D Amino Acid Peptide Synthesis Service

* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

Online Inquiry

According to the central dogma established by classical naturalists and biologists, proteins/peptides were expected to be exclusively constituted by 20 building blocks, including 19 L-amino acids (L-AAs) and glycine, which is not chiral. At that time, special cases were reported for D-amino acids (D-AAs) containing proteins/peptides such as the presence of D-alanine in octopine derivatives from octopus.

From a functional point of view, these post-translational and chemical modifications in D-AAs containing proteins/peptides confer on them an unusual stereochemistry mostly related to enhanced resistance to enzyme-catalyzed breakdown.

It is worth mentioning the composition of retro-inverso (RI) peptides, also known as all-D-retro peptides or retro-enantio peptides, which are composed of D-AAs assembled in the reverse order to that of their parent L-sequence.

Representation of the planar structure and chirality of hypothetic L-, diastereomeric, all-D- and RI-peptides, also highlighting their pros and cons. Representation of the planar structure and chirality of hypothetic L-, diastereomeric, all-D- and RI-peptides, also highlighting their pros and cons.

Figure 1 Representation of the planar structure and chirality of hypothetic L-, diastereomeric, all-D- and RI-peptides, also highlighting their pros and cons.

Advantages of retro-inverso peptides:

General applications of D-AAs containing peptides

Reference

  1. Marlon H. Cardoso, Elizabete S. Candido. (2017). Peptides containing and retro-inverso peptides: D-amino acids General applications and special focus on antimicrobial peptides.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.

Customer Support & Price Inquiry

Resource

Creative Peptides is a custom lab chemical supplier that provides a wide range of peptides for the pharmaceutical and biotechnology industries.

Learn More

PAC-113: A clinically active antimicrobial peptide

 PAC-113, as well as a new type of Trp-rich peptide, is a 12 amino-acid fragment of the saliva protein histatin 5 ...

MC1R antagonist-MSG 606

 MSG 606 (Cyclo-[(CH2) 3CO-Gly-His-D-Phe-Arg-D-Trp-Cys(S-)]-Asp-Arg-Phe-Gly-NH2) is a potent and novel cyclic thi ...

Function of elcatonin in treatment of osteoporosis

 Elcatonin acetate, a physicochemically and biologically stable synthetic derivative of calcitonin transformed fr ...

The efficacy of teicoplanin in the treatment of Gram-positive cocci infection

 Teicoplanin is a glycopeptide antibiotic developed after vancomycin for the treatment of Gram-positive (G+) cocc ...

Function of linaclotide in irritable bowel syndrome

 Linaclotide, sold under the brand name Linzess, is a synthetic tetradecapeptide and guanylate cyclase (GC-C) rec ...

Contact Us

Address:

Tel: |

Email:

Copyright © 2022 Creative Peptides. All rights reserved.