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Ornipressin

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CAT#
10-101-40
Synonyms/Alias
Ornithine Vasopressin; Ornithine-8-Vasopressin; Orpressin; POR-8; Ornipressina; Ornipressin; Ornipresina; POR8; POR 8
CAS No.
3397-23-7
Sequence
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Orn-Gly-NH2(Disulfide,Cys1 and Cys6)
M.W/Mr.
1042.19
Molecular Formula
C45H63N13O12S2
Source
Synthetic
Long-term Storage Conditions
−20°C
Application
Ornipressin is a vasoconstrictor, haemostatic and renal agent.
Description
Ornipressin (omithine-8-vasopressin, POR-8) is the most commonly used vasopressin analogue in Germany, Switzerland, New Zealand and Australia. While it has minimal antidiuretic activity whilst maintaining equipotent vasoconstrictor activity as the natural hormone, vasoprssin.
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  • Background
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Ornipressin is a potent vasoconstrictor agent, and plasma volume expansion with albumin to improve effective arterial blood volume. In vitro: Ornipressin produces a profound vasoconstrictive effect by contracting smooth-muscle cells in the vascular bed, especially in capillaries, small arterioles and venules. Ornipressin is most commonly used to treat bleeding oesophageal varices.

CAS: 201530-41-8
Sequence: ---
M.W: 373.3615
Molecular Formula: C21H15N3O4
CAS: 60731-46-6 (net)
Sequence: Cyclo(-Ser-Asn-Leu-Ser-Thr-Asu)-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ala-Gly-Thr-Pro-NH2 acetate salt
M.W: 3363.8
Molecular Formula: C148H244N42O47
CAS: 17035-90-4 (net), 53308-83-1 (acetate)
Sequence: H-Arg(Me)-OH acetate salt
M.W: 248.28
Molecular Formula: C9H20N4O4
CAS: 163913-87-9
Sequence: Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu -Tyr-Arg-Asn-Gly-Lys
M.W: 2581.99
Molecular Formula: C118H177N35O29S
CAS: 73385-60-1
Sequence: Tyr-Met(O)-Gly-(4-nitrophenyl)-Ala-ProNH2
M.W: 673.74
Molecular Formula: C30H39N7O9S

The haemostatic effect of a high concentration of ornipressin 5 IU/10 mls lidocaine was studied in 127 patients undergoing rhinosurgery under two types of general anaesthesia. Under halothane/enflurane anaesthesia blood pressure and heart rate remained nearly constant up to 15 minutes following local injection of ornipressin into the nasal tissues. Good haemostasis was achieved in 86.5 percent of cases. Under diazepam/fentanyl anaesthesia an elevation of blood pressure was observed following infiltration of ornipressin. Thus the high concentration cannot be recommended for cases with blood pressure dyscrasias. The haemostatic effect was either good in only 60 percent of the patients.

Sigg, O., Pirsig, W., & Hirlinger, W. K. (1983). Ornipressin as vasoconstrictor in rhinosurgery. Rhinology, 21(2), 159-164.

We sought to evaluate the efficacy and side effect profile of a small dose of ornipressin, a vasopressin agonist specific for the V1 receptor, administered to reverse the hypotension associated with combined general/epidural anesthesia. A total of 60 patients undergoing intestinal surgery were studied. After the induction of anesthesia, 7-8 mL of bupivacaine 0.5% with 2 microg/kg clonidine and 0.05 microg/kg sufentanil after an infusion of 5 mL of bupivacaine 0.06% with 0.5 microg x kg(-1) x h(-1) clonidine and 0.1 microg/h of sufentanil were administered by an epidural catheter placed at T7-8 vertebral interspace. When 20% reduction of baseline arterial blood pressure developed, patients were randomly assigned to receive, in a double-blinded design, dopamine started at 2 microg x kg(-1) x min(-1), norepinephrine started at 0.04 microg x kg(-1) x min(-1), or ornipressin started at 1 IU/h. Fifteen patients presenting without hypotension were used as control subjects. Beside routine monitoring, S-T segment analysis, arterial lactacidemia, and gastric tonometry were performed. Ornipressin restored arterial blood pressure after 8 +/- 2 vs 7 +/- 3 min in the norepinephrine group and 11 +/- 3 min in the dopamine group (P < 0.05). This effect was achieved with 2 IU/h of ornipressin in most of the patients (11 of 15). Ornipressin did not induce any modification of the S-T segment; however, it significantly increased intracellular gastric PCO(2) (P < 0.05), indicating splanchnic vasoconstriction.

De Kock, M., Laterre, P. F., Andruetto, P., Vanderessen, L., Dekrom, S., Vanderick, B., & Lavand’homme, P. (2000). Ornipressin (Por 8): an efficient alternative to counteract hypotension during combined general/epidural anesthesia. Anesthesia & Analgesia, 90(6), 1301-1307.

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