Aclerastide is an angiotensin receptor agonist. It can reduce fibrosis and scarring in the healing wounds. This action is more pronounced with longer administration of the peptide after injury. The action of this peptide is blocked by the AT receptor antagonist d-Ala7-angiotensin(1-7), which suggests that this receptor is involved in the healing responses to exogenous NorLeu3-A(1-7). Aclerastide has the potential in accelerating wound repair and reducing scar formation.
CAT No: 10-101-183
CAS No:227803-63-6
Synonyms/Alias:Norleu3-a(1-7); UNII-YYD6UT8T47; Asp-arg-nle-tyr-ile-his-pro; DSC127; DSC-127; USB-001;
Aclerastide is a synthetic peptide compound recognized for its role in modulating tissue repair and cellular signaling pathways. Structurally designed to mimic specific bioactive sequences, it has garnered significant interest in biochemical research focused on wound healing and extracellular matrix interactions. Its unique peptide composition enables targeted investigation into the mechanisms of cell migration, proliferation, and tissue remodeling, making it a valuable tool for researchers studying peptide-mediated biological processes. As a research-use-only reagent, Aclerastide is particularly well-suited for experimental applications that require precise modulation of peptide-related pathways without confounding clinical or regulatory variables.
Peptide Mechanism Studies: In the context of mechanistic research, Aclerastide serves as a model peptide for dissecting the cellular and molecular events underlying tissue repair. Its ability to engage specific receptors and influence downstream signaling cascades allows scientists to map the effects of peptide ligands on cellular behavior. By employing this compound in in vitro assays, researchers can elucidate the pathways involved in fibroblast activation, matrix deposition, and the regulation of growth factors, contributing to a deeper understanding of peptide-driven tissue dynamics.
Cell Migration and Proliferation Assays: The peptide's functional properties make it an effective agent in studies of cell migration and proliferation, particularly in wound healing models. When introduced to cultured cell systems, it can be used to quantify migratory responses and proliferative capacity in keratinocytes, fibroblasts, or other relevant cell types. Such assays are critical for identifying molecular targets that control tissue regeneration and for validating the biological activity of novel peptide analogs or inhibitors.
Extracellular Matrix Interaction Research: Aclerastide's sequence allows for the investigation of peptide-extracellular matrix interactions, which are fundamental to tissue structure and function. Researchers utilize this compound to examine how peptides influence the assembly and remodeling of matrix proteins such as collagen and fibronectin. These studies provide insight into the biophysical and biochemical cues that govern cell-matrix adhesion, matrix turnover, and the overall integrity of tissue architecture.
Peptide Synthesis and Analytical Validation: The compound is also employed as a reference material in peptide synthesis and analytical method development. Its defined sequence and functional properties make it suitable for optimizing solid-phase peptide synthesis protocols and for calibrating analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry. Using Aclerastide as a standard supports quality control efforts and ensures reproducibility in peptide production and analysis workflows.
High-Content Screening for Peptide Modulators: In high-throughput screening platforms, Aclerastide can be incorporated to identify and characterize small molecules or biologics that modulate peptide-dependent pathways. By serving as a functional probe, it enables the systematic evaluation of compound libraries for their effects on peptide-mediated signaling, cell behavior, or matrix interactions. This approach accelerates the discovery of new research tools and potential modulators for further biochemical investigation.
Preclinical and clinical research shows that DSC127 is highly effective in the closure of diabetic wounds and is superior to Regranex in animal studies. Clinical development of DSC127 as a topical agent for the healing of DFU is underway. Further investigation into the mechanisms by which this product accelerates healing is warranted.
NorLeu3-Angiotensin (1-7) [DSC127] as a Therapy for the Healing of Diabetic Foot Ulcers
Derma Sciences, a tissue regeneration company focused on advanced wound and burn care, announced the termination of its Phase III clinical trials with aclerastide (DSC 127) for diabetic foot ulcer healing. This action is based on futility determinations conducted by the Data Monitoring Committee (DMC) for the planned, pre-specified interim analyses regarding the primary efficacy endpoint of confirmed complete wound closure of the target ulcer within 12 weeks of the start of treatment.
DSC 127 (aclerastide) fails diabetic foot ulcer healing trial and programme is cancelled- Derma Sciences Inc.
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