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Linear Peptide Synthesis

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

Reproducible peptide qualityDifficult-sequence peptide synthesisBatch-to-batch consistency

We provide high-quality custom linear peptide synthesis services designed for enterprise R&D teams, academic laboratories, and pharmaceutical companies that require precise, reliable, and reproducible peptide products. Utilizing advanced solid-phase peptide synthesis (SPPS) technologies, rigorous purification workflows, and comprehensive analytical validation, we deliver tailor-made linear peptides that meet the demanding standards of modern biological research, diagnostic development, and early-stage drug discovery. From simple short peptides to complex long sequences and specialized modifications, our platform ensures exceptional purity, structural accuracy, and consistent batch performance.

What Problems Our Linear Peptide Synthesis Solves

Our service is engineered to address key challenges commonly faced in peptide-based research and industrial applications:

Application of Linear Peptide Synthesis

  • Challenges synthesizing complex, hydrophobic, or low-solubility sequences: We apply optimized synthesis strategies, resin selection, and coupling conditions to reliably produce sequences that conventional approaches often fail to deliver.
  • Unstable quality or inconsistent peptide purity: High-resolution HPLC purification and LC-MS characterization ensure reproducible purity, structural integrity, and dependable biological activity.
  • Limited in-house synthesis capability or resource constraints: We offer a cost-efficient, high-throughput alternative to internal peptide production—removing the need for specialized equipment, trained chemists, and extensive troubleshooting.
  • Delays in R&D timelines caused by slow peptide delivery: Our streamlined manufacturing workflow enables rapid turnaround while maintaining stringent quality standards, reducing experimental downtime.
  • Need for advanced modifications for functional, analytical, or therapeutic applications: We support a wide range of chemical modifications that expand peptide functionality—essential for mechanism studies, assay development, or preclinical research.

Specific Services We Provide

We deliver a comprehensive suite of high-precision peptide synthesis solutions designed to meet the rigorous standards of academic research, biotechnology development, and pharmaceutical innovation.

Custom Linear Peptide Synthesis (3-120+aa)

We provide high-precision synthesis of linear peptides across a wide range of sequence lengths and complexities, featuring:

  • Advanced SPPS-based synthesis ensuring accurate amino acid assembly and high sequence fidelity
  • High success rates for challenging sequences, including hydrophobic regions, repeats, and long-chain peptides
  • Flexible purity grades (crude, >70%, >85%, >95%, ≥98%) tailored to your application needs
  • Batch-to-batch consistency supported by optimized synthesis and purification protocols
  • Optional large-scale production, enabling seamless transition from discovery to development

Sequence Evaluation & Scientific Consultation

Our scientific team conducts a comprehensive pre-synthesis assessment to ensure optimal results, including:

  • Feasibility analysis for sequence complexity, structural motifs, and chemical stability
  • Evaluation of physicochemical properties, such as hydrophobicity, charge distribution, and aggregation risk
  • Solubility prediction and optimization recommendations to improve downstream handling
  • Modification compatibility assessment for labels, PTMs, linkers, or conjugates
  • Actionable synthesis strategy suggestions to enhance yield, purity, and performance in assays

Advanced Chemical Modifications

To support a wide range of research and therapeutic applications, we offer an extensive catalog of chemical modifications, including:

  • N-/C-terminal protection and functionalization (acetylation, amidation, etc.)
  • Fluorescent dye labeling (FAM, FITC, Cy3/Cy5, TAMRA)
  • Affinity tags and conjugation (biotin, linkers, carrier proteins)
  • Post-translational modification mimics (phosphorylation, methylation, glycosylation)
  • Structural modifications (disulfide bridges, cyclization precursors)
  • Stability enhancement (PEGylation, lipidation, stapling strategies)
  • Isotope labeling for proteomics, MS quantification, and structural studies

All modifications undergo rigorous validation to ensure structural accuracy and functional integrity.

Purification & Quality Control

Our multi-step purification and analytical system ensures the reliability required for high-impact scientific and pharmaceutical work. We provide:

  • Preparative HPLC purification tailored to your desired purity level
  • LC-MS identity confirmation with detailed chromatograms
  • Quantitative purity assessment and impurity profiling
  • Optional endotoxin testing, peptide solubility evaluation, and stability analysis

Every order is delivered with a full Certificate of Analysis (COA) for absolute transparency and data confidence.

Packaging, Aliquoting & Delivery

We ensure secure, stable, and convenient delivery of every peptide product through:

  • Lyophilized powder format for extended shelf life and improved stability
  • Sterile, airtight vials designed for research, analytical, and preclinical applications
  • Custom aliquoting options to reduce freeze-thaw cycles for sensitive sequences
  • Clear reconstitution guidelines for optimal solubility and experimental compatibility
  • Temperature-controlled shipment to maintain product integrity throughout transit

Scale-Up Options for Industry Clients

For biotech and pharmaceutical partners, we provide scalable synthesis models, including:

  • mg to gram-scale production
  • Process optimization for complex or long peptide sequences
  • Early development support for peptides progressing toward preclinical studies
  • GMP-ready workflows available upon request

Why Partner with Us?

Expert-Led Synthesis

Every project is executed by experienced peptide chemists using optimized SPPS strategies.

Uncompromising Quality

HPLC purification, LC-MS validation, and full COA documentation included with every batch.

Complex Projects Welcome

Hydrophobic, long, or difficult sequences handled with tailored synthesis solutions.

Industry-Ready Options

From milligram research quantities to gram-scale manufacturing and GMP-compatible workflows.

Consistent, Reproducible Results

Reliable peptide performance to support critical experiments and data integrity.

Fast & Predictable Delivery

Reduce project delays with efficient, streamlined production timelines.

How Our Linear Peptide Synthesis Service Works

1

Project Submission & Requirement Assessment

  • Submit your peptide sequence or project outline
  • Define purity level, quantity, modifications, and analytical requirements
  • Our team evaluates sequence complexity and synthesis feasibility

2

Scientific Consultation & Optimization

  • Detailed analysis of hydrophobicity, charge, and aggregation potential
  • Recommendations for solubility improvement or sequence adjustments
  • Confirmation of modification compatibility and structural integrity

3

Custom Synthesis (SPPS-Based Production)

  • Stepwise solid-phase peptide synthesis for precise chain assembly
  • Optimized coupling and deprotection cycles for difficult sequences
  • Specialized handling of long peptides, hydrophobic regions, and PTM-mimics

4

Purification & Analytical Quality Control

  • Preparative HPLC purification to desired purity grade
  • LC-MS identity confirmation and impurity profiling
  • Optional endotoxin testing, stability analysis, and functional evaluation

5

Lyophilization & Packaging

  • Freeze-drying to ensure long-term stability
  • Packaging into sterile, airtight vials
  • Optional aliquoting to prevent repeated freeze-thaw cycles

6

Documentation & Delivery

  • Complete COA, chromatograms, and MS data included
  • Temperature-controlled shipping to preserve peptide integrity
  • Post-delivery technical support for reconstitution and experimental use

Where Linear Peptides Are Used

Immunology & Vaccine Research

  • Antigen peptide design for antibody production
  • Epitope mapping for immune response characterization
  • T-cell epitope screening and functional assays
  • Peptide-based vaccine candidate evaluation
  • Immune recognition and MHC-binding studies

Drug Discovery & Therapeutic Development

  • Screening peptides as early-stage drug leads
  • Target binding assays and mechanism-of-action studies
  • Inhibitor/agonist design for protein-protein interactions
  • Peptide fragments for structure-activity relationship (SAR) analysis
  • Engineered therapeutic peptide precursor evaluation

Proteomics & Mass Spectrometry

  • Stable isotope-labeled peptides for quantitative proteomics
  • Internal standards for LC-MS/MS method development
  • Sequence-specific peptides for biomarker validation
  • Calibration peptides for instrument performance verification
  • Reference peptides for targeted proteomic assays

Molecular Biology & Biochemical Research

  • Substrate peptides for enzymatic activity assays
  • Phosphorylated or methylated sequences for signaling pathway studies
  • Peptides for protein folding, binding, or stability experiments
  • Custom motifs for receptor-ligand interaction analysis
  • Peptide probes for pathway mapping or inhibitor profiling

Diagnostic Development & Analytical Assays

  • Synthetic peptides for ELISA, Western blot, and immunoassays
  • Calibration standards for clinical testing platforms
  • Peptide controls for assay system validation
  • Capture and detection reagents for diagnostic kit development
  • Antigen mimics for infectious disease detection tools

Biotechnology & Industrial Applications

  • Components for biosensors and peptide-based detection systems
  • Functional peptides for material science and nanotechnology
  • Surface-binding or self-assembly peptides
  • Peptides used in directed evolution workflows
  • Bioconjugation building blocks for industrial R&D

Accelerate Your Research with Precision-Synthesized Linear Peptides

Unlock reliable performance, superior purity, and scientific accuracy with our custom linear peptide synthesis service. Designed for enterprise R&D teams, academic laboratories, and pharmaceutical innovators, our platform delivers high-quality peptides that support confident decision-making in assay development, mechanism studies, biomarker validation, and early-stage drug discovery. Submit your peptide requirements and receive a customized quotation and technical consultation within 24 hours. Our scientific team is ready to support your project from concept to delivery.

FAQs