Angiotensin II 5-valine is an agonist of angiotensin receptor.
CAT No: HB00120
CAS No:58-49-1
Synonyms/Alias:58-49-1;Angiotensin II 5-valine;Asp-Arg-Val-Tyr-Val-His-Pro-Phe;Val(5)-angiotensin II;bovine angiotensin II;(Val5)-Angiotensin II H-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH;CHEMBL216830;CHEBI:48434;(Val5)-Angiotensin II;(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid;Valine angiotensin II;L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-L-phenylalanine;MFCD00167495;AspArgValTyrValHisProPh;[Val5] - ANGIOTENSIN II;HY-P0108;BDBM50048128;CS-5786;DA-48913;MS-31880;F85422;Asp-Arg-Val-Tyr-Val-His-Pro-Phe (Angiotensin II);Q27121202;[Asp1-Arg2-Val3-Tyr4-Val5-His6-Pro7-Phe8](angiotensin II);(Val5)-Angiotensin II (H-L-Asp-L-Arg-L-Val-L-Tyr-L-Val-L-His-L-Pro-L-Phe-OH);(2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-5-yl)methyl)-17-amino-1-((S)-2-(((S)-1-carboxy-2-phenylethyl)carbamoyl)pyrrolidin-1-yl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-5,11-diisopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazanonadecan-19-oic acid;
Angiotensin Acetate is a synthetic peptide derivative that plays a pivotal role in the study of cardiovascular physiology and peptide signaling pathways. Structurally, it is based on the naturally occurring angiotensin peptide, a key regulator within the renin-angiotensin system (RAS) that influences blood pressure, fluid balance, and vascular tone. Its acetate salt form enhances stability and solubility, making it a preferred choice for laboratory research. Due to its well-characterized mechanism of action and high relevance to vascular biology, Angiotensin Acetate is widely utilized in experimental models aiming to elucidate peptide-mediated signaling and receptor interactions.
Receptor binding studies: Angiotensin Acetate serves as a valuable tool for investigating angiotensin receptor specificity and affinity, particularly in the context of AT1 and AT2 receptor subtypes. Researchers employ this peptide to characterize binding kinetics, competitive inhibition, and downstream signaling cascades in cell-based assays or tissue preparations. By enabling precise modulation of receptor activity, it supports the dissection of complex signaling networks that govern vascular function and homeostasis.
Signal transduction research: The compound is extensively used to probe the intracellular pathways activated by angiotensin peptides. Its application allows for the controlled stimulation of G protein-coupled receptor (GPCR) pathways, leading to the activation of secondary messengers such as phospholipase C, inositol trisphosphate, and calcium ions. Through these studies, scientists can delineate the molecular events underlying vasoconstriction, aldosterone secretion, and other physiological responses, thereby advancing the understanding of peptide hormone signaling.
Peptide synthesis and analog development: Angiotensin Acetate is frequently employed as a reference standard or starting material in the synthesis of novel peptide analogs. Its well-defined sequence and reactivity provide a foundation for structure-activity relationship (SAR) studies aimed at optimizing biological activity or receptor selectivity. Synthetic chemists utilize this peptide to design and evaluate modified analogs with altered pharmacodynamic profiles, supporting the development of innovative research tools and molecular probes.
Vascular function assays: The peptide is instrumental in functional assays designed to assess vascular reactivity, endothelial function, and smooth muscle contractility. By applying controlled concentrations to isolated vessel segments or perfused organ systems, researchers can monitor changes in tone, contractile response, and signaling dynamics. These experiments yield critical insights into the mechanisms of vasoregulation and the potential impact of peptide modulators on cardiovascular physiology.
Pharmacological screening: Angiotensin Acetate is widely used in high-throughput screening platforms to identify modulators of the renin-angiotensin system. Its application in biochemical and cellular assay formats enables the evaluation of candidate molecules for antagonist or agonist activity at angiotensin receptors. Such screening efforts are fundamental to the discovery and characterization of new compounds with potential utility in cardiovascular research and peptide-based drug development.
1. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
4. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die
5. Immune-awakening Saccharomyces-inspired nanocarrier for oral target delivery to lymph and tumors
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More