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CAT# | Product Name | M.W | Molecular Formula | Inquiry |
---|---|---|---|---|
A14001 | Angiogenin (108-122) | 1781.01 | C78H125N25O23 | Inquiry |
A14002 | Angiogenin (108-123) | 1878.12 | C83H132N26O24 | Inquiry |
A14003 | rec Angiogenin (human) | Inquiry |
Angiogenin is a group of secreted cytokines that play an important role in revascularization, embryonic vascular, and cancer. There are four members in the family of angiogenin: Ang-1, Ang-2, Ang-3 and Ang-4, which have different functions in biological processes. Ang-1 inhibits endothelial cell apoptosis and promotes endothelial cell survival by activating its receptor tyrosine kinase Tie-2. The amino acid composition of Ang-1 and Ang-2 is partly identical and has a similar structure. Ang-2 participates in angiogenesis, remodeling and endometrial destabilization. The structure of Ang-3 cloned from mouse and Ang-4 cloned from human differed greatly from Ang-1 and Ang-2. Functionally, Ang-3 is similar to Ang-2, which acts as an antagonist. Agn-4 is similar to Ang-1, which acts as an activator.
Ang-1 and Ang-2 are involved in the development of embryo. In the first 3 months of the embryonic placenta, Ang-1, Ang-2 and Tie-2 are located in the trophoblast and exert function by autocrine. Ang-2 stimulates the synthesis of trophoblast DNA. Agn-1 acts as a potent chemotactic factor in the trophoblast. Agn-1 is mainly expressed in stromal cells surrounding the main trunk of villus, maintaining and promoting maternal blood vessels stable and mature in late pregnancy. Ang-2 is expressed in all villous stromal cells. Accumulating evidence suggests that angiogenin is closely associated with the formation of embryonic heart and vessels.
High expression of Ang-2 was found in many tumor blood vessels such as colon cancer and non-small cell lung cancer. Ang-2 can be used as an early marker of tumor cell infiltration of blood vessels. Therefore, it has a certain application prospect in predicting small tumor metastasis and pathological imaging analysis. Additionally, Ang-1 contributes to the stabilization of vascular endothelial cells, preventing anti-inflammatory effects like leakage. Ang-1 also has certain therapeutic effect on blood deficiency diseases, which can indirectly increase the number of new blood vessels.
References
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