Carbetocin (trade name Duratocin) is an eight amino acid long analogue of oxytocin (a nonapeptide) with improved in vivo stability over oxytocin. Carbetocin primarily agonizes peripherally expressed oxytocin receptors.
CAT No: 10-101-42
CAS No:37025-55-1
Synonyms/Alias:Carbetocin acetate;(S)-1-((3R,6S,9S,12S,15S)-6-(2-Amino-2-oxoethyl)-9-(3-amino-3-oxopropyl)-12-((S)-sec-butyl)-15-(4-methoxybenzyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacycloicosane-3-carbonyl)-N-((S)-1-((2-amino-2-oxoethyl)amino)-4-methyl-1-oxopentan-2-yl)pyrr;1936459-26-5;
Chemical Name:acetic acid;N-[1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-1-[6-(2-amino-2-oxoethyl)-9-(3-amino-3-oxopropyl)-12-butan-2-yl-15-[(4-methoxyphenyl)methyl]-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carbonyl]pyrrolidine-2-carboxamide
Carbetocin Acetate is a synthetic peptide analog of the naturally occurring hormone oxytocin, distinguished by its enhanced stability and prolonged biological activity. Engineered for research and development purposes, Carbetocin Acetate exhibits a high affinity for oxytocin receptors, enabling it to mimic and extend the physiological effects of endogenous oxytocin. Its peptide backbone has been modified to resist enzymatic degradation, making it a valuable tool in studies requiring sustained receptor activation. The compound is typically supplied as a lyophilized powder, which can be reconstituted in aqueous solutions for various laboratory protocols. Researchers value its reliable performance, reproducibility, and compatibility with diverse experimental designs in the fields of life sciences, biochemistry, and molecular biology.
Receptor Binding Studies: Carbetocin Acetate serves as a critical probe in receptor binding assays, allowing scientists to investigate the pharmacodynamics of oxytocin receptor interactions. By incorporating this compound into competitive binding experiments, researchers can quantify receptor density, affinity, and specificity in different tissue samples or cell lines. These studies provide crucial insights into the molecular mechanisms underlying oxytocin-mediated signaling pathways and facilitate the identification of potential modulators or antagonists. Carbetocin's resistance to rapid degradation ensures consistent and interpretable results, even in complex biological matrices.
Signal Transduction Research: In the context of intracellular signaling, Carbetocin is frequently utilized to stimulate oxytocin receptors and monitor downstream effects such as calcium mobilization, phosphorylation events, and gene expression changes. Its prolonged activity allows for the observation of both immediate and sustained cellular responses, making it ideal for dissecting the temporal dynamics of oxytocin-mediated pathways. These investigations contribute to a deeper understanding of G protein-coupled receptor (GPCR) signaling networks and their role in physiological and behavioral processes.
Neuroendocrine Regulation Studies: The use of Carbetocin Acetate in neuroendocrine research enables the exploration of oxytocin's influence on hormone secretion, neuronal activity, and feedback mechanisms within the hypothalamic-pituitary axis. By administering the compound in in vitro or ex vivo systems, researchers can evaluate its effects on neural circuits and endocrine outputs. Such studies are essential for elucidating the broader role of oxytocin analogs in modulating stress responses, social behaviors, and homeostatic regulation.
Behavioral Science Research: Carbetocin is increasingly adopted in behavioral science to model and analyze the impact of oxytocinergic signaling on social interaction, bonding, and emotional regulation in animal models. Its stability and receptor selectivity make it an effective agent for probing the neurobiological substrates of social cognition and affiliative behaviors. Experimental paradigms utilizing Carbetocin facilitate the identification of neural pathways and molecular targets involved in complex behavioral phenotypes, advancing the field of neuropsychology and behavioral genetics.
Comparative Pharmacology: In comparative pharmacological studies, Carbetocin Acetate is employed to contrast its efficacy, duration of action, and receptor selectivity with other oxytocin analogs and peptide hormones. These investigations help delineate structure-activity relationships and inform the design of novel compounds with tailored pharmacokinetic profiles. By systematically evaluating Carbetocin alongside related peptides, researchers gain valuable data on the determinants of receptor activation, signal amplification, and physiological outcomes, thereby supporting the rational development of next-generation oxytocin receptor modulators.
Peptide Engineering and Drug Development: Carbetocin Acetate also plays a pivotal role in peptide engineering, where its structural modifications are analyzed to optimize stability, receptor affinity, and bioavailability. Researchers utilize it as a reference molecule to benchmark new analogs or to develop delivery systems that enhance peptide therapeutics' performance. Its robust properties and well-characterized activity profile make Carbetocin an indispensable tool in preclinical studies aimed at expanding the therapeutic potential of peptide-based agents and advancing translational research in the field of neuropeptide science.
1. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis
4. Cationic cell-penetrating peptides are potent furin inhibitors
5. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More