Aclerastide

Name: Aclerastide
Brand: Creative Peptides
SKU: 10-101-183
Availability: MadeToOrder

Aclerastide is an angiotensin receptor agonist. It can reduce fibrosis and scarring in the healing wounds. This action is more pronounced with longer administration of the peptide after injury. The action of this peptide is blocked by the AT receptor antagonist d-Ala7-angiotensin(1-7), which suggests that this receptor is involved in the healing responses to exogenous NorLeu3-A(1-7). Aclerastide has the potential in accelerating wound repair and reducing scar formation.

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CAT No: 10-101-183

CAS No: 227803-63-6

Synonyms/Alias: Norleu3-a(1-7); UNII-YYD6UT8T47; Asp-arg-nle-tyr-ile-his-pro; DSC127; DSC-127; USB-001;

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Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C42-H64-N12-O11
M.W/Mr.	913.0406
Sequence	H-Asp-Arg-Nle-Tyr-Ile-His-Pro-OH
Labeling Target	Angiotensin receptor
Application	Aclerastide is studied for the treatment of Diabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabetic.
Appearance	Solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Activity	Agonist
Biological Activity	Aclerastide, also known as DSC-127; NorLeu-3-A(1-7); NorLeu-3A(1-7), is an angiotensin receptor agonist potentially for the treatment of tissue regeneration in diabetic ulcers.
Areas of Interest	Diabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabeti
Target	Angiotensin Receptor

Source#	Synthetic
Long-term Storage Conditions	Soluble in DMSO
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions	Dry, dark and at 0 - 4 °C
Solubility	-20 °C
ShelfLife	>2 years if stored properly
References	Preclinical and clinical research shows that DSC127 is highly effective in the closure of diabetic wounds and is superior to Regranex in animal studies. Clinical development of DSC127 as a topical agent for the healing of DFU is underway. Further investigation into the mechanisms by which this product accelerates healing is warranted. NorLeu3-Angiotensin (1-7) [DSC127] as a Therapy for the Healing of Diabetic Foot Ulcers Derma Sciences, a tissue regeneration company focused on advanced wound and burn care, announced the termination of its Phase III clinical trials with aclerastide (DSC 127) for diabetic foot ulcer healing. This action is based on futility determinations conducted by the Data Monitoring Committee (DMC) for the planned, pre-specified interim analyses regarding the primary efficacy endpoint of confirmed complete wound closure of the target ulcer within 12 weeks of the start of treatment. DSC 127 (aclerastide) fails diabetic foot ulcer healing trial and programme is cancelled- Derma Sciences Inc.

1. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die

2. Spatiotemporal delivery of nanoformulated liraglutide for cardiac regeneration after myocardial infarction

3. Novel Peptide-Based PD1 Immunomodulators Demonstrate Efficacy in Infectious Disease Vaccines and Therapeutics

4. The effect of B-type allatostatin neuropeptides on crosstalk between the insect immune response and cold tolerance

5. Multifunctional peptide-oligonucleotide conjugate promoted sensitive electrochemical biosensing of cardiac troponin I

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