Aclerastide

Aclerastide is an angiotensin receptor agonist. It can reduce fibrosis and scarring in the healing wounds. This action is more pronounced with longer administration of the peptide after injury. The action of this peptide is blocked by the AT receptor antagonist d-Ala7-angiotensin(1-7), which suggests that this receptor is involved in the healing responses to exogenous NorLeu3-A(1-7). Aclerastide has the potential in accelerating wound repair and reducing scar formation.

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CAT#10-101-183
CAS227803-63-6
Synonyms/AliasNorleu3-a(1-7); UNII-YYD6UT8T47; Asp-arg-nle-tyr-ile-his-pro; DSC127; DSC-127; USB-001;
M.F/FormulaC42-H64-N12-O11
M.W/Mr.913.0406
SequenceH-Asp-Arg-Nle-Tyr-Ile-His-Pro-OH
Labeling TargetAngiotensin receptor
ApplicationAclerastide is studied for the treatment of Diabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabetic.
AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
ActivityAgonist
Biological ActivityAclerastide, also known as DSC-127; NorLeu-3-A(1-7); NorLeu-3A(1-7), is an angiotensin receptor agonist potentially for the treatment of tissue regeneration in diabetic ulcers.
DiseaseDiabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabeti
TargetAngiotensin Receptor
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