β-casomorphin, bovine (β-casomorphin-7) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay.
CAT No: 10-101-280
CAS No:72122-62-4
Synonyms/Alias:72122-62-4;beta-casomorphin 7;beta-Casomorphin (bovine);Tyr-pro-phe-pro-gly-pro-ile;Beta-casomorphine-7;beta-Casomorphin, bovine;Tyrosyl-prolyl-phenylalanyl-prolylglycyl-prolyl-isoleucine;(2S,3S)-2-[[(2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoic acid;CHEMBL2370605;l-tyrosyl-l-prolyl-l-phenylalanyl-l-prolylglycyl-l-prolyl-l-isoleucine;L-Isoleucine, N-(1-(N-(1-(N-(1-L-tyrosyl-L-prolyl)-L-phenylalanyl)-L-prolyl)glycyl)-L-prolyl)-;Beta Casomorphin;beta-Casomorphin-7 (bovine);-Casomorphin, bovine;beta-Casomorphin bovine;BETA-CASOMORPHIN(BOVINE);SCHEMBL22413056;DTXSID10992846;HY-P0179;BDBM50089072;DA-79181;FC108651;CS-0021096;-Casomorphin-7 (bovine);Bovine -casomorphin-7;(2S,3S)-2-((S)-1-(2-((S)-1-((S)-2-((S)-1-((S)-2-amino-3-(4-hydroxyphenyl)propanoyl)pyrrolidine-2-carboxamido)-3-phenylpropanoyl)pyrrolidine-2-carboxamido)acetyl)pyrrolidine-2-carboxamido)-3-methylpentanoic acid;(2S,3S)-2-{[(2S)-1-(2-{[(2S)-1-[(2S)-2-{[(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoyl]pyrrolidin-2-yl]formamido}acetyl)pyrrolidin-2-yl]formamido}-3-methylpentanoic acid;2-({1-[2-({1-[2-({1-[2-Amino-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-acetyl]-pyrrolidine-2-carbonyl}-amino)-3-methyl-pentanoic acid;N-[Hydroxy(1-{N-[hydroxy(1-{N-[hydroxy(1-tyrosylpyrrolidin-2-yl)methylidene]phenylalanyl}pyrrolidin-2-yl)methylidene]glycyl}pyrrolidin-2-yl)methylidene]isoleucine;
β-Casomorphin (1-7), bovine, is a naturally occurring peptide fragment derived from the enzymatic digestion of bovine milk casein. As a member of the opioid peptide family, it exhibits unique biochemical properties, notably its affinity for opioid receptors and its resistance to rapid enzymatic degradation. The sequence of seven amino acids confers upon it a distinct profile, allowing researchers to explore its physiological and biochemical roles across various scientific domains. Its ability to interact with specific cellular targets has made it a valuable tool in studies investigating the complex interplay between dietary proteins and biological systems. The versatility of β-Casomorphin (1-7), bovine, has led to its adoption in a range of experimental applications, where it serves as both a model compound and a functional probe for advancing our understanding of peptide-mediated processes.
Neuroscience research: β-Casomorphin (1-7), bovine, is extensively utilized in neuroscience to examine the modulation of neuronal signaling by food-derived opioid peptides. By binding to opioid receptors, it enables researchers to dissect the pathways involved in neurotransmitter release, synaptic plasticity, and neural circuit regulation. Studies employing this peptide help clarify the mechanisms by which exogenous peptides influence brain function, particularly in relation to reward, mood, and cognitive processes. Its use in in vitro and in vivo models provides valuable insights into the neurochemical consequences of dietary protein metabolism, contributing to a more nuanced understanding of the gut-brain axis.
Gastrointestinal physiology: In research focused on gastrointestinal function, β-Casomorphin (1-7), bovine, serves as a model compound for investigating how dietary peptides interact with the enteric nervous system and epithelial cells. Its opioid activity has been implicated in modulating gastrointestinal motility, secretion, and absorption, making it a subject of interest for studies on digestive health and peptide transport mechanisms. By employing this peptide in experimental systems, scientists can elucidate the effects of casein-derived peptides on gut physiology, including their impact on intestinal barrier function and local immune responses.
Nutritional science: The study of β-Casomorphin (1-7), bovine, has advanced the field of nutritional science by providing a molecular link between dietary proteins and physiological responses. Researchers use it to explore how milk-derived peptides influence satiety, food intake regulation, and metabolic signaling pathways. Its application in nutritional models helps clarify the role of bioactive peptides in shaping dietary behaviors and metabolic outcomes, offering a molecular perspective on the impact of milk consumption on human health.
Immunology and inflammation: β-Casomorphin (1-7), bovine, is also investigated for its potential effects on immune cell activity and inflammatory processes. By interacting with opioid receptors expressed on immune cells, it offers a means to study the modulation of cytokine production, cell migration, and immune signaling pathways. These studies contribute to a deeper understanding of the crosstalk between dietary components and the immune system, highlighting the broader significance of food-derived peptides in immune regulation.
Peptide transport and enzymology: Researchers utilize β-Casomorphin (1-7), bovine, as a substrate to probe the specificity and kinetics of peptide transporters and peptidases in biological membranes. Its defined structure and resistance to rapid degradation make it an ideal candidate for studying the absorption and metabolism of bioactive peptides. By tracking its transport and enzymatic breakdown, scientists gain valuable data on the mechanisms governing peptide bioavailability, stability, and cellular uptake, which are crucial for the development of functional foods and nutraceuticals.
The broad research applications of β-Casomorphin (1-7), bovine, underscore its importance as a tool for advancing scientific knowledge across multiple disciplines. Its unique properties facilitate in-depth exploration of opioid receptor biology, digestive physiology, nutritional biochemistry, immune modulation, and peptide transport dynamics. As interest in food-derived bioactive compounds grows, the continued use of this peptide in experimental settings will provide crucial insights into the molecular mechanisms underpinning the interactions between diet and health, further supporting innovation in both basic and applied life sciences.
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