Ezatiostat

Name: Ezatiostat
Brand: Creative Peptides
SKU: HB00099
Availability: MadeToOrder

Ezatiostat (TER199 free base; TLK199) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat leads to JNK activation by inhibiting GSTP1. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat has the potential for myelodysplastic syndrome (MDS) treatment.

Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

CAT No: HB00099

CAS No: 168682-53-9

Synonyms/Alias: Ezatiostat;168682-53-9;Ezatiostat [INN];Terrapin 199;TLK-199;UNII-057D10I8S8;057D10I8S8;TLK199;Glycine, L-g-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-;ethyl (2S)-2-amino-5-[[(2R)-3-benzylsulfanyl-1-[[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate;DTXSID40168592;gamma-Glutamyl-S-(benzyl)-cysteinyl-R(-)-phenylglycine diethyl ester;ezatiotsat;TER 199;TLK 199;ethyl (2S)-2-amino-4-{[(1R)-2-(benzylsulfanyl)-1-{[(1R)-2-ethoxy-2-oxo-1-phenylethyl]carbamoyl}ethyl]carbamoyl}butanoate;Glycine, L-gamma-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-, diethyl ester, (2R)-;Glycine, N-(N-L-gamma-glutamyl-S-(phenylmethyl)-L-cysteinyl)-D-2-phenyl-, diethyl ester;TLK 117;ETHYL (2R)-((4S)-4-AMINO-5-ETHOXY-5-OXOPENTANOYL)-S-BENZYL-L-CYSTEINYL-2-PHENYLGLYCINATE;Ethyl N5-((R)-3-(benzylthio)-1-(((R)-2-ethoxy-2-oxo-1-phenylethyl)amino)-1-oxopropan-2-yl)-L-glutaminate;GLYCINE, L-.GAMMA.-GLUTAMYL-S-(PHENYLMETHYL)-L-CYSTEINYL-2-PHENYL-, DIETHYL ESTER, (2R)-;T.199;ezatiostatum;ethyl (2S)-2-amino-4-(((1R)-2-(benzylsulfanyl)-1-(((1R)-2-ethoxy-2-oxo-1-phenylethyl)carbamoyl)ethyl)carbamoyl)butanoate;gamma-glutamyl-S-(benzyl)cysteinyl-phenylglycine diethyl ester;MFCD27982957;SCHEMBL420400;CHEMBL2110585;DTXCID8091083;EX-A345;HY-13634A;NSC758484;AKOS005266721;CS-1713;DB05460;NSC-758484;NCGC00263221-01;NCGC00263221-05;AS-74082;DA-63345;NS00072776;BRD-K98963219-001-01-2;Q27095680;(2R)-L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-glycine Diethyl Ester; N-[N-L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl]-D-2-phenyl-glycine Diethyl Ester; Ter 199; Terrapin 199;

Quick Inquiry Custom Peptide Synthesis

Thymosin β4 Acetate

Thymosin β4 is a 43 amino acid peptide which is regarded as the main intracellular G-actin sequestering peptide. Extracellular thymosin β4 may contribute to physiological processes such as angiogenesis, wound healing and regulation of inflammation.

Inquiry
Deslorelin Acetate

Deslorelin acetate is an injectable gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (testosterone and oestrogen).

Inquiry
Buserelin Acetate

Buserelin Acetate is an agonist of gonadotropin-releasing hormone receptor(GnRHR). Buserelin is a synthetic luteinizing hormone–releasing hormone (LHRH) analog.

Inquiry
Thymopentin Acetate

Thymopentin, also known as TP-5, is a synthetic derivative of thymopoietin, a thymic hormone, and has immunoregulatory properties. Thymopentin interacts with T cells, reduces endocrine and behavioral responses to experimental stress. It is also found to increase the number of cells undergoing apoptosis in irradiated cells and selectively bind to apoptotic cells.

Inquiry
Teduglutide

Teduglutide is a polypeptide consisting of 33 amino acids. It is glucagon-like peptide-2 (GLP-2) analogue that is used for the treatment of short bowel syndrome.

Inquiry
Lanreotide Acetate

Lanreotide is a a synthetic cyclic octapeptide analogue of somatostatin. Lanreotide inhibits the secretion of growth hormone (GH) by binding to pituitary somatostatin receptors, and may inhibit the release of various other hormones, including thyroid stimulating hormone (TSH) and the gastroenteropancreatic hormones insulin, glucagon and gastrin.

Inquiry
Gonadorelin Acetate

Gonadorelin is a trophic peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released from GnRH neurons within the hypothalamus. The peptide belongs to gonadotropin-releasing hormone family. It constitutes the initial step in the hypothalamic–pituitary–gonadal axis.

Inquiry
Terlipressin

Terlipressin is a synthetic triglycyllysine derivative of vasopressin with vasoconstrictive, antihemorrhagic, and antidiuretic properties. Upon intravenous administration, terlipressin, an inactive prodrug, is biotransformed to its active moiety, lysine vasopressin (LVP), a nonselective vasopressin analogue with affinity for vasopressin receptors V1 (V1a), V2 and V3 (V1b). As a V1 agonist, terlipressin increases systemic vascular resistance, particularly in the splanchnic area, resulting in a decrease of portal pressure. V1 binding also promotes platelet aggregation and glycogenolysis, while V3 binding induces adrenocorticotropic hormone (ACTH) secretion. Compared to vasopressin, terlipressin has a minimal effect on V2 receptors, which are responsible for promotion of water reabsorption in the collecting ducts of the kidney via stimulation of cyclic AMP production.

Inquiry
Deslorelin

Deslorelin is a gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (testosterone and oestrogen). It is currently approved for use in veterinary medicine and is used to induce ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock. Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland.

Inquiry
Argipressin

Vasopressin, also known as arginine vasopressin (AVP), antidiuretic hormone (ADH), or argipressin, is a neurohypophysial hormone found in most mammals. Its two primary functions are to retain water in the body and to constrict blood vessels.

Inquiry

M.F/Formula	C27H35N3O6S
M.W/Mr.	529.6
Sequence	Three Letter Code:H-gGlu(OEt)-Cys(Bn)-D-Phg-OEt
Activity	Inhibitor
Target	Gutathione S-transferase

Shipping Condition	Room temperature in continental US; may vary elsewhere.
InChI	InChI=1S/C27H35N3O6S/c1-3-35-26(33)21(28)15-16-23(31)29-22(18-37-17-19-11-7-5-8-12-19)25(32)30-24(27(34)36-4-2)20-13-9-6-10-14-20/h5-14,21-22,24H,3-4,15-18,28H2,1-2H3,(H,29,31)(H,30,32)/t21-,22-,24+/m0/s1
InChI Key	GWEJFLVSOGNLSS-WPFOTENUSA-N