Ezatiostat

Name: Ezatiostat
Brand: Creative Peptides
SKU: HB00099
Availability: MadeToOrder

Ezatiostat (TER199 free base; TLK199) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat leads to JNK activation by inhibiting GSTP1. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat has the potential for myelodysplastic syndrome (MDS) treatment.

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CAT No: HB00099

CAS No: 168682-53-9

Synonyms/Alias: Ezatiostat;168682-53-9;Ezatiostat [INN];Terrapin 199;TLK-199;UNII-057D10I8S8;057D10I8S8;TLK199;Glycine, L-g-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-;ethyl (2S)-2-amino-5-[[(2R)-3-benzylsulfanyl-1-[[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate;DTXSID40168592;gamma-Glutamyl-S-(benzyl)-cysteinyl-R(-)-phenylglycine diethyl ester;ezatiotsat;TER 199;TLK 199;ethyl (2S)-2-amino-4-{[(1R)-2-(benzylsulfanyl)-1-{[(1R)-2-ethoxy-2-oxo-1-phenylethyl]carbamoyl}ethyl]carbamoyl}butanoate;Glycine, L-gamma-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-, diethyl ester, (2R)-;Glycine, N-(N-L-gamma-glutamyl-S-(phenylmethyl)-L-cysteinyl)-D-2-phenyl-, diethyl ester;TLK 117;ETHYL (2R)-((4S)-4-AMINO-5-ETHOXY-5-OXOPENTANOYL)-S-BENZYL-L-CYSTEINYL-2-PHENYLGLYCINATE;Ethyl N5-((R)-3-(benzylthio)-1-(((R)-2-ethoxy-2-oxo-1-phenylethyl)amino)-1-oxopropan-2-yl)-L-glutaminate;GLYCINE, L-.GAMMA.-GLUTAMYL-S-(PHENYLMETHYL)-L-CYSTEINYL-2-PHENYL-, DIETHYL ESTER, (2R)-;T.199;ezatiostatum;ethyl (2S)-2-amino-4-(((1R)-2-(benzylsulfanyl)-1-(((1R)-2-ethoxy-2-oxo-1-phenylethyl)carbamoyl)ethyl)carbamoyl)butanoate;gamma-glutamyl-S-(benzyl)cysteinyl-phenylglycine diethyl ester;MFCD27982957;SCHEMBL420400;CHEMBL2110585;DTXCID8091083;EX-A345;HY-13634A;NSC758484;AKOS005266721;CS-1713;DB05460;NSC-758484;NCGC00263221-01;NCGC00263221-05;AS-74082;DA-63345;NS00072776;BRD-K98963219-001-01-2;Q27095680;(2R)-L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-glycine Diethyl Ester; N-[N-L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl]-D-2-phenyl-glycine Diethyl Ester; Ter 199; Terrapin 199;

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M.F/Formula	C27H35N3O6S
M.W/Mr.	529.6
Sequence	Three Letter Code:H-gGlu(OEt)-Cys(Bn)-D-Phg-OEt
Activity	Inhibitor
Target	Gutathione S-transferase

Shipping Condition	Room temperature in continental US; may vary elsewhere.
InChI	InChI=1S/C27H35N3O6S/c1-3-35-26(33)21(28)15-16-23(31)29-22(18-37-17-19-11-7-5-8-12-19)25(32)30-24(27(34)36-4-2)20-13-9-6-10-14-20/h5-14,21-22,24H,3-4,15-18,28H2,1-2H3,(H,29,31)(H,30,32)/t21-,22-,24+/m0/s1
InChI Key	GWEJFLVSOGNLSS-WPFOTENUSA-N