Aclerastide
Aclerastide is an angiotensin receptor agonist. It can reduce fibrosis and scarring in the healing wounds. This action is more pronounced with longer administration of the peptide after injury. The action of this peptide is blocked by the AT receptor antagonist d-Ala7-angiotensin(1-7), which suggests that this receptor is involved in the healing responses to exogenous NorLeu3-A(1-7). Aclerastide has the potential in accelerating wound repair and reducing scar formation.
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| CAT# | 10-101-183 |
| CAS | 227803-63-6 |
| Synonyms/Alias | Norleu3-a(1-7); UNII-YYD6UT8T47; Asp-arg-nle-tyr-ile-his-pro; DSC127; DSC-127; USB-001; |
| M.F/Formula | C42-H64-N12-O11 |
| M.W/Mr. | 913.0406 |
| Sequence | H-Asp-Arg-Nle-Tyr-Ile-His-Pro-OH |
| Labeling Target | Angiotensin receptor |
| Application | Aclerastide is studied for the treatment of Diabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabetic. |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Activity | Agonist |
| Biological Activity | Aclerastide, also known as DSC-127; NorLeu-3-A(1-7); NorLeu-3A(1-7), is an angiotensin receptor agonist potentially for the treatment of tissue regeneration in diabetic ulcers. |
| Disease | Diabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabeti |
| Target | Angiotensin Receptor |
| Source# | Synthetic |
Storage | -20°C |
Solubility | Soluble in DMSO |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Short-term Storage Conditions | Dry, dark and at 0 - 4 °C |
Long-term Storage Conditions | -20 °C |
ShelfLife | >2 years if stored properly |
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