Peginesatide
Peginesatide is a synthetic peptide attached to polyethylene glycol for the treatment of anemia. The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. Chemically, peginesatide is designed to mimic the pharmacological activity of erythropoietin, but is not a replica of the structure itself. Peginesatide consists of two 21-amino acid chains that are covalently bonded by a linker derived from iminodiacetic acid and β-alanine.
Online Inquiry
| CAT# | 10-101-162 |
| CAS | 913976-27-9, 910576-32-8 |
| Background | Peginesatide is a synthetic peptide attached to polyethylene glycol for the treatment of anemia. The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. Chemically, peginesatide is designed to mimic the pharmacological activity of erythropoietin, but is not a replica of the structure itself. Peginesatide is a peptide-based erythropoiesis-stimulating agent (ESA) that may have therapeutic potential for anemia in patients with advanced chronic kidney disease. We evaluated the safety and efficacy of peginesatide, as compared with another ESA, darbepoetin, in 983 such patients who were not undergoing dialysis.Peginesatide consists of two 21-amino acid chains that are covalently bonded by a linker derived from iminodiacetic acid and β-alanine. >> Read More |
| Synonyms/Alias | AF37702;AF 37702;Hematide;HSDB 8181;Peginesatide;UNII-JX56W9N61Q |
| M.F/Formula | C233H352N62O60S6 |
| M.W/Mr. | 5174.06 |
| Labeling Target | Erythropoietin receptor |
| Application | Treatment of anemia associated with chronic kidney disease |
| Activity | Stimulator |
| Biological Activity | Peginesatide is a synthetic peptide attached to polyethylene glycol for the treatment of anemia. The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. |
| Areas of Interest | Chronic kidney disease |
| Functions | Identical protein binding |
| Source# | Synthetic |
Storage | -20°C |
Organism | Human |
References | Peginesatide is a peptide-based erythropoiesis-stimulating agent (ESA) that may have therapeutic potential for anemia in patients with advanced chronic kidney disease. We evaluated the safety and efficacy of peginesatide, as compared with another ESA, darbepoetin, in 983 such patients who were not undergoing dialysis. Peginesatide for Anemia in Patients with Chronic Kidney Disease Not Receiving Dialysis Peginesatide, a synthetic peptide-based erythropoiesis-stimulating agent (ESA), is a potential therapy for anemia in patients with advanced chronic kidney disease. Peginesatide, administered monthly, was as effective as epoetin, administered one to three times per week, in maintaining hemoglobin levels in patients undergoing hemodialysis. Peginesatide in Patients with Anemia Undergoing Hemodialysis |
Write a review
Ask a question
My Review for Peginesatide
Required fields are marked with *
×
Ask a Question for Peginesatide
Required fields are marked with *
×
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
