Pexiganan is composed of 22 amino acids. In clinical manifestations, it has the advantages of low possibility of inducing drug resistance and no cross-resistance of existing therapeutic antibiotics. Pexiganan is a kind of cationic peptide with a strong antibacterial effect, with the characteristics of small molecular weight, rapid synthesis, rapid diffusion, strong alkalinity, high thermal stability, good water solubility, and unique antibacterial mechanism. Pexiganan has the broad-spectrum antibacterial ability, and it can kill viruses and tumor cells. More importantly, Pexiganan has no obvious toxic effect on normal cells of higher animals.
CAT No: R1838
CAS No:147664-63-9
Synonyms/Alias:Pexiganan;147664-63-9;Pexiganan [INN];TVF29Q70Q1;PEXIGANAN [MI];UNII-TVF29Q70Q1;7-L-LYSINE-8-L-LYSINE-10-L-LYSINE-18-L-LYSINE-19-DE-L-GLUTAMIC ACID-21-L-LEUCINE-23-L-LYSINAMIDE MAGAININ I;GLY-ILE-GLY-LYS-PHE-LEU-LYS-LYS-ALA-LYS-LYS-PHE-GLY-LYS-ALA-PHE-VAL-LYS-ILE-LEU-LYS-LYS-NH2;L-Lysinamide, glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylaalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-;L-Lysinamide, glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-;Magainin I, 7-L-lysine-8-L-lysine-10-L-lysine-18-L-lysine-19-de-L-glutamic acid-21-L-leucine-23-L-lysinamide;pexigananum;SCHEMBL476400;CHEMBL1275802;EX-A7466;DA-56715;FP138116;Glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-L-lysinamide;L-Lysinamide, glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucy l-L-lysyl-;L-Lysinamide,glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-;
Pexiganan is a synthetic antimicrobial peptide derived from the magainin family, originally isolated from the skin of the African clawed frog (Xenopus laevis). As a cationic, amphipathic peptide, it exhibits broad-spectrum activity against a variety of Gram-positive and Gram-negative bacteria, making it a valuable tool in the study of innate immune mechanisms and peptide-based antimicrobial strategies. Its unique structure and membrane-targeting mode of action have established pexiganan as a prominent subject in peptide research, particularly in the context of antimicrobial resistance and novel therapeutic approaches. Researchers are increasingly interested in its ability to disrupt bacterial membranes without relying on traditional antibiotic targets, positioning it at the forefront of next-generation antimicrobial research.
Antimicrobial mechanism studies: Pexiganan is widely employed in elucidating the molecular basis of peptide-induced bacterial cell lysis. By integrating it into in vitro assays, scientists can investigate membrane permeabilization, pore formation, and the sequence-structure relationships that drive selective toxicity toward microbial cells. These studies are crucial for understanding how cationic peptides interact with lipid bilayers and for guiding the rational design of new antimicrobial agents with improved efficacy and specificity.
Peptide structure-activity relationship research: The distinctive primary and secondary structure of pexiganan renders it a model system for exploring the structure-activity relationships (SAR) of antimicrobial peptides. Through systematic modifications and comparative analyses, researchers can assess how specific amino acid substitutions, sequence truncations, or cyclization affect antimicrobial potency and selectivity. Such SAR investigations provide foundational insights into peptide engineering, enabling the development of optimized analogs for diverse scientific applications.
Biofilm disruption assays: Pexiganan is utilized in the study of biofilm formation and eradication, addressing a critical challenge in microbiology and biotechnology. Its ability to penetrate and disrupt established biofilms is evaluated in various experimental models, helping researchers understand the mechanisms by which peptides overcome biofilm-associated resistance. These insights are instrumental in developing strategies to control biofilm-related contamination in industrial, environmental, and laboratory settings.
Synergy evaluation with conventional antimicrobials: The peptide is frequently assessed in combination studies with traditional antibiotics to identify potential synergistic effects. By examining its interactions with established antimicrobial agents, scientists can determine whether co-administration enhances bacterial killing or mitigates resistance development. Such combination studies are highly relevant for optimizing antimicrobial regimens and for informing the design of multi-modal approaches to bacterial control in research and industrial microbiology.
Peptide formulation and delivery research: As a representative cationic antimicrobial peptide, pexiganan serves as a model compound in the development of advanced delivery systems. Researchers investigate its stability, bioavailability, and controlled release in various matrices, including hydrogels, nanoparticles, and polymer-based carriers. These formulation studies are essential for addressing challenges related to peptide degradation, targeted delivery, and sustained antimicrobial action, ultimately supporting the translation of peptide-based technologies into practical research tools and industrial applications.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More