Pexiganan

Pexiganan is composed of 22 amino acids. In clinical manifestations, it has the advantages of low possibility of inducing drug resistance and no cross-resistance of existing therapeutic antibiotics. Pexiganan is a kind of cationic peptide with a strong antibacterial effect, with the characteristics of small molecular weight, rapid synthesis, rapid diffusion, strong alkalinity, high thermal stability, good water solubility, and unique antibacterial mechanism. Pexiganan has the broad-spectrum antibacterial ability, and it can kill viruses and tumor cells. More importantly, Pexiganan has no obvious toxic effect on normal cells of higher animals.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R1838

CAS No:147664-63-9

Synonyms/Alias:Pexiganan;147664-63-9;Pexiganan [INN];TVF29Q70Q1;PEXIGANAN [MI];UNII-TVF29Q70Q1;7-L-LYSINE-8-L-LYSINE-10-L-LYSINE-18-L-LYSINE-19-DE-L-GLUTAMIC ACID-21-L-LEUCINE-23-L-LYSINAMIDE MAGAININ I;GLY-ILE-GLY-LYS-PHE-LEU-LYS-LYS-ALA-LYS-LYS-PHE-GLY-LYS-ALA-PHE-VAL-LYS-ILE-LEU-LYS-LYS-NH2;L-Lysinamide, glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylaalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-;L-Lysinamide, glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-;Magainin I, 7-L-lysine-8-L-lysine-10-L-lysine-18-L-lysine-19-de-L-glutamic acid-21-L-leucine-23-L-lysinamide;pexigananum;SCHEMBL476400;CHEMBL1275802;EX-A7466;DA-56715;FP138116;Glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-L-lysinamide;L-Lysinamide, glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucy l-L-lysyl-;L-Lysinamide,glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C122H210N32O22
M.W/Mr.
2477.2
Sequence
One Letter Code:GIGKFLKKAKKFGKAFVKILKK
Three Letter Code:H-Gly-Ile-Gly-Lys-Phe-Leu-Lys-Lys-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Lys-Ile-Leu-Lys-Lys-NH2
Appearance
White or off-white lyophilized powder
Purity
min 95%
Shipping Condition
Shipped at room temperature
InChI
InChI=1S/C122H210N32O22/c1-13-77(9)102(152-98(155)71-132)120(174)135-73-100(157)139-86(50-26-35-59-125)110(164)150-96(69-82-44-20-16-21-45-82)118(172)148-93(66-74(3)4)116(170)145-90(54-30-39-63-129)113(167)142-87(51-27-36-60-126)109(163)137-79(11)105(159)141-88(52-28-37-61-127)112(166)143-91(55-31-40-64-130)114(168)149-95(68-81-42-18-15-19-43-81)107(161)134-72-99(156)138-85(49-25-34-58-124)108(162)136-80(12)106(160)147-97(70-83-46-22-17-23-47-83)119(173)153-101(76(7)8)121(175)146-92(56-32-41-65-131)115(169)154-103(78(10)14-2)122(176)151-94(67-75(5)6)117(171)144-89(53-29-38-62-128)111(165)140-84(104(133)158)48-24-33-57-123/h15-23,42-47,74-80,84-97,101-103H,13-14,24-41,48-73,123-132H2,1-12H3,(H2,133,158)(H,134,161)(H,135,174)(H,136,162)(H,137,163)(H,138,156)(H,139,157)(H,140,165)(H,141,159)(H,142,167)(H,143,166)(H,144,171)(H,145,170)(H,146,175)(H,147,160)(H,148,172)(H,149,168)(H,150,164)(H,151,176)(H,152,155)(H,153,173)(H,154,169)/t77-,78-,79-,80-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,101-,102-,103-/m0/s1
InChI Key
KGZGFSNZWHMDGZ-KAYYGGFYSA-N

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