Econazole Sulfosalicylate is an antifungal agent applied topically or intravaginally. Econazole, an imidazole derivative, is indicated in the treatment of skin infections such as dermatophytosis, superficial candidasis, and tinea versicolor, and of infections of the nails. Econazole is also used as a topical antimycotic in veterinary medicine.
CAT No: 10-101-116
CAS No:27220-47-9 (net), 118308-71-7 (sulfosalicylate)
Synonyms/Alias:1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole sulfosalicylate; SQ-13050 sulfosalicylate; 1-[2,4-Dichloro-β-(4-chlorobenzyloxy)phenethyl]-imidazole sulfosalicylate
Chemical Name:1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole;2-hydroxy-5-sulfobenzoic acid
Econazole Sulfosalicylate is a unique carbohydrate compound that merges the antifungal properties of econazole with the solubility-enhancing capabilities of sulfosalicylate. As a result of this combination, the product offers a versatile option for researchers and formulators seeking to address the challenges associated with poorly soluble active pharmaceutical ingredients. The molecular structure of econazole sulfosalicylate facilitates improved aqueous solubility and stability, making it an attractive candidate for a variety of scientific and industrial applications. Its compatibility with a range of excipients and its ability to maintain the biological activity of econazole further enhance its appeal for research and development in multiple fields. This compound is especially valued in the synthesis of advanced formulations, where solubility and bioavailability are critical parameters for achieving optimal performance.
Pharmaceutical research: In pharmaceutical research, econazole sulfosalicylate is widely utilized for the development and optimization of antifungal formulations. The combination of econazole with sulfosalicylate not only enhances the solubility of the active compound but also supports the creation of novel dosage forms such as creams, gels, and sprays. Researchers leverage its improved physicochemical properties to design delivery systems that maximize the local availability of econazole, thereby facilitating the study of its antifungal efficacy in vitro. The compound's unique profile allows for the exploration of new formulation strategies that address the limitations of conventional econazole salts, supporting innovation in the treatment of fungal infections at the laboratory level.
Formulation science: In the field of formulation science, econazole sulfosalicylate serves as a model compound for investigating the impact of salt formation on drug solubility and stability. Scientists employ it to examine how sulfosalicylate ions interact with active pharmaceutical ingredients, thereby influencing dissolution rates and shelf-life. This research aids in the rational design of formulations that require enhanced solubility, particularly for topical or transdermal delivery systems. By studying the behavior of this compound under various environmental conditions, formulation scientists gain valuable insights into the mechanisms that govern drug-excipient interactions, paving the way for the development of more effective and stable pharmaceutical products.
Analytical method development: Analytical chemists utilize econazole sulfosalicylate as a reference material and test compound when developing and validating new analytical methods. Its distinct chemical properties make it suitable for evaluating chromatographic techniques, such as HPLC and mass spectrometry, aimed at quantifying econazole derivatives in complex matrices. The compound's stability and solubility profile allow for the creation of robust calibration standards, which are essential for ensuring the accuracy and reproducibility of analytical results. As a result, it plays a crucial role in the advancement of quality control protocols and the standardization of analytical procedures in pharmaceutical laboratories.
Material science: In material science, econazole sulfosalicylate is explored for its potential to modify the surface properties of polymers and other substrates. Researchers investigate its application as a functional additive that imparts antifungal characteristics to coatings, films, and packaging materials. By incorporating this compound into various matrices, scientists can assess its effectiveness in inhibiting microbial growth and extending the shelf-life of sensitive products. The interaction between econazole sulfosalicylate and different material types offers valuable data on compatibility, stability, and performance, contributing to the innovation of antimicrobial materials for diverse industrial uses.
Biochemical studies: Biochemical researchers employ econazole sulfosalicylate to probe the mechanisms of antifungal action at the molecular level. By utilizing this compound in enzyme inhibition assays and cell culture experiments, scientists can dissect the pathways involved in fungal cell membrane disruption and ergosterol synthesis inhibition. The solubility advantages conferred by the sulfosalicylate moiety enable more precise dosing and improved experimental reproducibility, which are essential for elucidating the compound's mode of action. These studies not only advance the understanding of antifungal agents but also inform the design of next-generation compounds with enhanced efficacy and safety profiles. In summary, econazole sulfosalicylate is a multifaceted tool in scientific research, supporting advancements across pharmaceutical, analytical, material, and biochemical disciplines.
The aim of this investigation was to compare the contact action of econazole sulfosalicylate (E-SSA) on mycetes (Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Trichophyton rubrum, T. cutaneum, Pityrosporum sp.), Gram-positive bacteria (Staphylococcus aureus, Streptococcus faecalis) and Gram-negative bacteria (Escherichia coli, Citrobacter freundii) with that exerted by econazole nitrate (E-NIT). The results show E-SSA activity greater than E-NIT (in particular against mycetes and Gram-negative bacteria). The E-SSA contact activity trials illustrated certain properties of this imidazole sulfosolicylate such as: absence of latency time, antimicrobial activity proportional to its concentration, when a high concentration is used, given the limiting influence of pH and ionic strength of the medium. The higher E-SSA contact activity, in relation to E-NIT, can be correlated to its greater lipophylia considering also the lipophylic properties of SSA and the scarce dissociation of E-SSA.
Simonetti, N., Spignoli, G., D'Auria, F. D., & Strippoli, V. (1991). Antimicrobial Contact Activity of Econazole Sulfosalicylate. Journal of Chemotherapy, 3(2), 101-107.
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