Depreotide

Depreotide is a peptide analogue of a somatostatin receptor that preferentially binds to somatostatin receptors 2, 3, and 5. Many lung tumors may express these receptors to a greater extent than normal tissue. Depreotide study is a noninvasive, receptor-specific imaging agent that is used to assess malignant versus benign single pulmonary nodules before biopsy.

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CAT#10-101-102
CAS161982-62-3
Background

Tc-99m labeled somatostatin receptor-binding peptide (Depreotide) has received US Food and Drug Administration approval for use in the imaging of suspected malignant tumors in the lung. This agent has been utilized in the evaluation of solitary pulmonary nodules and has shown a specificity of 73.1% to 88% and a sensitivity of 93% to 96.6% for detection of malignant solitary pulmonary nodules. The authors therefore concluded that Depreotide is a safe and useful method for the non-invasive evaluation of solitary pulmonary nodules with a sensitivity and accuracy comparable to that reported for FDG PET.  >> Read More

Synonyms/AliasNeoTec; P 829; P829; D03687; P-829
Chemical Name(2S)-6-amino-2-[[(2R)-2-[[(2S)-6-amino-2-[[(2S)-2-amino-3-[[2-[2-[(2S,5S,8S,11R,14S,17S)-14-(4-aminobutyl)-5-benzyl-8-[(4-hydroxyphenyl)methyl]-11-(1H-indol-3-ylmethyl)-4-methyl-3,6,9,12,15,18-hexaoxo-17-propan-2-yl-1,4,7,10,13,16-hexazacyclooctadec-2-yl]ethylsulfanyl]acetyl]amino]propanoyl]amino]hexanoyl]amino]-3-sulfanylpropanoyl]amino]hexanamide;technetium
M.F/FormulaC65H96N16O12S2
M.W/Mr.1357.69
SequenceCyclo(L-homocysteinyl-N-methyl-L-phenylalanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl) (1-1')-sulfide with 3-((mercaptoacetyl)amino)-L-alanyl-L-lysyl-L-cysteinyl-L-lysinamide
Labeling TargetSomatostatin receptor
ApplicationRadiodiagnostic agent
Areas of InterestCancer treatment
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