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  5. Acetyl-(Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-MSH (3-11) amide

Acetyl-(Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-MSH (3-11) amide

Acetyl-(Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-MSH (3-11) amide is a constrained α-MSH fragment containing multiple substitutions that fine-tune aromatic interactions and backbone rigidity. The cysteine residues enable potential disulfide stabilization, while D-2-Nal introduces hydrophobic depth. Its acetylated N-terminus supports enhanced conformational control. Researchers employ it to probe melanocortin receptor selectivity.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Acetyl-(Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-MSH (3-11) amide(CAS 212370-59-7)

CAT No: M2723

CAS No:212370-59-7

Synonyms/Alias:212370-59-7;HS024;Long Name (Added to Synonym);DTXSID301034918;AKOS024456803;(4R,10S,13S,16R,19S,22S,25S,28R)-25-butyl-13,22-bis(3-carbamimidamidopropyl)-28-acetamido-19-(1H-imidazol-4-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(naphthalen-2-ylmethyl)-6,9,12,15,18,21,24,27-octaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosane-4-carboxamide;(4R,10S,13S,16R,19S,22S,25S,28R)-28-Acetamido-25-butyl-13,22-bis[3-(diaminomethylideneamino)propyl]-19-(1H-imidazol-5-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(naphthalen-2-ylmethyl)-6,9,12,15,18,21,24,27-octaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octazacyclononacosane-4-carboxamide;N-Acetyl-L-cysteinyl-L-norleucyl-L-arginyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinamide cyclic (1->9)disulfide;

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cGMP Peptide
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  • Drug master files (DMF) filing
M.F/Formula
C58H79N19O10S2
M.W/Mr.
1266.5
Sequence
One Letter Code:CXRHXRWGC
Three Letter Code:Ac-Cys(1)-Nle-Arg-His-D-2Nal-Arg-Trp-Gly-Cys(1)-NH2
InChI
InChI=1S/C58H79N19O10S2/c1-3-4-14-40-51(82)72-41(16-9-20-65-57(60)61)53(84)77-45(25-37-27-64-31-69-37)55(86)75-43(23-33-18-19-34-11-5-6-12-35(34)22-33)54(85)73-42(17-10-21-66-58(62)63)52(83)76-44(24-36-26-67-39-15-8-7-13-38(36)39)50(81)68-28-48(79)71-46(49(59)80)29-88-89-30-47(56(87)74-40)70-32(2)78/h5-8,11-13,15,18-19,22,26-27,31,40-47,67H,3-4,9-10,14,16-17,20-21,23-25,28-30H2,1-2H3,(H2,59,80)(H,64,69)(H,68,81)(H,70,78)(H,71,79)(H,72,82)(H,73,85)(H,74,87)(H,75,86)(H,76,83)(H,77,84)(H4,60,61,65)(H4,62,63,66)/t40-,41-,42-,43+,44-,45-,46-,47-/m0/s1
InChI Key
PUOCNCOPVAOMDE-LQXMKOPKSA-N

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