or modulators for diverse biochemical pathways.
Signal Transduction Research: G280-9 is frequently employed in the study of cellular signal transduction mechanisms. Its defined sequence can be used to activate or inhibit specific signaling cascades, providing a controlled means to dissect pathway components and downstream effects. Through targeted application in cell-based assays or in vitro systems, the peptide helps clarify the roles of individual proteins within complex networks, supporting the identification of key regulators and potential intervention points in cellular communication.
Peptide Synthesis and Modification: The compound serves as a valuable template in peptide synthesis and modification research. It can be utilized as a reference for optimizing solid-phase or solution-phase synthesis protocols, as well as for studying structure-activity relationships through systematic sequence alterations. Researchers can employ G280-9 to evaluate the impact of specific amino acid substitutions, post-translational modifications, or conjugation strategies, thereby advancing the development of custom peptides with enhanced stability, bioavailability, or functional activity.
Analytical Method Development: In analytical biochemistry, G280-9 is an important standard or calibration reagent for method development and validation. Its well-characterized sequence and physicochemical properties make it suitable for use in high-performance liquid chromatography (HPLC), mass spectrometry, and electrophoretic analyses. By providing a reliable benchmark, the peptide assists in the accurate quantification, identification, and characterization of peptides and proteins in complex biological samples, supporting robust data generation and quality control.
Functional Assays and Screening: The peptide is also instrumental in the design and execution of functional assays and high-throughput screening platforms. Researchers can incorporate G280-9 into assay systems to monitor enzymatic activity, receptor binding, or cellular responses under defined conditions. Its application facilitates the assessment of compound libraries, the discovery of novel modulators, and the validation of assay performance. This versatility supports a wide range of experimental objectives, from basic mechanistic studies to early-stage drug discovery initiatives.
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