Growth hormone releasing peptide (GHRP) that stimulates GH secretion. It is neuroprotective in the neonatal setting in vivo and alters Akt/glycogen synthase kinase-3-Beta phosphorylation. Hexarelin is relatively resistant to proteolytic degradation.
CAT No: HB00105
CAS No:140703-51-1
Synonyms/Alias:Hexarelin;Examorelin;140703-51-1;Examorelin [INN];examorelina;examoreline;L-Lysinamide, L-histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-;EP-23905;MF-6003;UNII-09QF37C617;EXAMORELIN [MART.];L-Histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide;09QF37C617;EXAMORELIN (MART.);(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(2-methyl-1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide;examorelinum;(S)-2-((2R,5S,8S,11R,14S)-5-((1H-indol-3-yl)methyl)-14-amino-2-benzyl-15-(1H-imidazol-4-yl)-8-methyl-11-((2-methyl-1H-indol-3-yl)methyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecanamido)-6-aminohexanamide;EP23905;EP 23905;His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2;SCHEMBL26959;CHEMBL108335;Hexarelin, >=90% (HPLC);SCHEMBL18428170;DTXSID401032408;BDBM50370294;AKOS040744417;FH73439;DA-64129;HY-19235;BRD-K35304636-001-01-0;Q21098927;
Hexarelin is a synthetic hexapeptide and potent growth hormone secretagogue that has become an important tool in biochemical and physiological research. As a member of the growth hormone-releasing peptide (GHRP) family, it is characterized by its ability to stimulate the secretion of endogenous growth hormone through interaction with the ghrelin receptor (GHS-R1a). Its structural stability and resistance to enzymatic degradation make it particularly valuable for in vitro and in vivo studies investigating peptide-receptor interactions, signal transduction, and endocrine regulation. Due to its defined sequence and robust biological activity, Hexarelin serves as a model compound for understanding the mechanisms underlying peptide-induced hormone release and related cellular processes.
Hormone Secretion Studies: Hexarelin is widely utilized in research focused on elucidating the mechanisms of growth hormone (GH) secretion. By binding to the GHS-R1a receptor, it triggers intracellular signaling cascades leading to enhanced GH release from pituitary cells. This property enables researchers to probe the physiological regulation of the somatotropic axis, dissect the receptor-ligand dynamics involved in peptide-mediated hormone release, and compare the efficacy and potency of various secretagogues under controlled experimental conditions.
Receptor Pharmacology: As a selective agonist of the ghrelin receptor, Hexarelin is instrumental in characterizing GHS-R1a pharmacology. It is frequently employed in receptor binding assays, signal transduction studies, and structure-activity relationship analyses. Through these approaches, investigators can map the functional domains of the receptor, identify critical residues for ligand binding, and assess the specificity and selectivity of new peptide analogs or small-molecule modulators. The compound's stability and reproducibility facilitate high-throughput screening and mechanistic studies in cellular and membrane-based assay systems.
Peptide Drug Development: The structural features and bioactivity profile of Hexarelin provide a valuable template for the rational design of novel peptide-based therapeutics. Medicinal chemists and peptide engineers use it as a reference compound to optimize sequence modifications, improve metabolic stability, and enhance receptor selectivity in the development of next-generation growth hormone secretagogues. Its robust activity in biochemical assays allows for systematic evaluation of analog libraries, supporting the advancement of peptide drug discovery pipelines.
Metabolic and Endocrine Research: Researchers investigating metabolic regulation, energy homeostasis, and endocrine signaling often incorporate Hexarelin into experimental models to dissect the interplay between growth hormone and metabolic pathways. Its ability to modulate GH levels provides a controlled means to study downstream effects on glucose metabolism, lipid turnover, and anabolic processes in various tissues. These applications are central to advancing knowledge of hormone-driven metabolic regulation and identifying molecular targets for further investigation.
Signal Transduction Analysis: Hexarelin is a preferred tool for dissecting intracellular signaling pathways activated by peptide ligands. By stimulating GHS-R1a, it initiates a cascade of events involving G-protein coupling, second messenger generation, and kinase activation, which can be monitored using a range of biochemical and molecular techniques. This enables detailed mapping of downstream effectors, cross-talk with other signaling networks, and identification of regulatory checkpoints within the context of peptide hormone action. Such studies are essential for understanding the complexity of peptide-mediated cellular responses and for informing the design of new experimental approaches in signal transduction research.
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