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LSKL, Inhibitor of Thrombospondin (TSP-1) is a peptide derived from the latency-associated peptide, inhibits thrombospondin (TSP-1) activation of TGF-β and prevents the progression of hepatic damage and fibrosis.
CAT No: R1490
CAS No: 283609-79-0
Synonyms/Alias: 283609-79-0;H-Leu-Ser-Lys-Leu-NH2;LSKL, Inhibitor of Thrombospondin (TSP-1);(2S)-6-amino-N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]hexanamide;H-Leu-Ser-Lys-Leu-NH2 trifluoroacetate salt;L-Leucyl-L-seryl-L-lysyl-L-leucinamide;LSKL-NH2;Leu-Ser-Lys-Leu peptide;leucyl-seryl-lysyl-leucyl peptide;LSKL;H-Leu-Ser-Lys-Leu-NH;TSP-1 inhibitor peptide LSKL;HY-P0299;Inhibitor of Thrombospondin ;TSP-1;AC-31401;DA-74214;FL109362;MS-28396;PD078448;Leu-Ser-Lys-Leu-NH2, >=95% (HPLC);G13182;LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA) LSKL;
Chemical Name: (2S)-6-amino-N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]hexanamide
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M.F/Formula | C21H42N6O5 |
M.W/Mr. | 458.6 |
Sequence | One Letter Code:LSKL Three Letter Code:H-Leu-Ser-Lys-Leu-NH2 |
Purity | ≥98% |
Source# | Synthetic |
Long-term Storage Conditions | DMSO : ≥ 100 mg/mL;H2O : 50 mg/mL (ultrasonic) |
Shipping Condition | Wet ice in continental US; may vary elsewhere |
InChI | InChI=1S/C21H42N6O5/c1-12(2)9-14(23)19(30)27-17(11-28)21(32)25-15(7-5-6-8-22)20(31)26-16(18(24)29)10-13(3)4/h12-17,28H,5-11,22-23H2,1-4H3,(H2,24,29)(H,25,32)(H,26,31)(H,27,30)/t14-,15-,16-,17-/m0/s1 |
InChI Key | YOKXDNNIFSAXBY-QAETUUGQSA-N |
Canonical SMILES | CC(C)CC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)N) |
Isomeric SMILES | CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N)N |
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