Scrambled Peptide Library - Creative Peptides

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

Peptide library is a powerful tool in biological research, which is used to screen a large number of peptides in order to find a few key bioactive peptides. Creative Peptides has years of experience in designing and synthesizing custom peptide libraries. We can provide high-quality scrambled peptide library design and construction services.

Introduction

The design of scrambled peptide library is based on the internal replacement of the original peptide amino acid sequence. It is the most volatile peptide library that can display all possible peptide substitution structures and is usually used as a negative control to confirm that a particular sequence is the key to protein function or activity. It is also a random screening tool for finding new targets.

Applications

Peptide sequence optimization: preliminary identification of peptides that may have specific functions or activities in a group of active sequences.
Objective protein screening.
Negative control: the resulting peptides are often used as negative controls to show that specific sequences rather than amino acid composition are critical to activity.
Targeted molecular probes for proteins, antibodies, genes, etc.

Services

With the support of our scientists' accumulated knowledge and experience in peptides, Creative Peptides not only provide high-quality peptide synthesis services, but also through a unique synthesis platform to synthesize scrambled peptide libraries to help simplify problems in peptide-related research and assist scientific research.

Advantage

Different lengths: peptides composed of up to 100 amino acids can be synthesized.
Different quantity specifications: mg, g, kg.
Purity of different HPLC: 80% 90% 95% 98% 99%.
Peptide synthesis test report: HPLC map, Mass map, COA report.
Sub-packaging: peptides can be repackaged according to customer requirements.
Quick delivery: the finished product can be delivered and used as soon as possible, reducing the intermediate links.
Delivery time: 2-3 weeks. The peptide library is freeze-dried directly in a 96-well plate and can be directly used in follow-up experiments.
Consultation: free design assistance from the experts with rich experience.

FAQs

1. What is a scrambled peptide library and how is it used in research?

A scrambled peptide library consists of peptides with randomized amino acid sequences. It is primarily used as a negative control to confirm the importance of a specific peptide sequence in protein function or activity and to discover new peptide targets.

2. How can a scrambled peptide library help in peptide sequence optimization?

Scrambled peptide libraries allow for the preliminary identification of peptides with specific biological functions or activities. This helps researchers narrow down potential candidates for further study and optimization.

3. What are the key applications of scrambled peptide libraries in research?

Scrambled peptide libraries are used for target protein screening, negative control experiments, identifying active peptide sequences, and finding molecular probes for proteins, antibodies, and genes. They are also essential for studying protein-protein interactions and peptide activity.

4. What is the benefit of using scrambled peptides as negative controls?

Scrambled peptides are valuable as negative controls because they demonstrate that the activity observed in a peptide sequence is due to the specific amino acid sequence and not simply the composition of amino acids. This helps validate the key sequence for biological activity.

5. What peptide lengths and specifications can be synthesized in a scrambled peptide library?

Creative Peptides can synthesize scrambled peptide libraries with peptides of various lengths, up to 100 amino acids. We offer flexible specifications ranging from milligram to kilogram quantities, with purity levels ranging from 80% to 99%.

References

Li, J., Zhang, Q., Pang, Z., Wang, Y., Liu, Q., Guo, L., & Jiang, X. (2012). Identification of peptide sequences that target to the brain using in vivo phage display. Amino acids, 42(6), 2373-2381.
Dong, N. P., Liang, Y. Z., Yi, L. Z., & Lu, H. M. (2013). Investigation of scrambled ions in tandem mass spectra, part 2. On the influence of the ions on peptide identification. Journal of The American Society for Mass Spectrometry, 24(6), 857-867.
Hou, L., Zhu, D., Liang, Y. U., Tian, X., Li, L., Wang, P., ... & Meng, X. (2018). Identification of a specific peptide binding to colon cancer cells from a phage-displayed peptide library. British journal of cancer, 118(1), 79-87.