Carbetocin Acetate

Carbetocin (trade name Duratocin) is an eight amino acid long analogue of oxytocin (a nonapeptide) with improved in vivo stability over oxytocin. Carbetocin primarily agonizes peripherally expressed oxytocin receptors.

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CAT#10-101-42
Chemical Structure
CAS37025-55-1
Synonyms/AliasCalcihexal; Calcimar; Forcaltonin; Fortical; Miacalcic; Miacalcin; Carbetocino; Carbetocinum; CID71715; EINECS 253-312-6; AC-3444; DB01282; I06-1830; AC3444; AC 3444; I06 1830
Chemical Nameacetic acid;N-[1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-1-[6-(2-amino-2-oxoethyl)-9-(3-amino-3-oxopropyl)-12-butan-2-yl-15-[(4-methoxyphenyl)methyl]-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carbonyl]pyrrolidine-2-carboxamide
M.F/FormulaC47H73N11O14S
M.W/Mr.1048.21
SequenceThree Letter Code: Butyryl-Tyr(Me)-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2(Disulfide bond)
ApplicationCarbetocin is a drug used to control postpartum hemorrhage, bleeding after giving birth, since it causes contraction of the uterus.
ActivityAgonist
Biological ActivityCarbetocin acetate, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin acetate has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (Ki=1.17 μM). Carbetocin acetate has the potential for postpartum hemorrhage research. Carbetocin acetate can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS.
TargetOxytocin Receptor
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