VKGILS-NH2 is a reversed amino acid sequence control peptide for SLIGKV-NH2 (protease-activated receptor 2 (PAR2) agonist). VKGILS-NH2 has no effect on DNA synthesis in cells.
CAT No: HB00101
CAS No:942413-05-0
Synonyms/Alias:VKGILS-NH2;942413-05-0;(2S)-6-amino-N-[2-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-2-[[(2S)-2-amino-3-methylbutanoyl]amino]hexanamide;VKGILS;VKGILS-NH2?;PAR-2 6-1 amide human;EX-A9090;AKOS024457600;FP109639;MS-30733;G13482;H-Val-Lys-Gly-Ile-Leu-Ser-NH2; H-VKGILS-NH2;PAR-2 (6-1) amide (human) trifluoroacetate salt;
PAR-2 (6-1) amide (human) is a synthetic peptide fragment derived from the protease-activated receptor 2 (PAR-2), a G protein-coupled receptor involved in diverse physiological and pathophysiological processes. This peptide is engineered to mimic a specific region of the human PAR-2 receptor, allowing precise interrogation of receptor activation, signaling pathways, and downstream biological effects in experimental settings. As a tool compound, it serves as a valuable resource for researchers investigating the molecular mechanisms of PAR-2-mediated cellular responses, particularly in the context of inflammation, pain, vascular biology, and epithelial function.
Receptor activation studies: Researchers utilize PAR-2 (6-1) amide as a selective agonist to probe the activation and functional consequences of PAR-2 signaling in various cell types. By applying this peptide to cultured cells or tissue preparations, it is possible to induce PAR-2-mediated responses in a controlled manner, enabling the dissection of downstream signaling cascades such as calcium mobilization, MAPK activation, and cytokine release. These studies are essential for elucidating the fundamental biology of PAR-2 and for distinguishing receptor-specific effects from those mediated by related protease-activated receptors.
Inflammation research: The peptide provides a robust experimental system for modeling pro-inflammatory processes mediated by PAR-2 activation. Investigators employ it to stimulate immune and non-immune cells, assessing the production of inflammatory mediators, chemokines, and adhesion molecules. This approach supports the exploration of PAR-2's role in the regulation of leukocyte recruitment, vascular permeability, and the amplification of inflammatory signaling, contributing to a deeper understanding of inflammatory diseases at the molecular level.
Pain and sensory signaling: Experimental models of nociception and sensory transduction benefit from the use of PAR-2 (6-1) amide to activate receptor pathways implicated in pain perception. By applying the peptide to neuronal or sensory tissue systems, researchers can evaluate changes in neuronal excitability, neurotransmitter release, and the modulation of ion channels. Such studies are instrumental in identifying mechanisms underlying hyperalgesia and allodynia, as well as in screening potential inhibitors of PAR-2-driven pain signaling.
Epithelial barrier function: The compound is frequently employed in studies examining epithelial integrity and barrier regulation, particularly in the gastrointestinal and respiratory tracts. Activation of PAR-2 by this peptide enables the investigation of tight junction dynamics, paracellular permeability, and the interplay between epithelial cells and their microenvironment. These models are vital for understanding how PAR-2 contributes to barrier dysfunction in conditions such as asthma, colitis, and other mucosal inflammatory disorders.
Pharmacological screening and assay development: PAR-2 (6-1) amide serves as a standard tool in the development and validation of bioassays designed to quantify receptor activation or inhibition. Its defined agonist properties facilitate the benchmarking of novel antagonists, allosteric modulators, or signaling pathway inhibitors in both high-throughput and mechanistic assay formats. By providing a reproducible means of receptor engagement, the peptide supports the advancement of pharmacological research focused on GPCR-targeted drug discovery and receptor biology.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More