PD-1/PD-L1 Inhibitor 3
PD-1/PD-L1 Inhibitor is a macrocyclic inhibitor of PD-1/PD-L1 interaction with an IC50 of 5.6 nM. In vitro ab231310 is capable of inhibiting the interaction of PD-L1 with PD-1 and with CD80. It has highly efficacious binding to PD-L1 and promotes enhanced T cell functional activity.
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| CAT# | R1891 |
| CAS | 1629654-95-0 |
| Synonyms/Alias | Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 3 |
| Chemical Name | (3S,6S,12S,15S,18S,21S,24S,27S,30R,39S,42S,47aS)-3-((1H-imidazol-5-yl)methyl)-12,18-bis((1H-indol-3-yl)methyl)-N,42-bis(2-amino-2-oxoethyl)-36-benzyl-21,24-dibutyl-27-(3-guanidinopropyl)-15-(hydroxymethyl)-6-isobutyl-8,20,23,38,39-pentamethyl-1,4,7,10,13, |
| M.F/Formula | C89H126N24O18S |
| M.W/Mr. | 1852.2 |
| Purity | ≥97% by HPLC |
| Source# | Synthetic |
Solubility | Soluble in DMSO |
Shipping Condition | RT, or blue ice upon request. |
InChI Key | XAUDCIZFSQEZFS-YZZQCSFYSA-N |
Canonical SMILES | CCCCC1C(=O)NC(C(=O)NC(CSCC(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)N(CC(=O)NC(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N1C)CCCC)C)CC3=CNC4=CC=CC=C43)CO)CC5=CNC6=CC=CC=C65)C)CC(C)C)CC7=CN=CN7)CC(=O)N)C)C)CC8=CC=CC=C8)C(=O)NCC(=O)N)CCCNC(=N)N |
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