Peptide YY (3-36) (human) Acetate

The gut hormone peptide YY (3-36) is a 36-amino acid peptide secreted from L-cells in the intestinal mucosa of the ileum and large intestine in proportion to caloric intake.

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CAT#10-101-96
CAS123583-37-9 (net)
Background

Peptide YY (PYY), a novel 36 amino-acid amidated hormone is a component of the complex neuroendocrine control process. This gut hormone (3-36), when infused into subjects, has been shown to reduce food intake in normal-weight and obese individuals. PYY (3-36) infusion also reduces the plasma levels of the hunger-promoting hormone ghrelin. PYY (3-36) levels have been shown to drop pre-meal and then increase post-prandially. In circulation, PYY (3-36) exists in at least two molecular forms: (1-36) and (3-36). PYY (3-36) selectively binds to Y2 receptors, and it has been found in human intestine and circulating blood.  >> Read More

Synonyms/AliasPYY (3-36); Peptide YY; C16118; PYY3-36
M.F/FormulaC180H279N53O54
M.W/Mr.4049.52
SequenceIle-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2
Labeling TargetNeuropeptide Y Receptor
ApplicationPYY (3-36) plays an important role in the regulation of appetite control. It is assumed that this effect is mediated through Y2 receptors in the hypothalamic arcuate nucleus (ARC), a brain area responsible for the regulation of food intake. PYY (3-36) may represent a promising tool for the treatment of obesity.
Areas of InterestMetabolic Disease
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